TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 534.524 | Formula: C26H37Cl2N7O
H donors: 3 H acceptors: 3 LogP: 5.38 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CN1CCC(CC1)NC(=O)c1cnc(nc1NC1CCC(CC1)N(C)C)NCc1cc(Cl)ccc1Cl
InChi: 1S/C26H37Cl2N7O/c1-34(2)21-7-5-19(6-8-21)31-24-22(25(36)32-20-10-12-35(3)13-11-20)16-30-26(33-24)29-15-17-14-18(27)4-9-23(17)28/h4,9,14,16,19-21H,5-8,10-13,15H2,1-3H3,(H,32,36)(H2,29,30,31,33)
InChiKey: LQMDBOVNAUGROB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TYRO3 protein tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	selectin P (granule membrane protein 140kDa, antigen CD62)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_132328	All targets in OG5_132328

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	C type lectin domian containing protein	0.0019	0.0059	0.0213
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0127	0.0489
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0215	1
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0143	0.0537
Onchocerca volvulus		0.0019	0.0059	0.0077
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.067	0.5887	0.879
Brugia malayi	Importin beta-1 subunit	0.0028	0.0143	0.0873
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0215	0.0813
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0215	0.0992
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0215	0.0769
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.0175	0.1459	0.1302
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0076	0.0121
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0063	0.045	0.0274
Schistosoma mansoni	ran	0.0021	0.0076	0.0233
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0143	0.0537
Mycobacterium tuberculosis	Probable esterase LipL	0.0177	0.1472	0.1316
Onchocerca volvulus		0.0019	0.0059	0.0077
Schistosoma mansoni	importin beta-1	0.0028	0.0143	0.0493
Schistosoma mansoni	ran	0.0021	0.0076	0.0233
Brugia malayi	beta-lactamase	0.0177	0.1472	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0229
Trichomonas vaginalis	penicillin-binding protein, putative	0.0177	0.1472	0.2237
Echinococcus granulosus	snurportin 1	0.0302	0.2596	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0215	0.077
Brugia malayi	hypothetical protein	0.0019	0.0059	0.0296
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0016	0.0063
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0177	0.1472	0.1949
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.0439	0.3818	0.3704
Mycobacterium leprae	Probable penicillin-binding membrane protein PbpB	0.0224	0.1892	0.2789
Chlamydia trachomatis	transglycolase/transpeptidase	0.0672	0.5907	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0215	0.0221
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0076	0.0278
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0215	0.1098
Brugia malayi	hypothetical protein	0.0019	0.0059	0.0296
Mycobacterium leprae	Probable lipase LipE	0.0177	0.1472	0.2106
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0215	0.0992
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.0439	0.3818	0.5929
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0017	0.0004
Echinococcus granulosus	C type lectin domian containing protein	0.0019	0.0059	0.0213
Echinococcus granulosus	c4b binding protein beta chain	0.0019	0.0059	0.0213
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0095	0.003
Brugia malayi	beta-lactamase family protein	0.0177	0.1472	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0177	0.1472	0.1949
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0177	0.1472	1
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.013	0.1056	0.1305
Echinococcus granulosus	beta LACTamase domain containing family member	0.0177	0.1472	0.5665
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0229
Schistosoma mansoni	hypothetical protein	0.0166	0.1379	0.5285
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0302	0.2596	1
Echinococcus multilocularis	lamin	0.0026	0.0127	0.0473
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1472	0.2237
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0177	0.1472	0.5645
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0215	0.0992
Mycobacterium tuberculosis	Probable hydrolase	0.0177	0.1472	0.1316
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0215	0.099
Brugia malayi	hypothetical protein	0.0019	0.0059	0.0296
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1472	0.2237
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0017	0.0065
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0215	0.0222
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0016	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1472	0.5672
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.0537	0.2056
Mycobacterium tuberculosis	Probable penicillin-binding membrane protein PbpB	0.0224	0.1892	0.1743
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0123	0.0473
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0215	0.0811
