TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 485.397 | Formula: C22H21BrN4O2S
H donors: 1 H acceptors: 2 LogP: 5.49 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)S(=O)(=O)N/N=C/c1ccc(cc1)c1cn2c([n+]1C)cccc2.[Br-]
InChi: 1S/C22H21N4O2S.BrH/c1-17-6-12-20(13-7-17)29(27,28)24-23-15-18-8-10-19(11-9-18)21-16-26-14-4-3-5-22(26)25(21)2;/h3-16,24H,1-2H3;1H/q+1;/p-1/b23-15+;
InChiKey: YDDGVMUJKLWDHN-BUGNPGDCSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0116	0.0116
Echinococcus granulosus	endoplasmin	0.0026	0.0079	0.0079
Leishmania major	heat shock protein, putative	0.0013	0.0027	0.0027
Brugia malayi	CHE-14 protein	0.0042	0.0146	0.0146
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0027	0.5848
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.007	0.8871
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E-1	0.029	0.1168	0.1168
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0128	0.1093
Toxoplasma gondii	heat shock protein HSP90	0.0032	0.0106	0.0106
Brugia malayi	Thioredoxin reductase	0.0038	0.0128	0.0128
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0001	0.0001
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0146	0.0146
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.0027
Onchocerca volvulus		0.0007	0.0001	0.0012
Schistosoma mansoni	cpg binding protein	0.0028	0.009	0.009
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0009	0.0009
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.007	0.1914
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0045	0.576
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0007	0.0001	0.0177
Echinococcus granulosus	nibrin	0.001	0.0013	0.0013
Brugia malayi	beta-NAC-like protein	0.0035	0.0116	0.0116
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.029	0.1168	0.1168
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.2432	1	1
Leishmania major	hypothetical protein, conserved	0.029	0.1168	0.1168
Mycobacterium tuberculosis	Probable oxidoreductase	0.0095	0.0365	1
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0032	0.0106	0.0906
Brugia malayi	heat shock protein 90	0.0032	0.0106	0.0106
Plasmodium falciparum	thioredoxin reductase	0.0013	0.0027	0.0227
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.0001	0.0001
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.029	0.1168	0.1168
Echinococcus multilocularis	heat shock protein 90	0.0032	0.0106	0.0106
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.2432	1	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0086	0.0326	0.8922
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.029	0.1168	0.1168
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0001	0.0001
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0013	0.1674
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0013
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0024	0.007	0.007
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Entamoeba histolytica	eukaryotic initiation factor 4E, putative	0.029	0.1168	0.1168
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.029	0.1168	0.1168
Mycobacterium ulcerans	heat shock protein 90	0.0026	0.0079	1
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0013	0.0013
Schistosoma mansoni	cpg binding protein	0.003	0.0097	0.0097
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0146	0.0146
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0027	0.0027
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Toxoplasma gondii	Hsp90 domain-containing protein	0.0013	0.0027	0.0027
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0012	0.0012
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0382	0.0382
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.007	0.8871
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0026	0.0079	0.0079
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0001	0.0001
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0013	0.0013
Trichomonas vaginalis	hypothetical protein	0.029	0.1168	0.1168
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0002	0.0002
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.0079	0.0079
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.016	0.016
Plasmodium vivax	hypothetical protein, conserved	0.029	0.1168	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.007	0.007
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.004	0.014	0.014
Trypanosoma brucei	trypanothione reductase	0.0038	0.0128	0.0128
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0007	0.0001	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0024	0.007	0.007
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0013	0.0013
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0001	0.0177
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0026	0.0079	0.0079
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0086	0.0326	0.8922
Loa Loa (eye worm)	eukaryotic translation initiation factor 4E type 3	0.029	0.1168	0.1168
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.007	0.007
Leishmania major	eukaryotic translation initiation factor-like	0.2432	1	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0002	0.0002
Brugia malayi	Hsp90 protein	0.0013	0.0027	0.0027
Trypanosoma cruzi	heat shock protein, putative	0.0013	0.0027	0.0027
Echinococcus multilocularis	heat shock protein	0.0032	0.0106	0.0106
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0045	0.0388
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.007	0.007
Echinococcus granulosus	eukaryotic translation initiation factor 4E type	0.029	0.1168	0.1168
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0106	0.0106
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0013	0.0013
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0001	0.0001
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.0027	0.3368
Trichomonas vaginalis	conserved hypothetical protein	0.029	0.1168	0.1168
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0001	0.0001
