Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0179 | 0.1742 | 0.1742 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0195 | 0.2163 | 0.0853 |
Echinococcus granulosus | dual specificity | 0.0363 | 0.6665 | 0.6665 |
Trypanosoma brucei | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0219 | 0.2814 | 0.1297 |
Echinococcus multilocularis | dual specificity | 0.0219 | 0.2814 | 0.2814 |
Echinococcus multilocularis | dual specificity | 0.0219 | 0.2814 | 0.2814 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0219 | 0.2814 | 0.2176 |
Entamoeba histolytica | protein kinase, putative | 0.0363 | 0.6665 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0219 | 0.2814 | 0.1297 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.9737 | 0.9692 |
Toxoplasma gondii | cell-cycle-associated protein kinase DYRK2, putative | 0.0219 | 0.2814 | 0.1297 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0219 | 0.2814 | 0.1297 |
Echinococcus granulosus | dual specificity | 0.0219 | 0.2814 | 0.2814 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0219 | 0.2814 | 0.1297 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0179 | 0.1742 | 0.1742 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0363 | 0.6665 | 1 |
Echinococcus granulosus | cyclin dependent kinase | 0.0179 | 0.1742 | 0.1742 |
Brugia malayi | Protein kinase domain containing protein | 0.0363 | 0.6665 | 0.5962 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK2 protein kinase | 0.0219 | 0.2814 | 0.1565 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.6403 | 0.5778 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.6403 | 0.5778 |
Entamoeba histolytica | hypothetical protein | 0.0363 | 0.6665 | 1 |
Brugia malayi | Dual-specificity tyrosine-phosphorylation regulated kinase 2 | 0.0219 | 0.2814 | 0.1297 |
Entamoeba histolytica | protein kinase, putative | 0.0363 | 0.6665 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0477 | 0.9737 | 0.9737 |
Echinococcus multilocularis | 0.0477 | 0.9737 | 0.9737 | |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0179 | 0.1742 | 0.1742 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0219 | 0.2814 | 0.1297 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0179 | 0.1742 | 0.0308 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0363 | 0.6665 | 0.5962 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0219 | 0.2814 | 0.1297 |
Echinococcus granulosus | dual specificity | 0.0219 | 0.2814 | 0.2814 |
Giardia lamblia | Kinase, CMGC DYRK | 0.0219 | 0.2814 | 0.1297 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0179 | 0.1742 | 0.1742 |
Echinococcus multilocularis | dual specificity | 0.0363 | 0.6665 | 0.6665 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0179 | 0.1742 | 0.1742 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0363 | 0.6665 | 0.6086 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0363 | 0.6665 | 0.5962 |
Trypanosoma cruzi | dual specificity tyrosine-phosphorylation-regulated kinase 2, putative | 0.0219 | 0.2814 | 0.1297 |
Leishmania major | protein kinase, putative,dual-specificity protein kinase, putative | 0.0219 | 0.2814 | 0.1297 |
Echinococcus multilocularis | dual specificity | 0.0219 | 0.2814 | 0.2814 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0179 | 0.1742 | 0.0308 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0219 | 0.2814 | 0.1297 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0363 | 0.6665 | 0.5962 |
Entamoeba histolytica | protein kinase, putative | 0.0219 | 0.2814 | 0.2176 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0363 | 0.6665 | 0.5962 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0179 | 0.1742 | 0.0308 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0179 | 0.1742 | 0.1742 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0219 | 0.2814 | 0.1297 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0179 | 0.1742 | 0.1742 |
Echinococcus granulosus | dual specificity | 0.0219 | 0.2814 | 0.2814 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0363 | 0.6665 | 0.5962 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.06 mM | Inhibition of human NF-kappaB p50/DNA interaction using 32P-labeled oligonucleotides as substrate preincubated for 20 mins before substrate addition measured after 20 mins by electrophoretic mobility shift assay | ChEMBL. | 23414143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.