Detailed information for compound 1740326

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1607.75 | Formula: C69H77F3N14O18S5
  • H donors: 10 H acceptors: 18 LogP: 3.83 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(=O)C(F)(F)F.CO/C(=C\1/NC(=O)[C@@H](NC(=O)c2csc(n2)c2cc(O)c(nc2c2csc(n2)[C@H]2NC(=O)c3nc([C@@H](NC(=O)c4nc1sc4)[C@@H]1OCc4c5c(COC(=O)[C@H]1O[C@@H]1O[C@@H](C)[C@H]([C@@](C1)(C)O)N(C)C)cccc5n(c4C(=O)OC2)O)sc3)c1scc(n1)CNCC(N1CCCCC1)(C)C)[C@H](O)C)/C
  • InChi: 1S/C67H76N14O16S5.C2HF3O2/c1-30(82)46-58(87)77-47(31(2)92-9)61-73-41(28-101-61)57(86)78-50-52-53(97-44-19-67(6,90)54(79(7)8)32(3)96-44)65(89)94-21-33-14-13-15-42-45(33)36(22-93-52)51(81(42)91)64(88)95-23-37(70-55(84)39-27-102-63(50)74-39)60-71-38(25-100-60)48-35(59-72-40(26-99-59)56(85)76-46)18-43(83)49(75-48)62-69-34(24-98-62)20-68-29-66(4,5)80-16-11-10-12-17-80;3-2(4,5)1(6)7/h13-15,18,24-28,30,32,37,44,46,50,52-54,68,82-83,90-91H,10-12,16-17,19-23,29H2,1-9H3,(H,70,84)(H,76,85)(H,77,87)(H,78,86);(H,6,7)/b47-31+;/t30-,32+,37+,44+,46+,50+,52+,53+,54-,67+;/m1./s1
  • InChiKey: NNXRWZLLZOZILS-ODKRUETDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0064 0.0064
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0393 0.0393
Schistosoma mansoni hypothetical protein 0.0166 0.1949 0.2121
Trypanosoma brucei unspecified product 0.0019 0.0064 0.0135
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0229 0.0615
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0064 0.0173
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0304 0.3722 1
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0159 0.1857 0.202
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0114 0.1282 0.342
Echinococcus granulosus microtubule associated protein 2 0.0732 0.9191 1
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0304 0.3722 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0014 0.0014
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0393 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Schistosoma mansoni alkaline phosphatase 0.0159 0.1857 0.202
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0061 0.0165
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0159 0.1857 0.202
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1106 0.2973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.031 0.0833
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0443 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Loa Loa (eye worm) hypothetical protein 0.0304 0.3722 1
Echinococcus multilocularis ETHE1 protein 0.0304 0.3722 0.3722
Mycobacterium tuberculosis Conserved hypothetical protein 0.0304 0.3722 1
Mycobacterium tuberculosis Conserved protein 0.0304 0.3722 1
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1106 0.2973
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0304 0.3722 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0064 0.0173
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2244 0.6031
Onchocerca volvulus 0.0304 0.3722 1
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0159 0.1857 0.1857
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0061 0.0165
Entamoeba histolytica hypothetical protein 0.0038 0.0311 0.0835
Schistosoma mansoni hypothetical protein 0.0304 0.3722 0.4049
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1311 0.3522
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0304 0.3722 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Schistosoma mansoni zinc phosphodiesterase 0.0304 0.3722 0.4049
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0304 0.3722 1
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0159 0.1857 0.1857
Echinococcus multilocularis microtubule associated protein 2 0.0732 0.9191 0.9191
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0114 0.1282 0.1395
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0276 0.0301
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0067
Echinococcus multilocularis alkaline phosphatase 0.0159 0.1857 0.1857
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0304 0.3722 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0277 0.0709
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1282 0.3445
Onchocerca volvulus Putative hydrolase PNKD 0.0304 0.3722 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1282 0.342
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1282 0.1282
Trichomonas vaginalis A-type flavoprotein 0.0304 0.3722 1
Brugia malayi MH2 domain containing protein 0.0116 0.1311 0.3522
Loa Loa (eye worm) hypothetical protein 0.0304 0.3722 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0064 0.0064
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0393 0.1023
Echinococcus multilocularis zinc phosphodiesterase 0.0304 0.3722 0.3722
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0304 0.3722 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0064 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0114 0.1282 0.342
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0064 0.0135
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0393 0.1057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0195 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Loa Loa (eye worm) hypothetical protein 0.0304 0.3722 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0451 0.0491
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0276 0.0743
Echinococcus granulosus ETHE1 protein 0.0304 0.3722 0.4049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Entamoeba histolytica hypothetical protein 0.0038 0.0311 0.0835