Toxoplasma gondii	NAC domain-containing protein	0.0035	0.0116	0.0116
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Brugia malayi	Endoplasmin precursor	0.0032	0.0106	0.0106
Schistosoma mansoni	heat shock protein	0.0032	0.0106	0.0106
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0013	0.0027	0.0227
Schistosoma mansoni	hypothetical protein	0.0011	0.0019	0.0019
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0001	0.0038
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.016	0.016
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0001	0.0177
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0013	0.0027	0.0027
Entamoeba histolytica	heat shock protein 90, putative	0.0032	0.0106	0.0106
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0095	0.0365	1
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0013	0.0013
Onchocerca volvulus		0.0024	0.007	0.0598
Leishmania major	trypanothione reductase	0.0038	0.0128	0.0128
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0045	0.0045
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0001	0.0001
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.007	0.8871
Plasmodium falciparum	glutathione reductase	0.0013	0.0027	0.0227
Plasmodium vivax	endoplasmin, putative	0.0032	0.0106	0.0906
Giardia lamblia	Grp94/Hsp90	0.0026	0.0079	0.0674
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0007	0.0001	0.0038
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0013	0.0013
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0001	0.0001
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0076	0.0076
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0027	0.0027
Plasmodium falciparum	heat shock protein 90, putative	0.0013	0.0027	0.0235
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.2432	1	1
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Echinococcus granulosus	heat shock protein 90	0.0032	0.0106	0.0106
Onchocerca volvulus		0.0007	0.0001	0.0012
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0106	0.0106
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0076	0.0651
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0001	0.0038
Treponema pallidum	NADH oxidase	0.0013	0.0027	0.3368
Brugia malayi	hypothetical protein	0.0016	0.0039	0.0039
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0001	0.0038
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.007	0.8871
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0128	0.1093
Echinococcus multilocularis	endoplasmin	0.0026	0.0079	0.0079
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0019	0.0019
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0076	0.0076
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-3	0.029	0.1168	0.1168
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0076	0.0076
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0001	0.0038
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0001	0.0038
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0001	0.0001
Schistosoma mansoni	cpg binding protein	0.003	0.0097	0.0097
Echinococcus multilocularis	nibrin	0.001	0.0013	0.0013
Schistosoma mansoni	topbp1	0.001	0.0013	0.0013
Brugia malayi	hypothetical protein	0.001	0.0013	0.0013
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.2432	1	1
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.0027	0.3368
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0128	0.0128
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.016
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.0027	0.0027
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0027	0.0027
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0106	0.0106
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0146	0.0146
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0079	0.0079
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0013	0.1674
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0106	0.0106
Toxoplasma gondii	heat shock protein 90, putative	0.0032	0.0106	0.0106
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.029	0.1168	0.1168
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.029	0.1168	0.1168
Echinococcus multilocularis	Niemann Pick C1 protein	0.014	0.0549	0.0549
Schistosoma mansoni	endoplasmin	0.0032	0.0106	0.0106
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.007	0.1914
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Trypanosoma brucei	heat shock protein 90, putative	0.0032	0.0106	0.0106
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.007	0.8871
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0185	0.0185
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0045	0.0045
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0007	0.0001	0.0038
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0106	0.0106
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.0116	0.0116
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0001	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0116	0.0116
Trypanosoma brucei	Heat shock protein 83, putative	0.0032	0.0106	0.0106
Trypanosoma cruzi	heat shock protein 90, putative	0.0032	0.0106	0.0106
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-4	0.029	0.1168	0.1168
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0007	0.0001	0.0177
Schistosoma mansoni	topbp1	0.001	0.0013	0.0013
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0012	0.0012
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0001	0.0038
Echinococcus granulosus	cpg binding protein	0.003	0.0097	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0013	0.0013
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.007	0.1914
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0027	0.0027
Echinococcus multilocularis	cpg binding protein	0.003	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0045	0.0045
Plasmodium falciparum	endoplasmin, putative	0.002	0.0054	0.0466
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0001	0.0177
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.0116	0.0116
