TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.229 | Formula: C9H23NO7P2
H donors: 6 H acceptors: 7 LogP: -3.87 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCNCC(P(=O)(O)O)(P(=O)(O)O)O
InChi: 1S/C9H23NO7P2/c1-2-3-4-5-6-7-10-8-9(11,18(12,13)14)19(15,16)17/h10-11H,2-8H2,1H3,(H2,12,13,14)(H2,15,16,17)
InChiKey: LTKNPCBWFPJZHN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Toxoplasma gondii	polyprenyl synthetase superfamily protein	Starlite/ChEMBL	References
Trypanosoma cruzi	farnesyl pyrophosphate synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	farnesyl pyrophosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Echinococcus granulosus	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Plasmodium falciparum	geranylgeranyl pyrophosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Plasmodium berghei	geranylgeranyl pyrophosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Cryptosporidium hominis	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Theileria parva	farnesyl pyrophosphate synthetase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Babesia bovis	farnesyl pyrophosphate synthetase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Neospora caninum	hypothetical protein	Get druggable targets OG5_127590	All targets in OG5_127590
Plasmodium knowlesi	geranylgeranyl pyrophosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Candida albicans	similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase)	Get druggable targets OG5_127590	All targets in OG5_127590
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Leishmania mexicana	farnesyl pyrophosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Schistosoma mansoni	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Echinococcus multilocularis	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Brugia malayi	Polyprenyl synthetase family protein	Get druggable targets OG5_127590	All targets in OG5_127590
Candida albicans	similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase)	Get druggable targets OG5_127590	All targets in OG5_127590
Cryptosporidium parvum	putative farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Toxoplasma gondii	polyprenyl synthetase superfamily protein	Get druggable targets OG5_127590	All targets in OG5_127590
Leishmania braziliensis	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Trichomonas vaginalis	geranylgeranyl diphosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Trypanosoma brucei	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Giardia lamblia	Farnesyl diphosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Mycobacterium tuberculosis	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)	Get druggable targets OG5_127590	All targets in OG5_127590
Leishmania infantum	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Trypanosoma congolense	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Trypanosoma cruzi	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Plasmodium vivax	geranylgeranyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Plasmodium yoelii	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Loa Loa (eye worm)	polyprenyl synthetase	Get druggable targets OG5_127590	All targets in OG5_127590
Leishmania major	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590
Schistosoma japonicum	ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative	Get druggable targets OG5_127590	All targets in OG5_127590
Trypanosoma cruzi	farnesyl pyrophosphate synthase, putative	Get druggable targets OG5_127590	All targets in OG5_127590
Leishmania donovani	farnesyl pyrophosphate synthase	Get druggable targets OG5_127590	All targets in OG5_127590

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G-protein coupled receptor	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Giardia lamblia	Kinase, CMGC CDK	0.0602	0.4979	0.492
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Entamoeba histolytica	protein kinase, putative	0.1036	0.8985	1
Brugia malayi	putative neuropeptide receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.1121	0.9762	0.9762
Schistosoma mansoni	farnesyl pyrophosphate synthase	0.0248	0.1708	0.1708
Echinococcus granulosus	tm gpcr rhodopsin	0.0153	0.0833	0.0833
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0153	0.0833	0.0833
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Trichomonas vaginalis	CMGC family protein kinase	0.041	0.3208	0.3128
Echinococcus multilocularis	allatostatin A receptor	0.0153	0.0833	0.0833
Trichomonas vaginalis	CMGC family protein kinase	0.041	0.3208	0.3128
Brugia malayi	Serotonin receptor	0.0153	0.0833	0.0833
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0075	0.0117	0.0117
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0602	0.4979	0.4979
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0153	0.0833	0.5
Schistosoma mansoni	neuropeptide receptor	0.0153	0.0833	0.0833
Trypanosoma brucei	cdc2-related kinase 1	0.0602	0.4979	0.4979
Echinococcus multilocularis	serotonin receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0602	0.4979	0.4979
Leishmania major	farnesyl pyrophosphate synthase	0.0248	0.1708	0.1708
Brugia malayi	cyclin-dependent kinase 9	0.0307	0.2256	0.2256
