Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Yersinia pestis | Threonine--tRNA ligase | Starlite/ChEMBL | References |
Homo sapiens | threonyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Threonine--tRNA ligase | 642 aa | 630 aa | 39.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0059 | 0.8494 | 0.5 |
Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 1 |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0067 | 1 | 1 |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0059 | 0.8494 | 1 |
Chlamydia trachomatis | threonine--tRNA ligase | 0.0067 | 1 | 1 |
Plasmodium vivax | threonine--tRNA ligase, putative | 0.0059 | 0.8494 | 1 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 1 |
Leishmania major | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 1 |
Schistosoma mansoni | threonyl-tRNA synthetase | 0.0053 | 0.7416 | 1 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0059 | 0.8494 | 1 |
Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0059 | 0.8494 | 1 |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0059 | 0.8494 | 1 |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0067 | 1 | 1 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0059 | 0.8494 | 1 |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0067 | 1 | 1 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0059 | 0.8494 | 1 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 1 |
Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0059 | 0.8494 | 1 |
Plasmodium falciparum | threonine--tRNA ligase | 0.0059 | 0.8494 | 1 |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0059 | 0.8494 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 8.2 nM | Binding affinity to Yersinia pestis ThrRS by coupled spectrophotometry | ChEMBL. | 23362938 |
Ki (binding) | = 10.1 nM | Binding affinity to human cytoplasmic ThrRS by coupled spectrophotometry | ChEMBL. | 23362938 |
MIC (functional) | = 64 ug ml-1 | Antimicrobial activity against Escherichia coli BW25113 expressing TolC Leu13-Ala480 deletion mutant measured after overnight incubation by alamarBlue assay | ChEMBL. | 23362938 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.