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0135
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0304 0.3722 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0276 0.0708
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0064 0.007
Giardia lamblia DINP protein human, muc B family 0.0019 0.0064 0.0008
Mycobacterium tuberculosis Possible hydrolase 0.0304 0.3722 1
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0276 0.0743
Schistosoma mansoni hypothetical protein 0.0304 0.3722 0.4049
Mycobacterium ulcerans beta lactamase-like protein 0.0304 0.3722 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0114 0.1282 0.1395
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0014 0.0015
Entamoeba histolytica metallo-beta-lactamase family protein 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0304 0.3722 0.3722
Mycobacterium ulcerans hydrolase 0.0304 0.3722 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0064 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0173
Loa Loa (eye worm) hypothetical protein 0.0304 0.3722 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0276 0.0588
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0393 0.1057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0229 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0393 0.0428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0164 0.044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Entamoeba histolytica alkyl sulfatase, putative 0.0304 0.3722 1
Echinococcus granulosus tumor protein p63 0.0335 0.4116 0.4479
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1868 0.1868
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0393 0.1023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0061 0.0165
Entamoeba histolytica alkyl sulfatase, putative 0.0304 0.3722 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Echinococcus granulosus intestinal type alkaline phosphatase 0.0159 0.1857 0.202
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1118 0.3005
Schistosoma mansoni hypothetical protein 0.0069 0.07 0.0762
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0229 0.0249
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1868 0.2032
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1282 0.1282
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0443 0.1191
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0114 0.1282 0.3335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0131 0.0351
Loa Loa (eye worm) isocitrate dehydrogenase 0.0114 0.1282 0.3445
Schistosoma mansoni alkaline phosphatase 0.0159 0.1857 0.202
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0195 0.0212
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Brugia malayi HSF-type DNA-binding domain containing protein 0.0101 0.1118 0.3005
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0249
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0443 0.1191
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0276 0.0743
Schistosoma mansoni hypothetical protein 0.0304 0.3722 0.4049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.013 0.035
Brugia malayi metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0064 0.0173
Trypanosoma cruzi glyoxalase II 0.0304 0.3722 1
Entamoeba histolytica hypothetical protein 0.0038 0.0311 0.0835
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0304 0.3722 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0277 0.0709
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0061 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0195 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0114 0.1282 0.3445
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1311 0.3522
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0064 0.0173
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0276 0.0743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Loa Loa (eye worm) hypothetical protein 0.0069 0.07 0.1882
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0304 0.3722 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0064 0.007
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0093 0.0212
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1282 0.342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Brugia malayi hypothetical protein 0.0038 0.0311 0.0835
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0524
Trypanosoma brucei glucosidase, putative 0.0035 0.0276 0.0708
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0229 0.0615
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2417 0.6494
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0014 0.0038
Leishmania major hypothetical protein, conserved 0.0304 0.3722 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Schistosoma mansoni alpha-glucosidase 0.0137 0.1583 0.1722
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0135
Loa Loa (eye worm) hypothetical protein 0.0049 0.0451 0.1212
Schistosoma mansoni zinc phosphodiesterase 0.0304 0.3722 0.4049
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Echinococcus multilocularis tumor protein p63 0.0335 0.4116 0.4116
Mycobacterium ulcerans hypothetical protein 0.0304 0.3722 1
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1118 0.3005
Plasmodium vivax SET domain protein, putative 0.0029 0.0195 0.0365
Schistosoma mansoni microtubule-associated protein tau 0.0732 0.9191 1
Mycobacterium leprae Beta-lactamase-like protein 0.0304 0.3722 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0061 0.0067
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1868 0.5018
