Detailed information for compound 173445

Basic information

Technical information
  • TDR Targets ID: 173445
  • Name: 4-[[4-amino-6-(cyclohexylmethoxy)pyrimidin-2- yl]amino]benzenesulfonamide
  • MW: 377.461 | Formula: C17H23N5O3S
  • H donors: 3 H acceptors: 4 LogP: 2.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cc(OCC2CCCCC2)nc(n1)Nc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C17H23N5O3S/c18-15-10-16(25-11-12-4-2-1-3-5-12)22-17(21-15)20-13-6-8-14(9-7-13)26(19,23)24/h6-10,12H,1-5,11H2,(H2,19,23,24)(H3,18,20,21,22)
  • InChiKey: ALNJIRVGTQKZMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[4-amino-6-(cyclohexylmethoxy)-2-pyrimidinyl]amino]benzenesulfonamide
  • 4-[[4-azanyl-6-(cyclohexylmethoxy)pyrimidin-2-yl]amino]benzenesulfonamide
  • 2-arylamino-pyrimidine deriv. 8b

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens cyclin A2 No references
Homo sapiens cyclin A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis SWI:SNF matrix associated 0.0644 0.9674 0.9674
Loa Loa (eye worm) hypothetical protein 0.0032 0.0323 0.0333
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0634 0.0656
Echinococcus multilocularis zinc finger protein Ran binding 0.0229 0.3337 0.3337
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0012 0.0016 0.0016
Leishmania major hypothetical protein, conserved 0.0229 0.3337 1
Brugia malayi RING finger protein 20 0.0012 0.0016 0.0017
Echinococcus granulosus cyclins 0.0038 0.0411 0.0411
Giardia lamblia Kinase, NEK 0.0012 0.0025 0.0071
Echinococcus multilocularis cyclin B 0.009 0.1213 0.1213
Chlamydia trachomatis SWIB complex protein 0.0644 0.9674 0.5
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0644 0.9674 0.9674
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0634 0.0656
Echinococcus multilocularis cyclins 0.0038 0.0411 0.0411
Echinococcus multilocularis SWI:SNF matrix associated 0.0644 0.9674 0.9674
Brugia malayi hypothetical protein 0.0012 0.0016 0.0017
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0396 0.0396
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0396 0.041
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0634 0.0634
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0229 0.3337 0.345
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0229 0.3337 1
Trypanosoma brucei hypothetical protein, conserved 0.0229 0.3337 1
Echinococcus multilocularis cyclins 0.0038 0.0411 0.0411
Brugia malayi hypothetical protein 0.0012 0.0016 0.0017
Echinococcus granulosus cyclins 0.0038 0.0411 0.0411
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0634 0.1861
Giardia lamblia Kinase, NEK 0.0012 0.0025 0.0071
Trypanosoma cruzi cyclin, putative 0.009 0.1213 0.3603
Loa Loa (eye worm) hypothetical protein 0.009 0.1213 0.1254
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0229 0.3337 1
Trichomonas vaginalis cyclin B, putative 0.009 0.1213 0.1239
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0634 0.5165
Giardia lamblia Cyclin A 0.0038 0.0411 0.3301
Trichomonas vaginalis cyclins, putative 0.009 0.1213 0.1239
Schistosoma mansoni cyclin B3 0.0038 0.0411 0.0425
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0396 0.0396
Plasmodium vivax protein kinase Crk2 0.0052 0.0634 0.064
Brugia malayi cell division control protein 2 homolog 0.0052 0.0634 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0644 0.9674 1
Leishmania major hypothetical protein, conserved 0.0229 0.3337 1
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0634 0.0634
Schistosoma mansoni hypothetical protein 0.0012 0.0016 0.0017
Schistosoma mansoni rnf5 0.0012 0.0016 0.0017
Echinococcus granulosus SWI:SNF matrix associated 0.0644 0.9674 0.9674
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0012 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0644 0.9674 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0229 0.3337 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0411 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0634 0.0656
Trichomonas vaginalis cyclin B, putative 0.0038 0.0411 0.0409
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0634 0.1861
Trichomonas vaginalis cyclin D, putative 0.0038 0.0411 0.0409
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0634 0.1861
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0229 0.3337 0.3438
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0634 0.0634
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Echinococcus multilocularis cyclins 0.0038 0.0411 0.0411
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0634 0.064
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0012 0.0016 0.0016
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0634 0.1861
Trypanosoma brucei hypothetical protein, conserved 0.0229 0.3337 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0634 0.5165
Schistosoma mansoni cyclin B 0.009 0.1213 0.1254
Trichomonas vaginalis cyclin B, putative 0.009 0.1213 0.1239
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0012 0.0016 0.0016
Echinococcus granulosus zinc finger protein Ran binding 0.0229 0.3337 0.3337
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0634 0.064
Onchocerca volvulus 0.0644 0.9674 1
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0012 0.0016 0.0016
Onchocerca volvulus 0.009 0.1213 0.1239
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0644 0.9674 1
Schistosoma mansoni RNA binding protein 0.0229 0.3337 0.345