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0215	0.077
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1472	0.5672
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0143	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0004	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0229
Echinococcus granulosus	lamin	0.0026	0.0127	0.0473
Toxoplasma gondii	ABC1 family protein	0.0177	0.1472	1
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0215	0.0813
Onchocerca volvulus		0.0177	0.1472	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0143	0.0552
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0076	0.0278
Schistosoma mansoni	lamin	0.0026	0.0127	0.0429
Brugia malayi	intermediate filament protein	0.0026	0.0127	0.076
Onchocerca volvulus		0.0177	0.1472	1
Echinococcus granulosus	lamin dm0	0.0026	0.0127	0.0473
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0215	0.0813
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0215	0.099
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0076	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0229
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0215	0.0992
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.0672	0.5907	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0177	0.1472	0.2237
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0177	0.1472	0.5665
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0215	0.0222
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.0718	0.6316	1
Brugia malayi	pregnancy-associated plasma protein-A	0.0019	0.0059	0.0296
Mycobacterium ulcerans	lipoprotein LpqF	0.0063	0.045	0.0365
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0215	0.0813
Mycobacterium ulcerans	multidrugs-transport integral membrane protein Mmr-like	0.0757	0.6668	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0177	0.1472	0.5672
Echinococcus multilocularis	musashi	0.0026	0.0127	0.0473
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0215	0.0813
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0076	0.0121
Mycobacterium ulcerans	multidrug-transport integral membrane protein Mmr	0.0191	0.1597	0.2142
Brugia malayi	hypothetical protein	0.0019	0.0059	0.0296
Onchocerca volvulus		0.0019	0.0059	0.0077
Mycobacterium ulcerans	hypothetical protein	0.0177	0.1472	0.1949
Echinococcus multilocularis	lamin dm0	0.0026	0.0127	0.0473
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0215	0.099
Mycobacterium tuberculosis	Conserved protein	0.0177	0.1472	0.1316
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0215	0.0769
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0078	0.0302
Loa Loa (eye worm)	inositol-1	0.0036	0.0215	0.0827
Onchocerca volvulus		0.0019	0.0059	0.0077
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.0439	0.3818	0.5583
Echinococcus multilocularis	snurportin 1	0.0302	0.2596	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1472	0.5672
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0127	0.0429
Trichomonas vaginalis	conserved hypothetical protein	0.0718	0.6316	1
Echinococcus multilocularis	c4b binding protein beta chain	0.0019	0.0059	0.0213
Echinococcus granulosus	death domain containing protein	0.0014	0.0016	0.0046
Entamoeba histolytica	hypothetical protein	0.0023	0.0095	0.137
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0095	0.003
Schistosoma mansoni	c4b-binding protein beta chain	0.0019	0.0059	0.0167
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0016	0.0046
Mycobacterium tuberculosis	Conserved protein	0.0177	0.1472	0.1316
Brugia malayi	RNA, U transporter 1	0.0081	0.0611	0.4082
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1472	0.5672
Trypanosoma brucei	beta lactamase	0.0063	0.045	0.2675
Brugia malayi	Sushi domain	0.0019	0.0059	0.0296
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0019	0.0059	0.0229
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0177	0.1472	0.1316
Schistosoma mansoni	hypothetical protein	0.0302	0.2596	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0229
Mycobacterium ulcerans	lipase LipD	0.0177	0.1472	0.1949
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0017	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0127	0.0489
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0063	0.045	0.0439
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0143	0.0479
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0095	0.0136
Mycobacterium tuberculosis	Probable lipase LipD	0.0177	0.1472	0.1316
Echinococcus multilocularis	Ankyrin	0.0014	0.0017	0.005
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0095	0.003
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0215	0.0813
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0017	0.0067
Onchocerca volvulus		0.0026	0.0127	0.0552
Loa Loa (eye worm)	beta-lactamase	0.0177	0.1472	0.5672
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0215	0.0811
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0177	0.1472	0.5645
