Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Thrombin | Starlite/ChEMBL | References |
Bos taurus | Trypsin II | Starlite/ChEMBL | References |
Bos taurus | Coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Trypsin II | 247 aa | 205 aa | 30.2 % |
Drosophila melanogaster | CG9673 gene product from transcript CG9673-RB | Trypsin II | 247 aa | 258 aa | 26.4 % |
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Trypsin II | 247 aa | 262 aa | 31.3 % |
Drosophila melanogaster | CG4815 gene product from transcript CG4815-RA | Trypsin II | 247 aa | 208 aa | 27.4 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Trypsin II | 247 aa | 223 aa | 33.2 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin II | 247 aa | 217 aa | 23.0 % |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Trypsin II | 247 aa | 251 aa | 27.1 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Trypsin II | 247 aa | 298 aa | 24.5 % |
Echinococcus granulosus | Mastin | Trypsin II | 247 aa | 306 aa | 25.2 % |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Trypsin II | 247 aa | 203 aa | 20.7 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Trypsin II | 247 aa | 248 aa | 28.6 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Trypsin II | 247 aa | 250 aa | 31.6 % |
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Trypsin II | 247 aa | 249 aa | 23.7 % |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Trypsin II | 247 aa | 263 aa | 32.7 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Trypsin II | 247 aa | 301 aa | 22.3 % |
Drosophila melanogaster | CG3916 gene product from transcript CG3916-RA | Trypsin II | 247 aa | 257 aa | 33.5 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin II | 247 aa | 239 aa | 22.2 % |
Drosophila melanogaster | Jonah 66Ci | Trypsin II | 247 aa | 237 aa | 30.4 % |
Drosophila melanogaster | CG32277 gene product from transcript CG32277-RA | Trypsin II | 247 aa | 240 aa | 32.9 % |
Drosophila melanogaster | CG10405 gene product from transcript CG10405-RB | Trypsin II | 247 aa | 254 aa | 33.1 % |
Schistosoma japonicum | Enteropeptidase, putative | Trypsin II | 247 aa | 267 aa | 26.2 % |
Drosophila melanogaster | CG30323 gene product from transcript CG30323-RB | Trypsin II | 247 aa | 212 aa | 23.6 % |
Echinococcus granulosus | transmembrane protease serine 3 | Trypsin II | 247 aa | 233 aa | 34.3 % |
Drosophila melanogaster | Jonah 99Ci | Trypsin II | 247 aa | 268 aa | 32.5 % |
Schistosoma japonicum | Transmembrane protease, serine 9, putative | Trypsin II | 247 aa | 246 aa | 24.8 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Trypsin II | 247 aa | 302 aa | 23.2 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin II | 247 aa | 302 aa | 25.5 % |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Trypsin II | 247 aa | 224 aa | 29.5 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Trypsin II | 247 aa | 255 aa | 29.4 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Trypsin II | 247 aa | 244 aa | 37.3 % |
Drosophila melanogaster | Jonah 65Aii | Trypsin II | 247 aa | 237 aa | 35.4 % |
Drosophila melanogaster | Jonah 65Aiii | Trypsin II | 247 aa | 238 aa | 32.8 % |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Trypsin II | 247 aa | 303 aa | 24.8 % |
Onchocerca volvulus | Trypsin II | 247 aa | 257 aa | 26.5 % | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin II | 247 aa | 247 aa | 34.0 % |
Drosophila melanogaster | CG17239 gene product from transcript CG17239-RB | Trypsin II | 247 aa | 224 aa | 34.4 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin II | 247 aa | 217 aa | 23.0 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Trypsin II | 247 aa | 269 aa | 27.5 % |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Trypsin II | 247 aa | 236 aa | 30.1 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Trypsin II | 247 aa | 233 aa | 34.8 % |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Trypsin II | 247 aa | 233 aa | 28.3 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Trypsin II | 247 aa | 213 aa | 24.9 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Trypsin II | 247 aa | 287 aa | 27.2 % |
Drosophila melanogaster | CG18180 gene product from transcript CG18180-RA | Trypsin II | 247 aa | 234 aa | 31.2 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Trypsin II | 247 aa | 242 aa | 29.8 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Trypsin II | 247 aa | 257 aa | 28.8 % |
Echinococcus granulosus | enteropeptidase | Trypsin II | 247 aa | 227 aa | 26.4 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Trypsin II | 247 aa | 238 aa | 30.2 % |
Echinococcus multilocularis | Mastin | Trypsin II | 247 aa | 306 aa | 25.5 % |
Echinococcus multilocularis | enteropeptidase | Trypsin II | 247 aa | 227 aa | 26.0 % |
Onchocerca volvulus | Trypsin II | 247 aa | 258 aa | 22.9 % | |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Trypsin II | 247 aa | 287 aa | 27.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0336 | 0.3214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.3214 | 0.3214 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0336 | 0.3214 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0336 | 0.3214 | 0.3214 |
Loa Loa (eye worm) | brahma associated protein | 0.0945 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0945 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0945 | 1 | 1 |
Onchocerca volvulus | 0.0945 | 1 | 1 | |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0336 | 0.3214 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.3214 | 0.3214 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0945 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0945 | 1 | 1 |
