Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | threonyl-tRNA synthetase | Starlite/ChEMBL | References |
Yersinia pestis | Threonine--tRNA ligase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Threonine--tRNA ligase | 642 aa | 630 aa | 39.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | threonine--tRNA ligase | 0.0059 | 0.8119 | 0.5 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0059 | 0.8119 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0025 | 0 | 0.5 |
Chlamydia trachomatis | threonine--tRNA ligase | 0.0067 | 1 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Schistosoma mansoni | threonyl-tRNA synthetase | 0.0053 | 0.6773 | 1 |
Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0059 | 0.8119 | 0.5 |
Leishmania major | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 0.5 |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0059 | 0.8119 | 0.5 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 0.5 |
Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0059 | 0.8119 | 0.5 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0059 | 0.8119 | 0.5 |
Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0059 | 0.8119 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0059 | 0.8119 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0059 | 0.8119 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0059 | 0.8119 | 0.5 |
Plasmodium vivax | threonine--tRNA ligase, putative | 0.0059 | 0.8119 | 0.5 |
Onchocerca volvulus | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.