Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Yersinia pestis | Threonine--tRNA ligase | Starlite/ChEMBL | References |
Homo sapiens | threonyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Threonine--tRNA ligase | 642 aa | 630 aa | 39.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TKL/MLK/TAK1 protein kinase | 0.009 | 1 | 1 |
Echinococcus granulosus | 5'partial|3'partial|mitogen activated protein kinase kinase kinase | 0.0088 | 0.9722 | 0.9722 |
Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0059 | 0.5904 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.009 | 1 | 1 |
Chlamydia trachomatis | threonine--tRNA ligase | 0.0067 | 0.6951 | 1 |
Echinococcus granulosus | 3'partial|mitogen activated protein kinase kinase kinase | 0.0088 | 0.9722 | 0.9722 |
Echinococcus multilocularis | kinase protein | 0.0088 | 0.9722 | 0.9722 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0059 | 0.5904 | 1 |
Schistosoma mansoni | threonyl-tRNA synthetase | 0.0053 | 0.5155 | 1 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0059 | 0.5904 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0088 | 0.9722 | 0.9722 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0059 | 0.5904 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase 7 | 0.0088 | 0.9722 | 0.9722 |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0067 | 0.6951 | 0.6951 |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0067 | 0.6951 | 0.6951 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0067 | 0.6951 | 1 |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0059 | 0.5904 | 1 |
Brugia malayi | threonyl-tRNA synthetase, cytoplasmic | 0.0067 | 0.6951 | 0.6951 |
Plasmodium vivax | threonine--tRNA ligase, putative | 0.0059 | 0.5904 | 1 |
Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.0067 | 0.6951 | 1 |
Plasmodium falciparum | threonine--tRNA ligase | 0.0059 | 0.5904 | 1 |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0059 | 0.5904 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.009 | 1 | 1 |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0067 | 0.6951 | 0.6951 |
Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0059 | 0.5904 | 1 |
Echinococcus multilocularis | kinase protein | 0.0088 | 0.9722 | 0.9722 |
Leishmania major | threonyl-tRNA synthetase, putative | 0.0067 | 0.6951 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0088 | 0.9722 | 0.9722 |
Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0059 | 0.5904 | 1 |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0059 | 0.5904 | 1 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0067 | 0.6951 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0088 | 0.9722 | 0.9722 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.