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0027	0.0027
Entamoeba histolytica	hypothetical protein	0.029	0.1168	0.1168
Loa Loa (eye worm)	translation initiation factor 4E	0.2432	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0001	0.0177
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0013
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0027	0.0027
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.2432	1	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0086	0.0326	0.8922
Plasmodium falciparum	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0076	0.0651
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.007	0.8871
Onchocerca volvulus		0.0028	0.009	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0076	0.0076
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0013	0.0113
Entamoeba histolytica	hypothetical protein	0.029	0.1168	0.1168
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0013	0.0013
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Trypanosoma brucei	heat shock protein 90, putative	0.0032	0.0106	0.0106
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.029	0.1168	0.1168
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0001	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0024	0.007	0.007
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0027	0.0027
Plasmodium vivax	heat shock protein, putative	0.0013	0.0027	0.0235
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0007	0.0001	0.0001
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0001	0.0001
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0196	0.0196
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.007	0.8871
Leishmania major	eukaryotic translation initiation factor, putative	0.029	0.1168	0.1168
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-2	0.029	0.1168	0.1168
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0002	0.0002
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0013
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0013	0.0013
Schistosoma mansoni	heat shock protein	0.0013	0.0027	0.0027
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0116	0.0116
Leishmania major	eukaryotic translation initiation factor 4e, putative	0.029	0.1168	0.1168
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.009	0.009
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0013	0.0013
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0007	0.0001	0.0177
Trichomonas vaginalis	heat shock protein, putative	0.0032	0.0106	0.0106
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.2432	1	1
Leishmania major	basic transcription factor 3a, putative	0.0035	0.0116	0.0116
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0002	0.0002
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0001	0.0001
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0128	0.0128
Treponema pallidum	DNA ligase (lig)	0.001	0.0013	0.1674
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0001	0.0001
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0079	0.0079
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.007	0.1914
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.0027	0.0027
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.0116	0.0992
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-3	0.029	0.1168	0.1168
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0106	0.0106
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.2432	1	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.2432	1	1
Schistosoma mansoni	endoplasmin	0.0032	0.0106	0.0106
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0079	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.029	0.1168	0.1168
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0027	0.0027
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0086	0.0326	0.8922
Plasmodium vivax	heat shock protein 90, putative	0.0013	0.0027	0.0235
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0001	0.0001
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0009	0.0009
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.0116	0.0116
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0095	0.0365	1
Brugia malayi	glutathione reductase	0.0038	0.0128	0.0128
Schistosoma mansoni	DNA ligase IV	0.001	0.0013	0.0013
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.0376	0.0376
Giardia lamblia	Hypothetical protein	0.029	0.1168	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.0376	0.0376
Plasmodium falciparum	eukaryotic translation initiation factor 4E	0.029	0.1168	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0019	0.0019
Schistosoma mansoni	hypothetical protein	0.0406	0.1646	0.1646
Toxoplasma gondii	hypothetical protein	0.029	0.1168	0.1168
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0106	0.0106
Echinococcus multilocularis	transcription factor btf3	0.0035	0.0116	0.0116
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0013	0.0013
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0013	0.0027	0.0227
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0026	0.0079	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0001	0.0038
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0026	0.0079	0.0674
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0128	0.0128
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0026	0.0079	0.2157
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.016	0.016
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-4	0.029	0.1168	0.1168
Schistosoma mansoni	hypothetical protein	0.004	0.014	0.014
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.007	0.007
Brugia malayi	hypothetical protein	0.001	0.0013	0.0013
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.007	0.007
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0054	0.0054
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0106	0.0106
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0013	0.0013