Schistosoma mansoni | fusion | 0.0336 | 0.3214 | 0.3214 |
Onchocerca volvulus | 0.0106 | 0.0652 | 0.0652 | |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0336 | 0.3214 | 0.3214 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0945 | 1 | 1 |
Onchocerca volvulus | 0.0336 | 0.3214 | 0.3214 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0336 | 0.3214 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0945 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.3214 | 0.3214 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.3214 | 0.3214 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0336 | 0.3214 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0945 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0945 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0945 | 1 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0336 | 0.3214 | 0.3214 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0336 | 0.3214 | 0.3214 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0336 | 0.3214 | 0.3214 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0945 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.3214 | 0.3214 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0336 | 0.3214 | 0.5 |
Toxoplasma gondii | ran binding protein | 0.0336 | 0.3214 | 0.3214 |
Onchocerca volvulus | 0.0336 | 0.3214 | 0.3214 | |
Onchocerca volvulus | 0.0336 | 0.3214 | 0.3214 | |
Echinococcus granulosus | ring and YY1 binding protein | 0.0336 | 0.3214 | 0.3214 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0336 | 0.3214 | 0.3214 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0336 | 0.3214 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0842 | 0.0842 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0842 | 0.0842 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0945 | 1 | 1 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0336 | 0.3214 | 0.3214 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0945 | 1 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0945 | 1 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0945 | 1 | 1 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0336 | 0.3214 | 0.3214 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0336 | 0.3214 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0336 | 0.3214 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0336 | 0.3214 | 0.3214 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0336 | 0.3214 | 0.3214 |
Onchocerca volvulus | 0.0123 | 0.0842 | 0.0842 | |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0336 | 0.3214 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0336 | 0.3214 | 0.3214 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0842 | 0.0842 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0336 | 0.3214 | 0.3214 |
Schistosoma mansoni | hypothetical protein | 0.0945 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0336 | 0.3214 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0336 | 0.3214 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0336 | 0.3214 | 1 |
Schistosoma mansoni | RNA binding protein | 0.0336 | 0.3214 | 0.3214 |
Brugia malayi | Trypsin family protein | 0.0123 | 0.0842 | 0.0842 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0336 | 0.3214 | 0.3214 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0336 | 0.3214 | 0.3214 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0336 | 0.3214 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0945 | 1 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0336 | 0.3214 | 0.5 |
Plasmodium falciparum | zinc finger Ran-binding domain-containing protein 2, putative | 0.0336 | 0.3214 | 0.3214 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0842 | 0.0842 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0945 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0336 | 0.3214 | 0.3214 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0336 | 0.3214 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0336 | 0.3214 | 0.3214 |
Chlamydia trachomatis | SWIB complex protein | 0.0945 | 1 | 0.5 |
Onchocerca volvulus | 0.0336 | 0.3214 | 0.3214 | |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0945 | 1 | 1 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0336 | 0.3214 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0336 | 0.3214 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0945 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0945 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0336 | 0.3214 | 1 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0336 | 0.3214 | 0.3214 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0945 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.18 uM | Inhibitory activity against trypsin | ChEMBL. | 9301673 |
Ki (binding) | = 0.18 uM | Inhibitory activity against trypsin | ChEMBL. | 9301673 |
Ki (binding) | = 0.35 uM | Inhibitory activity against thrombin | ChEMBL. | 9301673 |
Ki (binding) | = 0.35 uM | Inhibitory activity against thrombin | ChEMBL. | 9301673 |
Ki (binding) | = 11 uM | Inhibitory activity against plasmin | ChEMBL. | 9301673 |
Ki (binding) | = 11 uM | Inhibitory activity against plasmin | ChEMBL. | 9301673 |
Ki (binding) | = 18 uM | Inhibitory activity against coagulation factor X. | ChEMBL. | 9301673 |
Ki (binding) | = 18 uM | Inhibitory activity against coagulation factor X. | ChEMBL. | 9301673 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.