Detailed information for compound 173080

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.268 | Formula: C20H26Br2N6O
  • H donors: 2 H acceptors: 0 LogP: 5.23 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCNC(=N)N/N=C/c1ccc(cc1)OCc1cn2c([n+]1C)ccc(c2)C.[Br-].Br
  • InChi: 1S/C20H25N6O.2BrH/c1-4-22-20(21)24-23-11-16-6-8-18(9-7-16)27-14-17-13-26-12-15(2)5-10-19(26)25(17)3;;/h5-13H,4,14H2,1-3H3,(H3,21,22,24);2*1H/q+1;;/p-1/b23-11+;;
  • InChiKey: QCTADOIKAXQXKP-JAVJUDMBSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0125 0.0125
Trichomonas vaginalis hypothetical protein 0.0114 0.1059 0.102
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0142 0.1078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0125 0.0125
Echinococcus multilocularis Protein lozenge 0.0061 0.0495 0.0495
Brugia malayi jmjC domain containing protein 0.0065 0.0533 0.0518
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Schistosoma mansoni coup transcription factor 0.0026 0.0125 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Leishmania major cathepsin L-like protease 0.0018 0.0043 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Brugia malayi hypoxia-induced factor 1 0.0165 0.1601 0.1587
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0031 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0125 0.0109
Giardia lamblia Translation elongation factor 0.0114 0.1059 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0125 0.0125
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0125 0.0125
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0125 0.0109
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0031 0.0031
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0125
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0017 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0032 0.0016
Onchocerca volvulus 0.003 0.0162 0.0294
Echinococcus multilocularis geminin 0.0186 0.1821 0.1821
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0157 0.0157
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0028
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.1601 0.1601
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0958 1 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0114 0.1059 0.1031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0125
Plasmodium vivax translation initiation factor 4E, putative 0.0114 0.1059 1
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0125 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0125 0.0109
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.0225
Leishmania major eukaryotic translation initiation factor, putative 0.0114 0.1059 0.1031
Echinococcus granulosus neuropeptide receptor A26 0.0508 0.523 0.523
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0114 0.1059 0.102
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0958 1 1
Schistosoma mansoni survival motor neuron protein 0.0053 0.041 0.0395
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0016 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0043 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0429 0.0413
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.0225
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.041 0.0395
Plasmodium vivax vivapain-2 0.0018 0.0043 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0591 0.0562
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0043 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0125 0.0109
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0533 0.0533
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1059 0.102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0125 0.0125
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0043 0.0043
Loa Loa (eye worm) runx1 0.0061 0.0495 0.0495
Loa Loa (eye worm) translation initiation factor 4E 0.0958 1 1
Leishmania major hypothetical protein, conserved 0.0028 0.0142 0.0111
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0043 0.0012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0125 0.0109
Echinococcus granulosus GPCR family 2 0.0017 0.0032 0.0032
Brugia malayi nuclear hormone receptor 0.0026 0.0125 0.0109
Echinococcus granulosus lamin 0.003 0.0162 0.0162
Mycobacterium ulcerans putative regulatory protein 0.004 0.0268 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0125 0.0109
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0043 0.0028
Onchocerca volvulus 0.0018 0.0043 0.0055
Brugia malayi jmjC domain containing protein 0.0017 0.0031 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0125 0.0125
Echinococcus multilocularis lamin 0.003 0.0162 0.0162
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0031 0.0015
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0016
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0114 0.1059 0.1031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0267 0.0267
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0591 0.0562
Echinococcus multilocularis lysine specific demethylase 5A 0.0065 0.0533 0.0533
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0125 0.0125
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0043 0.012
Echinococcus granulosus intermediate filament protein 0.003 0.0162 0.0162
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0162 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0125 0.0125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0028
Toxoplasma gondii hypothetical protein 0.0114 0.1059 0.1031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0381 0.0381
Brugia malayi jmjC domain containing protein 0.0017 0.0031 0.0015
Leishmania major protein kinase, putative 0.0018 0.0041 0.001
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0958 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0125
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0125 0.0125
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0198 0.1949 0.3877
Loa Loa (eye worm) intermediate filament protein 0.003 0.0162 0.0162
Onchocerca volvulus 0.0018 0.0043 0.0055
Brugia malayi Death domain containing protein 0.0016 0.0016 0.0000000097163
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0125 0.0125
Echinococcus granulosus neuropeptide s receptor 0.0508 0.523 0.523
Brugia malayi ecdysteroid receptor 0.0026 0.0125 0.0109
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0114 0.1059 0.1031
Brugia malayi N-terminal motif family protein 0.0198 0.1949 0.1937
Entamoeba histolytica hypothetical protein 0.0114 0.1059 0.102
Brugia malayi hypothetical protein 0.026 0.26 0.2589
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0125 0.0125
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0706 0.0706
Leishmania major cathepsin L-like protease 0.0018 0.0043 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0031 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0125 0.0125
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0125 0.0125
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0125 0.0125
Brugia malayi Cytochrome P450 family protein 0.0025 0.0112 0.0096
Brugia malayi steroid hormone receptor 0.0026 0.0125 0.0109
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0114 0.1059 0.1031
Entamoeba histolytica hypothetical protein 0.0114 0.1059 0.102
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0031 0.0015
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0958 1 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0031 0.0031
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0114 0.1059 0.102
