TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.375 | Formula: C24H26Cl2NO2+
H donors: 0 H acceptors: 0 LogP: 6.88 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: C[n+]1c(CCCOc2ccccc2Cl)cccc1CCCOc1ccccc1Cl
InChi: 1S/C24H26Cl2NO2/c1-27-19(11-7-17-28-23-15-4-2-13-21(23)25)9-6-10-20(27)12-8-18-29-24-16-5-3-14-22(24)26/h2-6,9-10,13-16H,7-8,11-12,17-18H2,1H3/q+1
InChiKey: YIXCZNDGIANWJE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	SWI:SNF matrix associated	0.0086	0.0591	0.0591
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3954	0.3954
Brugia malayi	Cell division protein kinase 2	0.0054	0.0271	0.0271
Trypanosoma cruzi	cdc2-related kinase 1	0.0421	0.3954	0.3934
Schistosoma mansoni	serine/threonine protein kinase	0.0421	0.3954	0.3954
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.0155	0.0155
Plasmodium falciparum	protein kinase 5	0.0421	0.3954	0.3954
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0271	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0155
Loa Loa (eye worm)	norepinephrine transporter	0.0043	0.0155	0.0155
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0054	0.0271	0.0271
Echinococcus multilocularis	dual specificity	0.0408	0.3821	0.3821
Loa Loa (eye worm)	hypothetical protein	0.1001	0.9784	0.9784
Leishmania major	hypothetical protein, conserved	0.0031	0.0033	0.0033
Schistosoma mansoni	fusion	0.0031	0.0033	0.0033
Echinococcus multilocularis	hypothetical protein	0.0033	0.0056	0.0056
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Entamoeba histolytica	protein kinase domain containing protein	0.0209	0.1825	0.2149
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0074	0.0464	0.0432
Schistosoma mansoni	sodium/chloride dependent transporter	0.0043	0.0155	0.0155
Brugia malayi	GSG2	0.0033	0.0056	0.0056
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0852	0.8289	0.8283
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Brugia malayi	hypothetical protein	0.0033	0.0056	0.0056
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0033	0.0056	0.0056
Echinococcus granulosus	cyclin dependent kinase 9	0.0209	0.1825	0.1825
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0031	0.0033	0.0033
Trichomonas vaginalis	CMGC family protein kinase	0.0408	0.3821	0.3731
Brugia malayi	YY1-associated factor 2	0.0031	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0114	0.0114
Brugia malayi	brahma associated protein 60 kDa	0.0086	0.0591	0.0591
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Schistosoma mansoni	serine/threonine protein kinase	0.0209	0.1825	0.1825
Schistosoma mansoni	hypothetical protein	0.0086	0.0591	0.0591
Trypanosoma cruzi	cdc2-related kinase 1	0.0421	0.3954	0.3934
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0074	0.0464	0.0432
Leishmania major	hypothetical protein, conserved	0.0031	0.0033	0.0033
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0408	0.3821	0.3731
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0086	0.0591	0.0591
Loa Loa (eye worm)	brahma associated protein	0.0086	0.0591	0.0591
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0408	0.3821	0.3821
Echinococcus multilocularis	cyclin dependent kinase 1	0.0421	0.3954	0.3954
Onchocerca volvulus		0.0086	0.0591	1
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	serine/threonine kinase, putative	0.0054	0.0271	0.013
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0086	0.0591	0.0591
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0033	0.0056	0.0056
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0408	0.3821	0.3801
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0464	0.0325
Leishmania major	hypothetical protein, conserved	0.0031	0.0033	0.0033
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0074	0.0464	0.0464
Echinococcus granulosus	mitogen activated protein kinase 15	0.0054	0.0271	0.0271
Chlamydia trachomatis	DNA topoisomerase I	0.0086	0.0591	0.5
Trypanosoma cruzi	cdc2-related kinase 3	0.0421	0.3954	0.3934
Echinococcus multilocularis	zinc finger protein Ran binding	0.0031	0.0033	0.0033
Entamoeba histolytica	cell division protein kinase 2, putative	0.0454	0.4285	0.5136
Trichomonas vaginalis	CMGC family protein kinase	0.0408	0.3821	0.3731
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0464	0.0325
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0271	0.013
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0054	0.0271	0.0239
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0045	0.0173	0.0173
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	tumor protein p63	0.0247	0.2207	0.2207
Onchocerca volvulus		0.0036	0.0088	0.0988
Echinococcus granulosus	mitogen activated protein kinase 3	0.0074	0.0464	0.0464
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0408	0.3821	0.3821
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	SWI:SNF matrix associated	0.0086	0.0591	0.0591
Echinococcus granulosus	dual specificity	0.0408	0.3821	0.3821
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0852	0.8289	0.8289
Entamoeba histolytica	cell division protein kinase 2, putative	0.0421	0.3954	0.4735
Plasmodium vivax	hypothetical protein, conserved	0.0086	0.0591	0.0329
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0074	0.0464	0.0464
Trichomonas vaginalis	CMGC family protein kinase	0.0421	0.3954	0.3866
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0852	0.8289	0.8289
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Leishmania major	serine/threonine kinase-like protein, putative	0.0054	0.0271	0.0271
Echinococcus granulosus	tumor protein p63	0.0247	0.2207	0.2207
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0054	0.0271	0.0239
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0054	0.0271	0.0271