Brugia malayi	MAP kinase sur-1	0.0076	0.0127	0.0127
Schistosoma mansoni	serine/threonine protein kinase	0.0076	0.0127	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Schistosoma mansoni	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	cyclin dependent kinase 1	0.0602	0.4979	0.4979
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	g protein coupled receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Schistosoma mansoni	serine/threonine protein kinase	0.1036	0.8985	0.8985
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.1036	0.8985	0.8985
Schistosoma mansoni	neuropeptide f receptor 76f	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Brugia malayi	neuropeptide F receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.041	0.3208	0.3208
Echinococcus multilocularis	neuropeptide Y receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	serine/threonine protein kinase	0.041	0.3208	0.3208
Loa Loa (eye worm)	neuropeptide F receptor	0.0153	0.0833	0.0833
Plasmodium falciparum	geranylgeranyl pyrophosphate synthase, putative	0.0248	0.1708	0.1708
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0153	0.0833	0.0833
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.1036	0.8985	0.8985
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0076	0.0127	0.0127
Echinococcus granulosus	mitogen activated protein kinase	0.0076	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	dual specificity	0.041	0.3208	0.3208
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Echinococcus granulosus	neuropeptide Y receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	mitogen activated protein kinase	0.0076	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0602	0.4979	0.4979
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0153	0.0833	0.0833
Trypanosoma cruzi	cdc2-related kinase 3	0.0602	0.4979	0.4979
Onchocerca volvulus		0.0153	0.0833	0.5
Schistosoma mansoni	biogenic amine receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	amine GPCR	0.0153	0.0833	0.0833
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.041	0.3208	0.3208
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0153	0.0833	0.0833
Schistosoma mansoni	protein kinase	0.0075	0.0117	0.0117
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.0248	0.1708	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0153	0.0833	0.0833
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0602	0.4979	0.4979
Onchocerca volvulus		0.0153	0.0833	0.5
Plasmodium vivax	cyclin dependent kinase 7 (cdk7), putative	0.0075	0.0117	0.0117
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Plasmodium vivax	serine/threonine protein kinase KIN, putative	0.0075	0.0117	0.0117
Schistosoma mansoni	serine/threonine kinase	0.0075	0.0117	0.0117
Mycobacterium tuberculosis	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)	0.0248	0.1708	1
Brugia malayi	Protein kinase domain containing protein	0.0075	0.0117	0.0117
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Echinococcus granulosus	dro:myosuppressin receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	serotonin receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Loa Loa (eye worm)	G-protein coupled receptor	0.0153	0.0833	0.0833
Trypanosoma brucei	farnesyl pyrophosphate synthase	0.0248	0.1708	0.1708
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0076	0.0127	0.0127
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0075	0.0117	0.0117
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0153	0.0833	0.0833
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Echinococcus multilocularis	cyclin dependent kinase	0.0602	0.4979	0.4979
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	G-protein coupled receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	sex peptide receptor	0.0153	0.0833	0.0833
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0076	0.0127	0.0127
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0076	0.0127	0.0127
Echinococcus granulosus	neuropeptide receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	amine GPCR	0.0153	0.0833	0.0833
Echinococcus multilocularis	g-protein coupled receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	g protein coupled receptor	0.0153	0.0833	0.0833
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.041	0.3208	0.3208
Entamoeba histolytica	protein kinase domain containing protein	0.0307	0.2256	0.251
Echinococcus multilocularis	neuropeptide receptor A26	0.0153	0.0833	0.0833
Echinococcus granulosus	g protein coupled receptor	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	G protein coupled receptor 139	0.0153	0.0833	0.0833
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Entamoeba histolytica	protein kinase, putative	0.1036	0.8985	1
Brugia malayi	Serotonin receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Trypanosoma cruzi	farnesyl pyrophosphate synthase	0.0248	0.1708	0.1708
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Brugia malayi	G protein-coupled receptor F59B2.13	0.0153	0.0833	0.0833
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Echinococcus multilocularis		0.1121	0.9762	0.9762
Echinococcus granulosus	cyclin dependent kinase 9	0.0307	0.2256	0.2256