Echinococcus multilocularis lamin dm0 0.003 0.0162 0.0162
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0114 0.1059 0.102
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0125 0.0109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0017
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0114 0.1059 0.1059
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0031 0.0031
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0958 1 1
Schistosoma mansoni single-minded 0.0053 0.0415 0.0399
Onchocerca volvulus 0.0018 0.0043 0.0055
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0125 0.0219
Onchocerca volvulus 0.0018 0.0043 0.0055
Plasmodium vivax vivapain-2 0.0018 0.0043 0.012
Schistosoma mansoni hypothetical protein 0.0037 0.0245 0.023
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0415 0.0399
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0043 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0114 0.1059 1
Onchocerca volvulus 0.003 0.0162 0.0294
Brugia malayi hypothetical protein 0.0028 0.0142 0.0126
Echinococcus granulosus single minded 2 0.004 0.0268 0.0268
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0268 0.0268
Giardia lamblia hypothetical protein 0.0114 0.1059 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0125 0.0125
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0381 0.0366
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0706 0.0706
Onchocerca volvulus 0.004 0.0268 0.0505
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0031 0.0015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0125 0.0219
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.004 0.0267 0.0252
Entamoeba histolytica translation initiation factor 4e, putative 0.0114 0.1059 0.102
Brugia malayi jmjC domain containing protein 0.0017 0.0031 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0162 0.0147
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0267 0.0252
Giardia lamblia Hypothetical protein 0.0114 0.1059 0.5
Loa Loa (eye worm) hypothetical protein 0.0198 0.1949 0.1949
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0125 0.0109
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0016 0.0000000097163
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0591 0.0562
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0179 0.1748 0.1748
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0527 0.0497
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0043 0.0043
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0958 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0125 0.0219
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0125
Echinococcus granulosus death domain containing protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0031
Onchocerca volvulus 0.0026 0.0125 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1059 0.102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0125 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0125 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0125 0.0109
Loa Loa (eye worm) hypothetical protein 0.0017 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0125 0.0125
Brugia malayi Uncoordinated protein 44 0.0016 0.0016 0.0000000097163
Loa Loa (eye worm) hypothetical protein 0.026 0.26 0.26
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0381 0.0366
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0142 0.1078
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0533 0.0518
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0114 0.1059 0.1031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0381 0.0366
Loa Loa (eye worm) hypothetical protein 0.0487 0.5003 0.5003
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0142 0.0111
Echinococcus granulosus microtubule associated protein 2 0.0758 0.7879 0.7879
Echinococcus granulosus phd:f box containing protein 0.0017 0.0031 0.0031
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 1
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0114 0.1059 0.1031
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0114 0.1059 0.1031
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0031 0.0031
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0125 0.0109
Brugia malayi bHLH-PAS transcription factor 0.004 0.0268 0.0252
Leishmania major cathepsin L-like protease 0.0018 0.0043 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0245
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0958 1 1
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0381 0.0381
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0958 1 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0016 0.0000000097163
Loa Loa (eye worm) hypothetical protein 0.0055 0.0429 0.0429
Echinococcus multilocularis cysteine protease 0.0018 0.0043 0.0043
Echinococcus granulosus Ankyrin 0.0016 0.0017 0.0017
Brugia malayi jmjC domain containing protein 0.0017 0.0031 0.0015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0125 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0125 0.0125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0381 0.0381
Echinococcus granulosus lamin dm0 0.003 0.0162 0.0162
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0958 1 1
Echinococcus granulosus geminin 0.0186 0.1821 0.1821
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0381 0.0366
Loa Loa (eye worm) hypothetical protein 0.0017 0.0032 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.0186 0.1821 0.1808
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0016
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0016 0.0016
Echinococcus granulosus cathepsin l1 0.0018 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0125 0.0109
Toxoplasma gondii cathepsin CPL 0.0018 0.0043 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0125 0.0109
Brugia malayi PAS domain containing protein 0.0053 0.0415 0.0399
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0125 0.0109
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0533 0.0518
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0043 0.0043
Onchocerca volvulus 0.0487 0.5003 1
Brugia malayi hypothetical protein 0.0487 0.5003 0.4995
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0958 1 1
Schistosoma mansoni hypothetical protein 0.0053 0.041 0.0395
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0142 0.1078
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0114 0.1059 0.1059
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0114 0.1059 0.1059
Echinococcus multilocularis neuropeptide s receptor 0.0508 0.523 0.523
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0125 0.0109
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0114 0.1059 0.1031
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0016 0.0016
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0043 0.0055
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0031 0.0015
Leishmania major hypothetical protein, conserved 0.0114 0.1059 0.1031
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0043 0.0055
Leishmania major cathepsin L-like protease 0.007 0.0591 0.0562
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0125 0.0125
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0591 0.0562
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0958 1 1
Brugia malayi hypothetical protein 0.004 0.0267 0.0252
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0043 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0125 0.0109