Echinococcus granulosus GPCR family 2 0.0032 0.0229 0.0249
Entamoeba histolytica type A flavoprotein, putative 0.0304 0.3722 1
Loa Loa (eye worm) hypothetical protein 0.015 0.1739 0.4673
Trypanosoma cruzi glyoxalase II 0.0304 0.3722 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0247 0.0508
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0393 0.1057
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0164 0.044
Schistosoma mansoni alpha-glucosidase 0.0137 0.1583 0.1722
Echinococcus multilocularis geminin 0.0166 0.1949 0.1949
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Chlamydia trachomatis ribonuclease Z 0.0304 0.3722 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0064 0.0173
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0273 0.3325 0.8934
Giardia lamblia GTOR 0.0045 0.0393 0.0907
Onchocerca volvulus 0.015 0.1739 0.4379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0195 0.0212
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0273 0.3325 0.8934
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Entamoeba histolytica hypothetical protein, conserved 0.0304 0.3722 1
Mycobacterium leprae conserved hypothetical protein 0.0304 0.3722 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0276 0.0743
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0276 0.0743
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0064 0.0173
Onchocerca volvulus 0.0092 0.1005 0.2298
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0393 0.1057
Mycobacterium leprae POSSIBLE HYDROLASE 0.0304 0.3722 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0276 0.0743
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0061 0.0127
Mycobacterium tuberculosis Conserved protein 0.0304 0.3722 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0393 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.013 0.035
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.006 0.0123
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0304 0.3722 0.3722
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0304 0.3722 0.4049
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0064 0.007
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0276 0.0708
Echinococcus multilocularis dna polymerase eta 0.0019 0.0064 0.0064
Brugia malayi Isocitrate dehydrogenase 0.0114 0.1282 0.3445
Onchocerca volvulus 0.0049 0.0451 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0393 0.1057
Leishmania major DNA polymerase kappa, putative 0.0019 0.0064 0.0173
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0393 0.1057
Mycobacterium leprae conserved hypothetical protein 0.0304 0.3722 1
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0304 0.3722 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0064 0.0173
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0014 0.0015
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0304 0.3722 1
Mycobacterium tuberculosis Possible hydrolase 0.0304 0.3722 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0443 0.0443
Entamoeba histolytica hypothetical protein 0.0038 0.0311 0.0835
Schistosoma mansoni hypothetical protein 0.0038 0.0311 0.0338
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0064 0.0173
Mycobacterium ulcerans hydrolase 0.0304 0.3722 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0443 0.0482
Schistosoma mansoni alpha glucosidase 0.0035 0.0276 0.0301
Schistosoma mansoni hypothetical protein 0.0166 0.1949 0.2121
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0195 0.0212
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0443 0.0482
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0195 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0229 0.0615
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0159 0.1857 0.1857
Brugia malayi Pre-SET motif family protein 0.0029 0.0195 0.0524
Echinococcus multilocularis isocitrate dehydrogenase 0.0114 0.1282 0.1282
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1106 0.2973
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0443 0.0443
Echinococcus granulosus geminin 0.0166 0.1949 0.2121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.0127
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0064 0.0173
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Echinococcus granulosus alkaline phosphatase 0.0159 0.1857 0.202
Leishmania major metallo-beta-lactamase family-like protein 0.0304 0.3722 1
Loa Loa (eye worm) hypothetical protein 0.01 0.1106 0.2973
Toxoplasma gondii isocitrate dehydrogenase 0.0114 0.1282 0.3335
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0061 0.0061
Trypanosoma cruzi glyoxalase II 0.0304 0.3722 1
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0393 0.1057
Treponema pallidum ribonuclease Z 0.0304 0.3722 1
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0164 0.044
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0114 0.1282 0.1282
Brugia malayi ethe1-prov protein 0.0304 0.3722 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0249
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0229 0.0229
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0064 0.0173
Schistosoma mansoni hypothetical protein 0.0083 0.088 0.0957
Entamoeba histolytica metallo-beta-lactamase family protein 0.0304 0.3722 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0195 0.0212
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1118 0.3005
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0061 0.0165
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0064 0.0173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0443 0.0482