Echinococcus multilocularis	neuropeptide receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	sex peptide receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0153	0.0833	0.0833
Schistosoma mansoni	amine GPCR	0.0153	0.0833	0.0833
Echinococcus multilocularis	G protein coupled receptor 139	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	mitogen activated protein kinase 3	0.0076	0.0127	0.0127
Schistosoma mansoni	biogenic amine receptor	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Brugia malayi	ORL1-like opioid receptor	0.0153	0.0833	0.0833
Brugia malayi	follicle stimulating hormone receptor	0.0153	0.0833	0.0833
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0076	0.0127	0.0127
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	neuropeptides capa receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	amine GPCR	0.0153	0.0833	0.0833
Echinococcus granulosus	neuropeptide s receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	biogenic amine 5HT receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	cyclin dependent kinase 5	0.0602	0.4979	0.4979
Schistosoma mansoni	neuropeptide F-like receptor	0.0153	0.0833	0.0833
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.1036	0.8985	0.8985
Loa Loa (eye worm)	haspin protein kinase	0.0075	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	dual specificity	0.1036	0.8985	0.8985
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0576	0.4741	0.4741
Schistosoma mansoni	opsin-like receptor	0.0153	0.0833	0.0833
Brugia malayi	Melatonin receptor type 1A	0.0153	0.0833	0.0833
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0602	0.4979	0.4979
Schistosoma mansoni	growth hormone secretagogue receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	g protein coupled receptor	0.0153	0.0833	0.0833
Entamoeba histolytica	hypothetical protein	0.1036	0.8985	1
Echinococcus granulosus	dual specificity	0.041	0.3208	0.3208
Brugia malayi	Dopamine receptor protein 1	0.0153	0.0833	0.0833
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0153	0.0833	0.0833
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0153	0.0833	0.0833
Brugia malayi	G protein-coupled receptor	0.0153	0.0833	0.0833
Trichomonas vaginalis	CMGC family protein kinase	0.041	0.3208	0.3128
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0153	0.0833	0.0833
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0075	0.0117	0.0117
Brugia malayi	Cell division protein kinase 2	0.0075	0.0117	0.0117
Schistosoma mansoni	serine/threonine protein kinase	0.0602	0.4979	0.4979
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0076	0.0127	0.0127
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Schistosoma mansoni	opsin-like receptor	0.0153	0.0833	0.0833
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.0248	0.1708	1
Trichomonas vaginalis	CMGC family protein kinase	0.0076	0.0127	0.001
Trypanosoma cruzi	cdc2-related kinase 1	0.0602	0.4979	0.4979
Brugia malayi	neuropeptide F receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	amine GPCR	0.0153	0.0833	0.0833
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0602	0.4979	0.4979
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Brugia malayi	Protein kinase domain containing protein	0.1036	0.8985	0.8985
Echinococcus granulosus	somatostatin receptor	0.0153	0.0833	0.0833
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0248	0.1708	0.1708
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.041	0.3208	0.3208
Schistosoma mansoni	serine/threonine protein kinase	0.0602	0.4979	0.4979
Onchocerca volvulus		0.0153	0.0833	0.5
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	cyclin dependent kinase 5	0.0602	0.4979	0.4979
Echinococcus granulosus	fmrfamide receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	neuropeptide Y receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Loa Loa (eye worm)	TYRA-2 protein	0.0153	0.0833	0.0833
Trypanosoma brucei	cdc2-related kinase 3	0.0602	0.4979	0.4979
Echinococcus multilocularis	neuropeptide s receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	hypothetical protein	0.1121	0.9762	0.9762
Schistosoma mansoni	neuropeptide receptor	0.0153	0.0833	0.0833
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	dual specificity	0.041	0.3208	0.3208
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0153	0.0833	0.0833
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0153	0.0833	0.0833
Brugia malayi	cell division control protein 2 homolog	0.0602	0.4979	0.4979
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0075	0.0117	0.0117
Onchocerca volvulus		0.0153	0.0833	0.5
Giardia lamblia	Kinase, CMGC CDK	0.0602	0.4979	0.492
Echinococcus granulosus	cyclin dependent kinase	0.0602	0.4979	0.4979
Schistosoma mansoni	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0153	0.0833	0.0833
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0153	0.0833	0.0833
Echinococcus multilocularis	cyclin dependent kinase 9	0.0307	0.2256	0.2256
Brugia malayi	Dopamine receptor protein 2	0.0153	0.0833	0.0833
Echinococcus granulosus	allatostatin A receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0153	0.0833	0.0833
Echinococcus multilocularis	farnesyl pyrophosphate synthase	0.0248	0.1708	0.1708
Brugia malayi	G-protein coupled receptor	0.0153	0.0833	0.0833