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0001	0.0001
Echinococcus multilocularis	protein dispatched 1	0.0048	0.017	0.017
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.0376	0.0376
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0041	0.1134
Schistosoma mansoni	patched 1	0.0042	0.0146	0.0146
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0001	0.0038
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.2432	1	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0001	0.0001
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.007	0.007
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0001	0.0001
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0376	0.0376
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0009	0.0009
Echinococcus granulosus	dnaJ subfamily B	0.0406	0.1646	0.1646
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0027	0.0027
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0041	0.1134
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0007	0.0001	0.0177
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0013	0.0013
Mycobacterium tuberculosis	Probable reductase	0.0086	0.0326	0.8922
Brugia malayi	eukaryotic translation initiation factor 4E-1	0.029	0.1168	0.1168
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0041	0.1134
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.029	0.1168	0.1168
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.016	0.016
Giardia lamblia	hypothetical protein	0.029	0.1168	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E type 5, putative	0.029	0.1168	0.1168
Plasmodium falciparum	heat shock protein 90	0.0032	0.0106	0.0906
Schistosoma mansoni	transcription factor btf3	0.0035	0.0116	0.0116
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.2432	1	1
Brugia malayi	CXXC zinc finger family protein	0.0028	0.009	0.009
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0128	0.0128
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.0116	0.0992
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0013	0.0027	0.0227
Toxoplasma gondii	heat shock protein 75, putative	0.0013	0.0027	0.0027
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0013	0.0013
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0026	0.0079	0.2157
Treponema pallidum	heat shock protein 90	0.0026	0.0079	1
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0027	0.0027
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.3368
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.001	0.0013	0.0013
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.0001	0.0012
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0001	0.0177
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0001	0.0001
Trypanosoma brucei	Eukaryotic translation initiation factor 4E type 5	0.029	0.1168	0.1168
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.0027
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0106	0.0106
Brugia malayi	hypothetical protein	0.0025	0.0076	0.0076
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.2432	1	1
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0001	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0146	0.0146
Echinococcus granulosus	heat shock protein	0.0032	0.0106	0.0106
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0013	0.0027	0.0227
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.016	0.016
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0001	0.0001
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0013	0.0013
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0013	0.0361
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0007	0.0001	0.0038
Entamoeba histolytica	translation initiation factor 4e, putative	0.029	0.1168	0.1168
Trichomonas vaginalis	conserved hypothetical protein	0.029	0.1168	0.1168
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.2432	1	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0146	0.0146
Brugia malayi	DKFZp564C0469 protein	0.001	0.0013	0.0013
Onchocerca volvulus	Putative eukaryotic translation initiation factor 4e	0.029	0.1168	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0009	0.0009
Echinococcus multilocularis	protein patched	0.0042	0.0146	0.0146
Echinococcus granulosus	expressed conserved protein	0.0092	0.0351	0.0351
Schistosoma mansoni	heat shock protein	0.0032	0.0106	0.0106
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0106	0.0106
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0013	0.0027	0.0227
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0128	0.1093
Leishmania major	eukaryotic translation initiation factor-like protein	0.2432	1	1
Chlamydia trachomatis	DNA ligase	0.001	0.0013	0.2907
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0076	0.0651
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.0128	0.3495
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0001	0.0177
Mycobacterium ulcerans	acyl-CoA synthetase	0.0007	0.0001	0.0177
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.016
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0013	0.0113
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.0027	0.0027
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0079	0.0079
Leishmania major	hypothetical protein, conserved	0.029	0.1168	0.1168
Entamoeba histolytica	eukaryotic initiation factor 4E, putative	0.029	0.1168	0.1168
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.013	0.013
Loa Loa (eye worm)	heat shock protein 75	0.0013	0.0027	0.0027
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0007	0.0001	0.0177
Plasmodium vivax	translation initiation factor 4E, putative	0.029	0.1168	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0045	0.0388
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.007	0.007
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0007	0.0001	0.0177
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.0001	0.0001
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0013	0.0027	0.0027
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0045	0.1243