Loa Loa (eye worm) hypothetical protein 0.0032 0.0229 0.0615
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0304 0.3722 1
Brugia malayi hypothetical protein 0.0304 0.3722 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0304 0.3722 0.3722
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2775 0.7457
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0443 0.0482
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0304 0.3722 1
Mycobacterium tuberculosis Beta lactamase like protein 0.0304 0.3722 1
Trypanosoma brucei glyoxalase II 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.016 0.0431
Onchocerca volvulus 0.0231 0.2775 0.7316
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0131 0.0351
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1118 0.3005
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0064 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.013 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0131 0.0351
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0064 0.0173
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0165
Trichomonas vaginalis apoptosis inducing factor, putative 0.0304 0.3722 1
Entamoeba histolytica type A flavoprotein, putative 0.0304 0.3722 1
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0304 0.3722 1
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0304 0.3722 1
Echinococcus granulosus zinc phosphodiesterase 0.0304 0.3722 0.4049
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0014 0.0038
Plasmodium vivax unspecified product 0.0304 0.3722 1
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0067
Brugia malayi hypothetical protein 0.015 0.1739 0.4673
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Brugia malayi isocitrate dehydrogenase 0.0114 0.1282 0.3445
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0276 0.0743
Mycobacterium tuberculosis Conserved hypothetical protein 0.0304 0.3722 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Brugia malayi metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0229 0.0229
Brugia malayi Pre-SET motif family protein 0.0203 0.2417 0.6494
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0304 0.3722 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0195 0.0195
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0393 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.016 0.0431
Mycobacterium ulcerans hypothetical protein 0.0304 0.3722 1
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.2121 0.5461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Mycobacterium ulcerans hydrolase 0.0304 0.3722 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1282 0.1282
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2244 0.6031
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0304 0.3722 0.4049
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0304 0.3722 1
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0304 0.3722 0.4049
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0114 0.1282 0.3335
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0304 0.3722 0.4049
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0277 0.0744
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0205 0.0552
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0304 0.3722 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0014 0.0038
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0101 0.1118 0.2619
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0276 0.0743
Toxoplasma gondii isocitrate dehydrogenase 0.0114 0.1282 0.3335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Mycobacterium tuberculosis Conserved hypothetical protein 0.0304 0.3722 1
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Entamoeba histolytica metallo-beta-lactamase family protein 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0393 0.1057
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0311 0.0338
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0311 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0193 0.0519
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0311 0.0338
Schistosoma mansoni DNA polymerase eta 0.0019 0.0064 0.007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0181 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0014 0.0038
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0393 0.1057
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1868 0.1868
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0061 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0131 0.0351
Onchocerca volvulus 0.0304 0.3722 1
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.07 0.1882
Plasmodium falciparum cytosolic glyoxalase II 0.0304 0.3722 1
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1868 0.5018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0229 0.0249
Mycobacterium ulcerans hypothetical protein 0.0304 0.3722 1
Mycobacterium ulcerans glyoxalase II, GloB 0.0304 0.3722 1
Mycobacterium ulcerans hypothetical protein 0.0304 0.3722 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0249
Leishmania major metallo-beta-lactamase family protein-like protein 0.0304 0.3722 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0061 0.0165
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0276 0.0276
Mycobacterium tuberculosis Conserved protein 0.0304 0.3722 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0304 0.3722 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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