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0127	0.0489
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.0537	0.2056
Mycobacterium leprae	conserved hypothetical protein	0.0177	0.1472	0.2106
Echinococcus granulosus	Ankyrin	0.0014	0.0017	0.005
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0127	0.076
Toxoplasma gondii	rhoptry neck protein RON9	0.0019	0.0059	0.000000051859
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.0718	0.6316	0.9454
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0143	0.0594
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0016	0.0046
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0718	0.6316	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1472	0.5672
Echinococcus granulosus	intermediate filament protein	0.0026	0.0127	0.0473
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0016	0.0046
Trypanosoma cruzi	hypothetical protein, conserved	0.0177	0.1472	1
Brugia malayi	hypothetical protein	0.0019	0.0059	0.0296
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0076	0.0295
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0177	0.1472	0.1316
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0229
Brugia malayi	hypothetical protein	0.0019	0.0059	0.0296
Schistosoma mansoni	lamin	0.0026	0.0127	0.0429
Onchocerca volvulus		0.0019	0.0059	0.0077
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.0401	0.3481	0.5061
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0215	0.0222
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0215	0.1365
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1472	0.2237
Echinococcus multilocularis	geminin	0.0166	0.1379	0.5306
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0215	1
Trichomonas vaginalis	esterase, putative	0.0177	0.1472	0.2237
Plasmodium falciparum	importin beta, putative	0.0028	0.0143	1
Brugia malayi	Uncoordinated protein 44	0.0014	0.0016	0.000000050324
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1472	0.5672
Mycobacterium tuberculosis	Conserved protein	0.0177	0.1472	0.1316
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.013	0.1056	0.0892
Onchocerca volvulus		0.0177	0.1472	1
Leishmania major	hypothetical protein, conserved	0.0177	0.1472	1
Brugia malayi	hypothetical protein	0.0019	0.0059	0.0296
Schistosoma mansoni	hypothetical protein	0.0166	0.1379	0.5285
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0215	0.0828
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.0175	0.1459	0.2083
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.0401	0.3481	0.5379
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0016	0.000000050324
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0016	0.000000028407
Mycobacterium tuberculosis	Probable lipase LipE	0.0177	0.1472	0.1316
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0177	0.1472	0.1316
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0143	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0016	0.0063
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.0401	0.3481	0.3361
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0229
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0215	0.9972
Trypanosoma brucei	hypothetical protein, conserved	0.0177	0.1472	1
Brugia malayi	GCC2 and GCC3 family protein	0.0019	0.0059	0.0296
Brugia malayi	Death domain containing protein	0.0014	0.0016	0.000000050324
Plasmodium vivax	hypothetical protein, conserved	0.0177	0.1472	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0177	0.1472	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0215	0.0221
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0095	0.0136
Onchocerca volvulus		0.0019	0.0059	0.0077
Echinococcus granulosus	geminin	0.0166	0.1379	0.5306
Mycobacterium tuberculosis	Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase	0.0279	0.2388	0.2248
Onchocerca volvulus		0.0019	0.0059	0.0077
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0215	0.099
Onchocerca volvulus		0.0026	0.0127	0.0552
Mycobacterium ulcerans	beta-lactamase	0.0177	0.1472	0.1949
Onchocerca volvulus		0.0019	0.0059	0.0077
Brugia malayi	beta-lactamase family protein	0.0177	0.1472	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0076	0.0413
Treponema pallidum	penicillin-binding protein (pbp-1)	0.0672	0.5907	0.0472
Onchocerca volvulus		0.0019	0.0059	0.0077
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0215	0.0221
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.0175	0.1459	0.1928
Brugia malayi	Inositol-1	0.0036	0.0215	0.1362
Onchocerca volvulus		0.0019	0.0059	0.0077

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.041 uM	Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATP	ChEMBL.	23312943
IC50 (binding)	= 1.1 uM	Inhibition of P-selectin aggregation in platelet surface (unknown origin)	ChEMBL.	23312943
Inhibition (binding)	= 1.6 %	Displacement of [3H]dofetilide from human ERG at 10 uM	ChEMBL.	23312943

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2312648

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1740639