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0125 0.0125
Schistosoma mansoni lamin 0.003 0.0162 0.0147
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0533 0.0533
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0125 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0125 0.0109
Schistosoma mansoni lozenge 0.0061 0.0495 0.048
Onchocerca volvulus 0.0018 0.0043 0.0055
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0114 0.1059 0.2091
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0125 0.0109
Echinococcus multilocularis neuropeptide receptor A26 0.0508 0.523 0.523
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0043 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0125 0.0109
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0043 0.012
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0533 0.0533
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0125 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0429 0.0413
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0267 0.0267
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0114 0.1059 0.1031
Leishmania major cathepsin L-like protease 0.007 0.0591 0.0562
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0114 0.1059 0.102
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0958 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0533 0.0533
Leishmania major cathepsin L-like protease 0.0018 0.0043 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0162 0.0162
Leishmania major eukaryotic translation initiation factor-like 0.0958 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1059 0.102
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0114 0.1059 0.102
Leishmania major cathepsin L-like protease 0.007 0.0591 0.0562
Brugia malayi intermediate filament protein 0.003 0.0162 0.0147
Brugia malayi nuclear receptor NHR-88 0.0026 0.0125 0.0109
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0031 0.0031
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0114 0.1059 0.102
Entamoeba histolytica hypothetical protein 0.004 0.0267 0.0225
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0031 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Leishmania major eukaryotic translation initiation factor-like protein 0.0958 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0125
Giardia lamblia Hypothetical protein 0.0114 0.1059 0.5
Schistosoma mansoni hypothetical protein 0.0186 0.1821 0.1808
Leishmania major hypothetical protein, conserved 0.0114 0.1059 0.1031
Brugia malayi jmjC domain containing protein 0.0065 0.0533 0.0518
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0114 0.1059 0.1031
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0112 0.0112
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0114 0.1059 0.102
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0028
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0031 0.0031
Loa Loa (eye worm) cysteine protease 0.0018 0.0043 0.0043
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0142 0.0111
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0533 0.0518
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0032 0.0032
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0016 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0032 0.0032
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0958 1 1
Leishmania major cathepsin L-like protease 0.0018 0.0043 0.0012
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0043 0.012
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.7879 0.7879
Echinococcus multilocularis cysteine protease 0.0018 0.0043 0.0043
Echinococcus granulosus survival motor neuron protein 1 0.026 0.26 0.26
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0114 0.1059 0.102
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0125 0.0109
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0043 0.0043
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0114 0.1059 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0245 0.023
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0958 1 1
Echinococcus multilocularis Ankyrin 0.0016 0.0017 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0043 0.0028
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0031 0.0031
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0142 0.0111
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0114 0.1059 0.1045
Loa Loa (eye worm) fibroinase 0.0018 0.0043 0.0043
Onchocerca volvulus 0.0018 0.0043 0.0055
Schistosoma mansoni hypothetical protein 0.0017 0.0032 0.0016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0125
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0016 0.0016
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0028
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0017 0.0017
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0114 0.1059 0.1031
Schistosoma mansoni lamin 0.003 0.0162 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0381 0.0381
Loa Loa (eye worm) ctsf protein 0.0018 0.0043 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0125 0.0125
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0028
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0125 0.0109
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0017 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0032 0.0032
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0432 0.0402
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0142 0.0111
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0125
Schistosoma mansoni intermediate filament proteins 0.003 0.0162 0.0147
Brugia malayi hypothetical protein 0.0018 0.0038 0.0022
Echinococcus multilocularis musashi 0.003 0.0162 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Loa Loa (eye worm) hypothetical protein 0.0028 0.0142 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0591 0.0562
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0381 0.0381
Brugia malayi hypothetical protein 0.0179 0.1748 0.1735
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0032 0.0016
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.7879 0.7876
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0114 0.1059 0.1045
Onchocerca volvulus 0.0018 0.0043 0.0055
Loa Loa (eye worm) hypothetical protein 0.0487 0.5003 0.5003
Echinococcus multilocularis GPCR, family 2 0.0017 0.0032 0.0032
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.26 0.26
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0114 0.1059 0.1031
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0125 0.0109
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0032 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0125 0.0109
Brugia malayi Cathepsin L-like precursor 0.0018 0.0043 0.0028
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0125 0.0125
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0114 0.1059 0.1031
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0043 0.0012
Onchocerca volvulus 0.0053 0.041 0.079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0125 0.0109
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0125 0.0125

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) = 0.4 mg kg-1 Trypanocidal Activity at I.C.E. value 0.67 when administered subcutaneously. ChEMBL. 2296025
CD50 (functional) = 0.4 mg kg-1 Trypanocidal Activity at I.C.E. value 0.67 when administered subcutaneously. ChEMBL. 2296025

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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