Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0368 | 1 | 1 |
Brugia malayi | brahma associated protein 60 kDa | 0.0368 | 1 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0368 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2515 | 0.2515 |
Plasmodium vivax | hypothetical protein, conserved | 0.0368 | 1 | 0.5 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0131 | 0.2515 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2515 | 0.2515 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0368 | 1 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0131 | 0.2515 | 0.2515 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0131 | 0.2515 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0131 | 0.2515 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0131 | 0.2515 | 0.2515 |
Schistosoma mansoni | hypothetical protein | 0.0131 | 0.2515 | 0.2515 |
Echinococcus multilocularis | tumor protein p63 | 0.035 | 0.9437 | 0.9248 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0131 | 0.2515 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Loa Loa (eye worm) | brahma associated protein | 0.0368 | 1 | 1 |
Onchocerca volvulus | 0.0131 | 0.2515 | 0.2515 | |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0131 | 0.2515 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0131 | 0.2515 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0368 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0368 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0368 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0368 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0368 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0368 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0368 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0131 | 0.2515 | 0.5 |
Onchocerca volvulus | 0.0131 | 0.2515 | 0.2515 | |
Onchocerca volvulus | 0.0368 | 1 | 1 | |
Schistosoma mansoni | fusion | 0.0131 | 0.2515 | 0.2515 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0368 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2515 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2515 | 0.2515 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0368 | 1 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0368 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0131 | 0.2515 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0368 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0368 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.2515 | 0.2515 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0131 | 0.2515 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.035 | 0.9437 | 0.9248 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0368 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 1 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0368 | 1 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0131 | 0.2515 | 0.2515 |
Leishmania major | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Onchocerca volvulus | 0.0131 | 0.2515 | 0.2515 | |
Onchocerca volvulus | 0.0131 | 0.2515 | 0.2515 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0131 | 0.2515 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0131 | 0.2515 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0368 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/D50 (functional) | < 3 | Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. | ChEMBL. | 7069706 |
Log 1/LD10 (ADMET) | < 3 | Compound concentration in mole/kg/day lethal to 10% of mice | ChEMBL. | 7069706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.