Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | threonyl-tRNA synthetase | Starlite/ChEMBL | References |
Yersinia pestis | Threonine--tRNA ligase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Threonine--tRNA ligase | 642 aa | 630 aa | 39.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Chlamydia trachomatis | threonine--tRNA ligase | 0.0067 | 1 | 0.5 |
Plasmodium falciparum | threonine--tRNA ligase | 0.0059 | 0.8372 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0018 | 0 | 0.5 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0059 | 0.8372 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0059 | 0.8372 | 0.5 |
Schistosoma mansoni | threonyl-tRNA synthetase | 0.0053 | 0.7207 | 1 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Leishmania major | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0059 | 0.8372 | 0.5 |
Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 0.5 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0059 | 0.8372 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0059 | 0.8372 | 0.5 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0059 | 0.8372 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0059 | 0.8372 | 0.5 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0067 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0059 | 0.8372 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0059 | 0.8372 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Plasmodium vivax | threonine--tRNA ligase, putative | 0.0059 | 0.8372 | 0.5 |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | 0.0018 | 0 | 0.5 | |
Onchocerca volvulus | 0.0018 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.