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0013	0.0027	0.0027
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Echinococcus multilocularis	expressed conserved protein	0.0092	0.0351	0.0351
Brugia malayi	topoisomerase	0.001	0.0013	0.0013
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0013	0.0013
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.0001	0.0001
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0013
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.0001	0.0012
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0013	0.0027	0.0027
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0045	0.0045
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0086	0.0326	0.8922
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0045	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0001	0.0001
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0027	0.0027
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0013	0.0013
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.2432	1	1
Entamoeba histolytica	heat shock protein 90, putative	0.0032	0.0106	0.0106
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0041	0.1134
Echinococcus multilocularis	dnaJ subfamily B	0.0406	0.1646	0.1646
Giardia lamblia	Translation elongation factor	0.029	0.1168	1
Echinococcus granulosus	heat shock protein 90	0.0026	0.0079	0.0079
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0007	0.0001	0.0177
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.2432	1	1
Onchocerca volvulus		0.001	0.0013	0.0113
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.001	0.0013	0.0013
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0027	0.3368
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0013	0.0027	0.0727
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0001	0.0001
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0027	0.0027
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0002	0.0002
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.0027
Plasmodium falciparum	heat shock protein 90, putative	0.0013	0.0027	0.0235
Schistosoma mansoni	hypothetical protein	0.004	0.014	0.014
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0001	0.0001
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0027	0.3368
Mycobacterium ulcerans	hypothetical protein	0.0024	0.007	0.8871
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0007	0.0001	0.0177
Giardia lamblia	Hypothetical protein	0.029	0.1168	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Echinococcus granulosus	Niemann Pick C1 protein	0.014	0.0549	0.0549
Trypanosoma cruzi	Heat shock protein 83, putative	0.0032	0.0106	0.0106
Brugia malayi	Eukaryotic translation initiation factor 4E type 3, putative	0.029	0.1168	0.1168
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.016	0.016
Schistosoma mansoni	hypothetical protein	0.004	0.014	0.014
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0095	0.0365	1
Echinococcus granulosus	transcription factor btf3	0.0035	0.0116	0.0116
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0013	0.0027	0.0235
Loa Loa (eye worm)	heat shock protein 90	0.0032	0.0106	0.0106
Leishmania major	hypothetical protein, conserved	0.0025	0.0076	0.0076
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0222	0.0222
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0001	0.0038
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0076	0.0076
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.0027
Echinococcus multilocularis	heat shock protein 90	0.0026	0.0079	0.0079
Loa Loa (eye worm)	endoplasmin	0.0032	0.0106	0.0106
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0027	0.0027
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.0376	0.0376
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0001	0.0038
Mycobacterium tuberculosis	Probable dehydrogenase	0.0086	0.0326	0.8922
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0013	0.0027	0.0027
Trichomonas vaginalis	eukaryotic translation initiation factor 4E type, putative	0.029	0.1168	0.1168
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0001	0.0001
Trypanosoma cruzi	eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative	0.029	0.1168	0.1168
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0013	0.0013
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0054	0.0054
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0805	0.329	0.329
Trypanosoma brucei	heat shock protein 84, putative	0.0013	0.0027	0.0027
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.016	0.016
Plasmodium vivax	heat shock protein 86, putative	0.0032	0.0106	0.0906
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.029	0.1168	0.1168
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0146	0.0146
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.0116	0.0116
Onchocerca volvulus		0.0007	0.0001	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0013	0.0013
Plasmodium falciparum	glutathione reductase	0.0038	0.0128	0.1093
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0013	0.0113
Trichomonas vaginalis	heat shock protein, putative	0.0013	0.0027	0.0027
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Onchocerca volvulus		0.0007	0.0001	0.0012
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Entamoeba histolytica	hypothetical protein	0.0035	0.0116	0.0116
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0027	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.007	0.007
Leishmania major	heat shock protein 83-1	0.0032	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0045	0.0045

Activities

Activity type	Activity value	Assay description	Source	Reference
CD50 (functional)	= 53 mg kg-1	Trypanocidal Activity at I.C.E. value 0.17 when administered subcutaneously.	ChEMBL.	2296025
CD50 (functional)	= 53 mg kg-1	Trypanocidal Activity at I.C.E. value 0.17 when administered subcutaneously.	ChEMBL.	2296025

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 173738