Brugia malayi	hypothetical protein	0.0153	0.0833	0.0833
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.041	0.3208	0.3208
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0153	0.0833	0.5
Schistosoma mansoni	opsin-like receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	7TM GPCR rhodopsin	0.0153	0.0833	0.0833
Trichomonas vaginalis	CMGC family protein kinase	0.0076	0.0127	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0307	0.2256	0.2256
Trypanosoma brucei	protein kinase, putative	0.0126	0.0582	0.0582
Echinococcus granulosus	orexin receptor type 2	0.0153	0.0833	0.0833
Echinococcus granulosus	biogenic amine 5HT receptor	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0153	0.0833	0.0833
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0153	0.0833	0.0833
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0153	0.0833	0.0833
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0076	0.0127	0.0127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.1036	0.8985	0.8985
Plasmodium falciparum	MO15-related protein kinase	0.0075	0.0117	0.0117
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0075	0.0117	0.0117
Onchocerca volvulus		0.0153	0.0833	0.5
Plasmodium vivax	protein kinase Crk2	0.0602	0.4979	0.4979
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.0248	0.1708	0.1611
Trichomonas vaginalis	CMGC family protein kinase	0.041	0.3208	0.3128
Brugia malayi	AKH receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0075	0.0117	0.0117
Echinococcus multilocularis	serotonin receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Giardia lamblia	Kinase, CMGC MAPK	0.0076	0.0127	0.001
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0307	0.2256	0.2256
Echinococcus multilocularis	g protein coupled receptor	0.0153	0.0833	0.0833
Plasmodium vivax	geranylgeranyl pyrophosphate synthase	0.0248	0.1708	0.1708
Entamoeba histolytica	protein kinase domain containing protein	0.041	0.3208	0.357
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	melatonin receptor type 1A	0.0153	0.0833	0.0833
Entamoeba histolytica	cell division protein kinase 2, putative	0.0602	0.4979	0.5542
Schistosoma mansoni	neuropeptide receptor	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Schistosoma mansoni	adenoreceptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0075	0.0117	0.0117
Trichomonas vaginalis	CMGC family protein kinase	0.041	0.3208	0.3128
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	neuropeptides capa receptor	0.0153	0.0833	0.0833
Entamoeba histolytica	cell division protein kinase 2, putative	0.0652	0.5434	0.6048
Giardia lamblia	Kinase, CMGC DYRK	0.041	0.3208	0.3128
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Echinococcus multilocularis	neuropeptide receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	neuropeptide FF receptor 2	0.0153	0.0833	0.0833
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.0833	0.0833
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Echinococcus granulosus	cyclin dependent kinase 9	0.0356	0.271	0.271
Schistosoma mansoni	biogenic amine receptor	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	dual specificity	0.041	0.3208	0.3208
Schistosoma mansoni	myosin xvIII	0.0153	0.0833	0.0833
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0153	0.0833	0.0833
Echinococcus granulosus	farnesyl pyrophosphate synthase	0.0248	0.1708	0.1708
Trichomonas vaginalis	CMGC family protein kinase	0.0602	0.4979	0.492
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0153	0.0833	0.0833
Echinococcus multilocularis	dro:myosuppressin receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	cyclin dependent kinase 9	0.0356	0.271	0.271
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0076	0.0127	0.0127
Onchocerca volvulus		0.0153	0.0833	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0153	0.0833	0.0833
Echinococcus granulosus	dual specificity	0.1036	0.8985	0.8985
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0075	0.0117	0.0117
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	dual specificity	0.041	0.3208	0.3208
Echinococcus granulosus	neuropeptides capa receptor	0.0153	0.0833	0.0833
Trypanosoma cruzi	farnesyl pyrophosphate synthase, putative	0.0248	0.1708	0.1708
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0153	0.0833	0.0833
Loa Loa (eye worm)	neuropeptide F receptor	0.0153	0.0833	0.0833
Leishmania major	serine/threonine kinase-like protein, putative	0.0075	0.0117	0.0117
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0153	0.0833	0.0833
Echinococcus granulosus	cyclin dependent kinase 1	0.0602	0.4979	0.4979
Giardia lamblia	Farnesyl diphosphate synthase	0.0248	0.1708	0.1611
Trichomonas vaginalis	CMGC family protein kinase	0.0602	0.4979	0.492
Schistosoma mansoni	serine/threonine protein kinase	0.0075	0.0117	0.0117
Entamoeba histolytica	protein kinase domain containing protein	0.1036	0.8985	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	fmrfamide receptor	0.0153	0.0833	0.0833
Trichomonas vaginalis	CMGC family protein kinase	0.0076	0.0127	0.001
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.1036	0.8985	0.8985
Echinococcus multilocularis	cyclin dependent kinase 1	0.0602	0.4979	0.4979