Schistosoma mansoni peter pan-related 0.0012 0.0016 0.0017
Entamoeba histolytica cyclin, putative 0.0038 0.0411 0.3301
Plasmodium falciparum protein kinase 5 0.0052 0.0634 0.064
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0229 0.3337 1
Echinococcus multilocularis tumor protein p63 0.0665 1 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0644 0.9674 1
Toxoplasma gondii hypothetical protein 0.0028 0.0273 0.0266
Echinococcus multilocularis cyclins 0.0038 0.0411 0.0411
Entamoeba histolytica cyclin, putative 0.009 0.1213 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0634 0.064
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0229 0.3337 0.345
Plasmodium vivax hypothetical protein, conserved 0.0644 0.9674 1
Schistosoma mansoni hypothetical protein 0.0644 0.9674 1
Trichomonas vaginalis cyclins, putative 0.0062 0.0778 0.0789
Schistosoma mansoni cellular tumor antigen P53 0.0097 0.1326 0.137
Onchocerca volvulus 0.0229 0.3337 0.3438
Trichomonas vaginalis cyclins, putative 0.009 0.1213 0.1239
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0012 0.0016 0.0016
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0447 0.0463
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0644 0.9674 1
Trichomonas vaginalis cyclins, putative 0.009 0.1213 0.1239
Chlamydia trachomatis DNA topoisomerase I 0.0644 0.9674 0.5
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0012 0.0016 0.0016
Schistosoma mansoni fusion 0.0229 0.3337 0.345
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.036 0.0355
Echinococcus granulosus Zinc finger RanBP2 type 0.0229 0.3337 0.3337
Trypanosoma cruzi cyclin 6, putative 0.009 0.1213 0.3603
Echinococcus granulosus ring finger protein 170 0.0012 0.0016 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0025 0.0026
Brugia malayi Neuralized family protein 0.0012 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Brugia malayi Zinc finger, C2H2 type family protein 0.0012 0.0016 0.0017
Loa Loa (eye worm) RiNg Finger protein family member 0.0012 0.0016 0.0017
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0634 0.0634
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0229 0.3337 1
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0447 0.0463
Schistosoma mansoni ring finger protein 151 0.0012 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.064 0.0662
Leishmania major hypothetical protein, conserved 0.0229 0.3337 1
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0052 0.0626 0.0647
Echinococcus multilocularis cyclin B3 1 0.0038 0.0411 0.0411
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.1213 0.3603
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0229 0.3337 0.3438
Schistosoma mansoni hypothetical protein 0.0012 0.0016 0.0017
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0634 0.1861
Brugia malayi B-box zinc finger family protein 0.0012 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Trichomonas vaginalis cyclins, putative 0.009 0.1213 0.1239
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0634 0.1861
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.1213 0.1254
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0229 0.3337 0.3337
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0229 0.3337 0.345
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0012 0.0016 0.0017
Brugia malayi hypothetical protein 0.0012 0.0016 0.0017
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0644 0.9674 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.0411 0.0411
Echinococcus multilocularis ring finger protein 113a 0.0012 0.0016 0.0016
Plasmodium falciparum cyclin 0.0038 0.0411 0.0409
Loa Loa (eye worm) hypothetical protein 0.0229 0.3337 0.345
Echinococcus granulosus cell growth regulator with ring finger domain 0.0012 0.0016 0.0016
Giardia lamblia Hypothetical protein 0.0038 0.0411 0.3301
Echinococcus multilocularis RING finger protein 185 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.009 0.1213 0.1254
Trypanosoma cruzi hypothetical protein, conserved 0.0229 0.3337 1
Giardia lamblia Kinase 0.0012 0.0025 0.0071
Echinococcus granulosus cyclin B3 1 0.0038 0.0411 0.0411
Trypanosoma cruzi cyclin, putative 0.009 0.1213 0.3603
Loa Loa (eye worm) hypothetical protein 0.0229 0.3337 0.345
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0634 0.0634
Trichomonas vaginalis cyclins, putative 0.0038 0.0411 0.0409
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0411 0.0425
Loa Loa (eye worm) hypothetical protein 0.0229 0.3337 0.345
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0644 0.9674 1
Entamoeba histolytica cyclin family protein 0.0038 0.0411 0.3301
Echinococcus multilocularis SWI:SNF matrix associated 0.0644 0.9674 0.9674
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0644 0.9674 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.0411 0.0411
Echinococcus multilocularis 0.0012 0.0016 0.0016
Echinococcus multilocularis cyclins 0.0038 0.0411 0.0411
Schistosoma mansoni TRABID protein (C64 family) 0.0229 0.3337 0.345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Brugia malayi hypothetical protein 0.0012 0.0016 0.0017
Echinococcus granulosus ring finger protein 113a 0.0012 0.0016 0.0016
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0634 0.1861
Echinococcus multilocularis cyclins 0.0038 0.0411 0.0411
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0634 0.0656
Trichomonas vaginalis cyclin B, putative 0.009 0.1213 0.1239