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	cyclin dependent kinase 5	0.0421	0.3954	0.3954
Echinococcus multilocularis	SWI:SNF matrix associated	0.0086	0.0591	0.0591
Loa Loa (eye worm)	serotonin transporter b	0.0043	0.0155	0.0155
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0421	0.3954	0.3954
Echinococcus multilocularis	mitogen activated protein kinase	0.0074	0.0464	0.0464
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0464	0.0325
Echinococcus multilocularis	cyclin dependent kinase 1	0.0421	0.3954	0.3954
Trichomonas vaginalis	CMGC family protein kinase	0.0408	0.3821	0.3731
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0031	0.0033	0.0033
Schistosoma mansoni	serine/threonine protein kinase	0.0852	0.8289	0.8289
Brugia malayi	Protein kinase domain containing protein	0.0421	0.3954	0.3954
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Schistosoma mansoni	kinase	0.0209	0.1825	0.1825
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0074	0.0464	0.0464
Trichomonas vaginalis	CMGC family protein kinase	0.0408	0.3821	0.3731
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0271	0.013
Brugia malayi	MAP kinase sur-1	0.0074	0.0464	0.0464
Plasmodium falciparum	MO15-related protein kinase	0.0054	0.0271	0.0271
Echinococcus granulosus	dual specificity	0.0408	0.3821	0.3821
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0054	0.0271	0.0271
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus granulosus	cyclin dependent kinase 9	0.0242	0.2155	0.2155
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Schistosoma mansoni	sodium/chloride dependent transporter	0.0029	0.0014	0.0014
Plasmodium vivax	protein kinase Crk2	0.0421	0.3954	0.3786
Schistosoma mansoni	RNA binding protein	0.0031	0.0033	0.0033
Schistosoma mansoni	hypothetical protein	0.0086	0.0591	0.0591
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0086	0.0591	0.0591
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Loa Loa (eye worm)	hypothetical protein	0.0831	0.8073	0.8073
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0831	0.8073	0.8073
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0054	0.0271	0.0271
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	cyclin dependent kinase	0.0421	0.3954	0.3954
Leishmania major	hypothetical protein, conserved	0.0031	0.0033	0.0033
Echinococcus granulosus	dual specificity	0.0408	0.3821	0.3821
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0271	0.013
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0054	0.0271	0.0239
Echinococcus granulosus	zinc finger protein Ran binding	0.0031	0.0033	0.0033
Echinococcus granulosus	cyclin dependent kinase 5	0.0421	0.3954	0.3954
Schistosoma mansoni	serine/threonine protein kinase	0.0408	0.3821	0.3821
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0421	0.3954	0.3954
Schistosoma mansoni	cellular tumor antigen P53	0.0036	0.0088	0.0088
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0054	0.0271	0.0271
Loa Loa (eye worm)	haspin protein kinase	0.0054	0.0271	0.0271
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0408	0.3821	0.3801
Giardia lamblia	Kinase, CMGC CDK	0.0421	0.3954	0.3786
Brugia malayi	Protein kinase domain containing protein	0.0852	0.8289	0.8289
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0214	0.0214
Schistosoma mansoni	hypothetical protein	0.0031	0.0033	0.0033
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0086	0.0591	0.0329
Trypanosoma cruzi	cdc2-related kinase 3	0.0421	0.3954	0.3934
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0074	0.0464	0.0432
Echinococcus multilocularis	ring and YY1 binding protein	0.0031	0.0033	0.0033
Echinococcus multilocularis	serotonin transporter	0.0043	0.0155	0.0155
Echinococcus granulosus	SWI:SNF matrix associated	0.0086	0.0591	0.0591
Echinococcus multilocularis		0.1001	0.9784	0.9784
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0271	0.013
Entamoeba histolytica	protein kinase domain containing protein	0.0852	0.8289	1
Echinococcus multilocularis	dual specificity	0.0852	0.8289	0.8289
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Schistosoma mansoni	brg-1 associated factor	0.0086	0.0591	0.0591
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	dual specificity	0.0408	0.3821	0.3821
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0054	0.0271	0.0239
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	dual specificity	0.0408	0.3821	0.3821
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0033	0.0033
Echinococcus granulosus	serotonin transporter	0.0043	0.0155	0.0155
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0086	0.0591	0.0591
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0421	0.3954	0.3954
Echinococcus multilocularis	cyclin dependent kinase 9	0.0209	0.1825	0.1825
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0054	0.0271	0.0271
Brugia malayi	brahma associated protein 60 kDa	0.0086	0.0591	0.0591
Trichomonas vaginalis	CMGC family protein kinase	0.0421	0.3954	0.3866
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0155	0.0155
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0074	0.0464	0.0432
Loa Loa (eye worm)	haspin protein kinase	0.0033	0.0056	0.0056
Leishmania major	hypothetical protein, conserved	0.0031	0.0033	0.0033
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0209	0.1825	0.1825
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0408	0.3821	0.3821
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0033	0.0056	0.0056
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.0033	0.0056	0.0056
Giardia lamblia	Kinase, CMGC CDK	0.0421	0.3954	0.3786
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0464	0.0464
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.0271	0.013
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0031	0.0033	0.0033