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0153	0.0833	0.0833
Schistosoma mansoni	histamine h1 receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	orexin receptor type 2	0.0153	0.0833	0.0833
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0153	0.0833	0.0833
Trypanosoma cruzi	cdc2-related kinase 3	0.0602	0.4979	0.4979
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0153	0.0833	0.0833
Brugia malayi	Protein kinase domain containing protein	0.0602	0.4979	0.4979
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.0248	0.1708	0.1611
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0075	0.0117	0.0117
Trypanosoma cruzi	cdc2-related kinase 1	0.0602	0.4979	0.4979
Entamoeba histolytica	protein kinase, putative	0.041	0.3208	0.357
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0076	0.0127	0.0127
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0075	0.0117	0.0117
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Brugia malayi	GnHR receptor homolog	0.0153	0.0833	0.0833
Echinococcus granulosus	tm gpcr rhodopsin	0.0153	0.0833	0.0833
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0153	0.0833	0.0833
Echinococcus multilocularis	fmrfamide receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	neuropeptide receptor A26	0.0153	0.0833	0.0833
Schistosoma mansoni	kinase	0.0307	0.2256	0.2256
Brugia malayi	putative neuropeptide receptor NPR1	0.0153	0.0833	0.0833
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0153	0.0833	0.0833
Brugia malayi	Dopamine receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0075	0.0117	0.0117
Echinococcus granulosus	neuropeptides capa receptor	0.0153	0.0833	0.0833
Brugia malayi	RE15519p	0.0153	0.0833	0.0833
Brugia malayi	Polyprenyl synthetase family protein	0.0248	0.1708	0.1708
Plasmodium falciparum	protein kinase 5	0.0602	0.4979	0.4979
Echinococcus granulosus	neuropeptide receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.041	0.3208	0.3128
Trichomonas vaginalis	geranylgeranyl diphosphate synthase, putative	0.0248	0.1708	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0153	0.0833	0.0833
Echinococcus granulosus	dual specificity	0.041	0.3208	0.3208
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0153	0.0833	0.0833
Echinococcus multilocularis	somatostatin receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Onchocerca volvulus		0.0153	0.0833	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0153	0.0833	0.0833
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.041	0.3208	0.3208
Brugia malayi	sulfakinin receptor protein	0.0153	0.0833	0.0833
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0153	0.0833	0.0833
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0075	0.0117	0.0117
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0602	0.4979	0.4979
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Schistosoma mansoni	neuropeptide receptor	0.0153	0.0833	0.0833
Echinococcus multilocularis	neuropeptide Y receptor	0.0153	0.0833	0.0833
Trichomonas vaginalis	CMGC family protein kinase	0.0602	0.4979	0.492
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.0833	0.0833
Echinococcus multilocularis	g protein coupled receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.1011	0.8747	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.1011	0.8747	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Brugia malayi	larval opioid receptor	0.0153	0.0833	0.0833
Loa Loa (eye worm)	polyprenyl synthetase	0.0248	0.1708	0.1708
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0833	0.0833
Echinococcus granulosus	mitogen activated protein kinase 15	0.0075	0.0117	0.0117
Trichomonas vaginalis	CMGC family protein kinase	0.0076	0.0127	0.001
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0076	0.0127	0.0127
Entamoeba histolytica	protein kinase domain containing protein	0.0075	0.0117	0.013

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	>= 10 uM	Antimicrobial activity against Toxoplasma gondii tachyzoites expressing red fluorescence protein infected in hTerT cells measured daily by fluorescence assay	ChEMBL.	24300918
ED50 (functional)	> 10 uM	Antiparasitic activity against Toxoplasma gondii tachyzoite expressing red fluorescence protein assessed as growth inhibition by fluorescence plate reader	ChEMBL.	23318904
ED50 (functional)	> 20 uM	Antimicrobial activity against Trypanosoma cruzi CL amastigotes infected in african green monkey Vero cells measured on day 3 by fluorescence assay	ChEMBL.	24300918
ED50 (functional)	> 20 uM	Antiparasitic activity against Trypanosoma cruzi amastigotes infected in gamma-irradiated vero cells assessed as growth inhibition measured after 3 days by fluorescence assay	ChEMBL.	23318904
IC50 (binding)	> 1 uM	Inhibition of Toxoplasma gondii farnesyl diphosphate synthase assessed as incorporation of [4-14C]IPP measured at 37 degC	ChEMBL.	23318904
IC50 (binding)	> 1 uM	Inhibition of Toxoplasma gondii FPPS	ChEMBL.	24300918
IC50 (binding)	> 10 uM	Inhibition of Trypanosoma cruzi farnesyl diphosphate synthase assessed as incorporation of [4-14C]IPP measured at 37 degC	ChEMBL.	23318904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2326224

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1727213