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0396 0.041
Trichomonas vaginalis cyclin A, putative 0.009 0.1213 0.1239
Trichomonas vaginalis cyclin B, putative 0.009 0.1213 0.1239
Onchocerca volvulus 0.0229 0.3337 0.3438
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0229 0.3337 0.3438
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0012 0.0016 0.0016
Brugia malayi hypothetical protein 0.0012 0.0016 0.0017
Schistosoma mansoni brg-1 associated factor 0.0644 0.9674 1
Brugia malayi YY1-associated factor 2 0.0229 0.3337 0.345
Loa Loa (eye worm) RING finger protein 20 0.0012 0.0016 0.0017
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0012 0.0016 0.0017
Schistosoma mansoni mind bomb 0.0012 0.0016 0.0017
Brugia malayi brahma associated protein 60 kDa 0.0644 0.9674 1
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0012 0.0016 0.0016
Leishmania major hypothetical protein, conserved 0.0229 0.3337 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.0634 0.0656
Schistosoma mansoni hypothetical protein 0.0229 0.3337 0.345
Echinococcus granulosus RING finger protein 185 0.0012 0.0016 0.0016
Brugia malayi Zinc finger protein 183 homolog 0.0012 0.0016 0.0017
Echinococcus granulosus cyclin B 0.009 0.1213 0.1213
Trypanosoma cruzi hypothetical protein, conserved 0.0229 0.3337 1
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0097 0.1326 0.1356
Echinococcus granulosus cyclins 0.0038 0.0411 0.0411
Loa Loa (eye worm) brahma associated protein 0.0644 0.9674 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0229 0.3337 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0229 0.3337 0.345
Trichomonas vaginalis cyclin B3, putative 0.0038 0.0411 0.0409
Echinococcus multilocularis cyclins 0.0038 0.0411 0.0411
Trypanosoma brucei mitotic cyclin 6 0.009 0.1213 0.3603
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0229 0.3337 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0634 0.5165
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.1213 0.3603
Echinococcus granulosus cyclin b3 0.0038 0.0411 0.0411
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0634 0.1861
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0634 0.0656
Schistosoma mansoni hypothetical protein 0.0012 0.0016 0.0017
Entamoeba histolytica cyclin family protein 0.0038 0.0411 0.3301
Leishmania major hypothetical protein, conserved 0.0229 0.3337 1
Schistosoma mansoni hypothetical protein 0.0644 0.9674 1
Echinococcus granulosus cyclins 0.0038 0.0411 0.0411
Onchocerca volvulus 0.0229 0.3337 0.3438
Trichomonas vaginalis cyclin D, putative 0.0038 0.0411 0.0409
Brugia malayi hypothetical protein 0.0012 0.0016 0.0017
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0229 0.3337 0.3337
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Schistosoma mansoni peter pan-related 0.0012 0.0016 0.0017
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0634 0.064
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.0411 0.0425
Brugia malayi brahma associated protein 60 kDa 0.0644 0.9674 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.3337 0.345
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0644 0.9674 0.9674
Schistosoma mansoni cyclins 0.0038 0.0411 0.0425
Echinococcus granulosus cyclins 0.0038 0.0411 0.0411
Echinococcus multilocularis cyclin b3 0.0038 0.0411 0.0411
Brugia malayi RING zinc finger protein 0.0012 0.0016 0.0017
Echinococcus multilocularis ring finger protein 170 0.0012 0.0016 0.0016
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0229 0.3337 0.345
Loa Loa (eye worm) hypothetical protein 0.0097 0.1326 0.137
Toxoplasma gondii ran binding protein 0.0229 0.3337 0.3438
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0012 0.0016 0.0016
Schistosoma mansoni zinc finger protein 0.0229 0.3337 0.345
Echinococcus granulosus ring and YY1 binding protein 0.0229 0.3337 0.3337
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.1213 0.1254
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0634 0.5165
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0634 0.0634
Echinococcus multilocularis ring and YY1 binding protein 0.0229 0.3337 0.3337
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.1213 1
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0229 0.3337 0.3337
Brugia malayi SWIB/MDM2 domain containing protein 0.0644 0.9674 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0017
Trypanosoma cruzi WLM domain containing protein, putative 0.0229 0.3337 1
Leishmania major cyclin 0.009 0.1213 0.3603
Schistosoma mansoni zinc finger protein 0.0012 0.0016 0.0017
Onchocerca volvulus 0.0229 0.3337 0.3438
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.036 0.0355
Trypanosoma cruzi hypothetical protein, conserved 0.0229 0.3337 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0229 0.3337 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2930 nM Inhibition of CDK2/cyclinA (unknown origin) ChEMBL. No reference
IC50 (binding) = 2.9 uM Inhibition of Cyclin-dependent kinase 2 (CDK2) at 12.5 uM ATP ChEMBL. 12941338
IC50 (binding) = 2.9 uM Inhibition of Cyclin-dependent kinase 2 (CDK2) at 12.5 uM ATP ChEMBL. 12941338
IC50 (binding) = 5.3 uM Inhibition of Cyclin-dependent kinase 1 (CDK1) at 12.5 uM ATP ChEMBL. 12941338
IC50 (binding) = 5.3 uM Inhibition of Cyclin-dependent kinase 1 (CDK1) at 12.5 uM ATP ChEMBL. 12941338

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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