Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0061 | 0.3573 | 0.3573 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0017 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | nardilysin | 0.0029 | 0.0984 | 0.0929 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.014 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0061 | 0.3573 | 0.2882 |
Brugia malayi | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.3619 | 0.3619 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.3619 | 0.358 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0.3573 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.3619 | 0.3619 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0061 | 0.3573 | 0.2882 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0061 | 0.3573 | 0.3573 |
Onchocerca volvulus | 0.0029 | 0.097 | 0.2716 | |
Brugia malayi | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | DR-78 | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0032 | 0.1249 | 0.1249 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.1249 | 0.1249 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0029 | 0.097 | 0.2716 |
Brugia malayi | nuclear receptor RXR | 0.0029 | 0.097 | 0.097 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0029 | 0.097 | 0.2716 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Toxoplasma gondii | rhoptry metalloprotease toxolysin TLN1 | 0.0029 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0061 | 0.3573 | 0.2882 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.1249 | 0.0309 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0061 | 0.3573 | 0.3533 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.014 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0061 | 0.3573 | 0.2882 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Brugia malayi | nuclear receptor NHR-88 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0029 | 0.097 | 0.0915 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.014 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0029 | 0.0984 | 0.0016 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.3619 | 0.2934 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0061 | 0.3573 | 1 |
Toxoplasma gondii | sporozoite developmental protein | 0.0029 | 0.0984 | 0.0984 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0029 | 0.097 | 0.097 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Echinococcus multilocularis | nardilysin | 0.0029 | 0.0984 | 0.0929 |
Echinococcus multilocularis | insulin degrading enzyme | 0.0029 | 0.0984 | 0.0929 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0061 | 0.3573 | 0.3533 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Trypanosoma cruzi | peptidase, putative | 0.0029 | 0.0984 | 0.0984 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | conserved hypotetical protein | 0.0029 | 0.097 | 0.097 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0029 | 0.097 | 0.0915 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0061 | 0.3573 | 0.2882 |
Trypanosoma brucei | peptidase, putative | 0.0029 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0029 | 0.097 | 0.0915 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0029 | 0.097 | 0.097 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.014 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.3619 | 0.3619 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0029 | 0.097 | 0.097 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0.3573 | 0.3533 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.3619 | 0.3619 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.014 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0.3573 | 1 | |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.3619 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Brugia malayi | tailless protein | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Chlamydia trachomatis | insulinase family protease III | 0.0029 | 0.0984 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0032 | 0.1249 | 0.1249 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0029 | 0.097 | 0.097 |
Echinococcus granulosus | FTZ F1 alpha | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0061 | 0.3573 | 0.2882 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0032 | 0.1249 | 0.1195 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.097 | 0.0915 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | 3'partial|nardilysin | 0.0029 | 0.0984 | 0.0984 |
Brugia malayi | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0029 | 0.0984 | 0.0016 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0061 | 0.3573 | 0.3533 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0029 | 0.0984 | 0.0016 |
Leishmania major | eukaryotic translation initiation factor-like | 0.014 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0029 | 0.097 | 0.0915 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0061 | 0.3573 | 0.2882 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | nuclear hormone receptor | 0.0061 | 0.3573 | 0.2882 |
Brugia malayi | nuclear receptor RXR | 0.0032 | 0.1249 | 0.1249 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3619 | 0.3619 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0061 | 0.3573 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | nuclear hormone receptor | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0061 | 0.3573 | 0.3573 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0061 | 0.3573 | 0.2882 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0061 | 0.3573 | 0.3573 |
Plasmodium vivax | hypothetical protein, conserved | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | nardilysin | 0.0029 | 0.0984 | 0.0984 |
Brugia malayi | ecdysteroid receptor | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0061 | 0.3573 | 0.3573 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.097 | 0.097 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | nuclear receptor NHR-67 | 0.0029 | 0.097 | 0.097 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0032 | 0.1249 | 0.0309 |
Echinococcus granulosus | insulin degrading enzyme | 0.0029 | 0.0984 | 0.0984 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0029 | 0.0984 | 0.0016 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0061 | 0.3573 | 0.3573 |
Leishmania major | phosphoglycan beta 1,3 galactosyltransferase 5 | 0.0029 | 0.0984 | 0.0984 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.3619 | 0.3619 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0061 | 0.3573 | 1 |
Brugia malayi | steroid hormone receptor | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | insulin-degrading enzyme | 0.0029 | 0.0984 | 0.0984 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0061 | 0.3573 | 0.2882 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0029 | 0.097 | 0.097 |
Trypanosoma cruzi | peptidase, putative | 0.0029 | 0.0984 | 0.0984 |
Schistosoma mansoni | thyroid hormone receptor | 0.0061 | 0.3573 | 0.2882 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0061 | 0.3573 | 0.3533 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0061 | 0.3573 | 0.3573 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.014 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0029 | 0.097 | 0.097 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0061 | 0.3573 | 0.2882 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.014 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0029 | 0.097 | 0.097 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0029 | 0.097 | 0.097 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0029 | 0.097 | 0.097 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.097 | 0.097 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0061 | 0.3573 | 0.3533 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0061 | 0.3573 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Toxoplasma gondii | insulysin, putative | 0.0028 | 0.087 | 0.087 |
Toxoplasma gondii | peptidase M16 inactive domain-containing protein | 0.0018 | 0.0061 | 0.0061 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3619 | 0.3619 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.3619 | 0.358 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0029 | 0.097 | 0.097 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | insulin-degrading enzyme | 0.0029 | 0.0984 | 0.0984 |
Schistosoma mansoni | thyroid hormone receptor | 0.0061 | 0.3573 | 0.2882 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0029 | 0.097 | 0.0915 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0061 | 0.3573 | 0.3573 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3619 | 0.3619 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.3619 | 0.3619 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0061 | 0.3573 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.3619 | 0.3619 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.014 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Onchocerca volvulus | 0.0029 | 0.097 | 0.2716 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log (functional) | = 1.4 % | Compound was tested for % Protection of ATH8 cells from HIV infection by 2 pM concentration of nucleoside | ChEMBL. | No reference |
logP | = 0.35 | Dissociation constant | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.