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0852	0.8289	0.8283
Trypanosoma brucei	cdc2-related kinase 1	0.0421	0.3954	0.3934
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0271	0.013
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0214	0.0214
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0031	0.0033	0.0033
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Brugia malayi	cell division control protein 2 homolog	0.0421	0.3954	0.3954
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0408	0.3821	0.3821
Trichomonas vaginalis	conserved hypothetical protein	0.0086	0.0591	0.0454
Giardia lamblia	Kinase, CMGC MAPK	0.0074	0.0464	0.0198
Onchocerca volvulus		0.0043	0.0155	0.2181
Chlamydia trachomatis	SWIB complex protein	0.0086	0.0591	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0054	0.0271	0.0271
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus granulosus	mitogen activated protein kinase	0.0074	0.0464	0.0464
Brugia malayi	SWIB/MDM2 domain containing protein	0.0086	0.0591	0.0591
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0464	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0033	0.0033
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0033	0.0056	0.0056
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0031	0.0033	0.0033
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0086	0.0591	0.0591
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0054	0.0271	0.0271
Brugia malayi	cyclin-dependent kinase 9	0.0209	0.1825	0.1825
Loa Loa (eye worm)	hypothetical protein	0.0399	0.3739	0.3739
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0031	0.0033	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0271	0.0271
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0054	0.0271	0.013
Schistosoma mansoni	protein kinase	0.0054	0.0271	0.0271
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0852	0.8289	0.8283
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0074	0.0464	0.0464
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0173	0.0173
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0173	0.0173
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0054	0.0271	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0421	0.3954	0.3866
Loa Loa (eye worm)	haspin protein kinase	0.0033	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0155	0.0155
Treponema pallidum	sodium- and chloride- dependent transporter	0.0043	0.0155	0.5
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0074	0.0464	0.0432
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0031	0.0033	0.0033
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Entamoeba histolytica	protein kinase domain containing protein	0.0054	0.0271	0.0262
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0033	0.0033
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0074	0.0464	0.0464
Echinococcus granulosus	hypothetical protein	0.1001	0.9784	0.9784
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Echinococcus multilocularis	cyclin dependent kinase 9	0.0242	0.2155	0.2155
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0031	0.0033	0.0033
Schistosoma mansoni	TRABID protein (C64 family)	0.0031	0.0033	0.0033
Trypanosoma brucei	protein kinase, putative	0.0106	0.0795	0.0764
Echinococcus granulosus	Zinc finger RanBP2 type	0.0031	0.0033	0.0033
Schistosoma mansoni	serine/threonine kinase	0.0054	0.0271	0.0271
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0033	0.0056	0.0056
Echinococcus granulosus	dual specificity	0.0852	0.8289	0.8289
Entamoeba histolytica	protein kinase, putative	0.0408	0.3821	0.4574
Schistosoma mansoni	hypothetical protein	0.0033	0.0056	0.0056
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0421	0.3954	0.3954
Giardia lamblia	Kinase, CMGC DYRK	0.0408	0.3821	0.3649
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0408	0.3821	0.3731
Toxoplasma gondii	ran binding protein	0.0031	0.0033	0.0033
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Entamoeba histolytica	protein kinase, putative	0.0852	0.8289	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0421	0.3954	0.3954
Echinococcus granulosus	ring and YY1 binding protein	0.0031	0.0033	0.0033
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0031	0.0033	0.0033
Schistosoma mansoni	zinc finger protein	0.0031	0.0033	0.0033
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0043	0.0155	0.0155
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Entamoeba histolytica	hypothetical protein	0.0852	0.8289	1
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0271	0.013
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0421	0.3954	0.3954
Entamoeba histolytica	protein kinase domain containing protein	0.0408	0.3821	0.4574
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0088	0.0088
Echinococcus granulosus	cyclin dependent kinase 1	0.0421	0.3954	0.3954
Schistosoma mansoni	hypothetical protein	0.0033	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0086	0.0591	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0033	0.0033
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0421	0.3954	0.3954
Echinococcus granulosus	cyclin dependent kinase	0.0421	0.3954	0.3954
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0086	0.0591	0.0591
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0086	0.0591	0.0591
Entamoeba histolytica	protein kinase, putative	0.0852	0.8289	1
Trypanosoma brucei	cdc2-related kinase 3	0.0421	0.3954	0.3934

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 74 nM	Displacement of [3H]astemizole from human ERG K+ channel expressed in HEK293 cells by scintillation spectrophotometric analysis	ChEMBL.	23473309

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2324246

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1727203