Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ecdysone receptor | 0.0029 | 0.097 | 0.097 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.014 | 1 | 1 |
Trypanosoma cruzi | peptidase, putative | 0.0029 | 0.0984 | 0.0984 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0029 | 0.097 | 0.097 |
Brugia malayi | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.014 | 1 | 1 |
Echinococcus multilocularis | nardilysin | 0.0029 | 0.0984 | 0.0929 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0029 | 0.097 | 0.097 |
Chlamydia trachomatis | insulinase family protease III | 0.0029 | 0.0984 | 0.5 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0029 | 0.097 | 0.097 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0029 | 0.097 | 0.2716 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.014 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0061 | 0.3573 | 0.3533 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0029 | 0.097 | 0.097 |
Toxoplasma gondii | insulysin, putative | 0.0028 | 0.087 | 0.087 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0032 | 0.1249 | 0.0309 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0061 | 0.3573 | 0.3573 |
Leishmania major | eukaryotic translation initiation factor-like | 0.014 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0032 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | DR-78 | 0.0029 | 0.097 | 0.097 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0029 | 0.097 | 0.097 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.3619 | 0.2934 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.014 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0029 | 0.097 | 0.097 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0029 | 0.097 | 0.0915 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0029 | 0.097 | 0.097 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0029 | 0.0984 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0061 | 0.3573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | nuclear receptor RXR | 0.0029 | 0.097 | 0.097 |
Brugia malayi | steroid hormone receptor | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Onchocerca volvulus | 0.0029 | 0.097 | 0.2716 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.1249 | 0.1249 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.3619 | 0.358 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0029 | 0.097 | 0.0915 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0029 | 0.097 | 0.0915 |
Brugia malayi | tailless protein | 0.0029 | 0.097 | 0.097 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | nardilysin | 0.0029 | 0.0984 | 0.0984 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0029 | 0.097 | 0.0915 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | insulin degrading enzyme | 0.0029 | 0.0984 | 0.0984 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0061 | 0.3573 | 0.2882 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.3619 | 0.3619 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0061 | 0.3573 | 0.3533 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0032 | 0.1249 | 0.1195 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0029 | 0.097 | 0.2716 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0029 | 0.097 | 0.0915 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.3619 | 0.3619 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0061 | 0.3573 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | insulin-degrading enzyme | 0.0029 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0061 | 0.3573 | 0.2882 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0029 | 0.097 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0061 | 0.3573 | 0.2882 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0029 | 0.097 | 0.0915 |
Echinococcus multilocularis | nardilysin | 0.0029 | 0.0984 | 0.0929 |
Brugia malayi | nuclear receptor NHR-67 | 0.0029 | 0.097 | 0.097 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0061 | 0.3573 | 0.2882 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Echinococcus multilocularis | insulin degrading enzyme | 0.0029 | 0.0984 | 0.0929 |
Echinococcus granulosus | 3'partial|nardilysin | 0.0029 | 0.0984 | 0.0984 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.014 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0061 | 0.3573 | 0.2882 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0061 | 0.3573 | 0.3573 |
Leishmania major | phosphoglycan beta 1,3 galactosyltransferase 5 | 0.0029 | 0.0984 | 0.0984 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0061 | 0.3573 | 1 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0029 | 0.0984 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0061 | 0.3573 | 0.3533 |
Schistosoma mansoni | insulysin unit 3 (M16 family) | 0.0029 | 0.0984 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0061 | 0.3573 | 0.3573 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.3619 | 1 |
Onchocerca volvulus | 0.0061 | 0.3573 | 1 | |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.014 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0029 | 0.097 | 0.097 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0061 | 0.3573 | 0.3533 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0061 | 0.3573 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | nuclear receptor RXR | 0.0032 | 0.1249 | 0.1249 |
Brugia malayi | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Toxoplasma gondii | peptidase M16 inactive domain-containing protein | 0.0018 | 0.0061 | 0.0061 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.014 | 1 | 1 |
Schistosoma mansoni | nardilysin (M16 family) | 0.0029 | 0.0984 | 0.0016 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0061 | 0.3573 | 0.3573 |
Trypanosoma brucei | peptidase, putative | 0.0029 | 0.0984 | 0.0984 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0061 | 0.3573 | 0.3573 |
Plasmodium vivax | hypothetical protein, conserved | 0.0017 | 0 | 0.5 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0029 | 0.097 | 0.097 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0032 | 0.1249 | 0.1249 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0061 | 0.3573 | 0.3573 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.014 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0061 | 0.3573 | 0.2882 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | FTZ F1 alpha | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.1249 | 0.0309 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0061 | 0.3573 | 0.2882 |
Trypanosoma cruzi | peptidase, putative | 0.0029 | 0.0984 | 0.0984 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0.3573 | 0.3533 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.3619 | 0.3619 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.3619 | 0.3619 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0029 | 0.097 | 0.097 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0061 | 0.3573 | 0.3573 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | thyroid hormone receptor | 0.0061 | 0.3573 | 0.2882 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0061 | 0.3573 | 0.2882 |
Toxoplasma gondii | sporozoite developmental protein | 0.0029 | 0.0984 | 0.0984 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0061 | 0.3573 | 0.2882 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0061 | 0.3573 | 0.3533 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.014 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3619 | 0.3619 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0029 | 0.097 | 0.097 |
Brugia malayi | nuclear hormone receptor | 0.0061 | 0.3573 | 0.3573 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.014 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 0.097 | 0.2716 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0029 | 0.097 | 0.097 |
Toxoplasma gondii | rhoptry metalloprotease toxolysin TLN1 | 0.0029 | 0.0984 | 0.0984 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3619 | 0.3619 |
Brugia malayi | nuclear receptor NHR-88 | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0061 | 0.3573 | 0.3533 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0017 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0061 | 0.3573 | 0.2882 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.3619 | 0.358 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.014 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0061 | 0.3573 | 0.2882 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.3573 | 0.3573 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0061 | 0.3573 | 0.3533 |
Brugia malayi | conserved hypotetical protein | 0.0029 | 0.097 | 0.097 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0061 | 0.3573 | 0.3573 |
Brugia malayi | nuclear hormone receptor | 0.0029 | 0.097 | 0.097 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0061 | 0.3573 | 0.3573 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0061 | 0.3573 | 0.2882 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0029 | 0.097 | 0.097 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0061 | 0.3573 | 0.3573 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0017 | 0 | 0.5 |
Brugia malayi | insulin-degrading enzyme | 0.0029 | 0.0984 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1249 | 0.1249 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0061 | 0.3573 | 0.3573 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log (functional) | = 1.4 % | Compound was tested for % Protection of ATH8 cells from HIV infection by 2 pM concentration of nucleoside | ChEMBL. | No reference |
logP | = 0.35 | Dissociation constant | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.