Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0107 | 0.0874 | 0.2498 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.037 | 0.0427 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0286 | 0.2657 | 0.4393 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0041 | 0.0118 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0174 | 0.1544 | 0.1949 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0196 | 0.3753 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0107 | 0.0874 | 0.2498 |
Trichomonas vaginalis | set domain proteins, putative | 0.0237 | 0.2164 | 0.5595 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0113 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0041 | 0.0219 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.0186 | 0.0531 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0041 | 0.0219 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.037 | 0.0427 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0454 | 0.1297 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.0041 | 0.0118 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.08 | 0.7752 | 0.6355 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0113 | 0.0323 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0056 | 0.037 | 0.0553 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0041 | 0.0118 |
Onchocerca volvulus | 0.0237 | 0.2164 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0405 | 0.3835 | 1 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0405 | 0.3835 | 0.5147 |
Echinococcus multilocularis | geminin | 0.0371 | 0.3498 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0041 | 0.0219 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0107 | 0.0874 | 0.465 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0107 | 0.0874 | 0.2498 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.1027 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0454 | 0.2414 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0113 | 0.0602 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0196 | 0.3753 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0064 | 0.0454 | 0.1297 |
Echinococcus granulosus | geminin | 0.0371 | 0.3498 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0107 | 0.0874 | 0.2498 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0454 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0196 | 0.1043 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0405 | 0.3835 | 0.4919 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0208 | 0.1879 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0064 | 0.0454 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0041 | 0.0118 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0107 | 0.0874 | 0.2498 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0113 | 0.0323 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0107 | 0.0874 | 0.465 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0041 | 0.5 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.037 | 0.1971 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0196 | 0.056 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0286 | 0.2657 | 0.25 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0113 | 0.0323 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0113 | 0.0323 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.0186 | 0.0531 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0333 | 0.1772 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0196 | 0.056 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0113 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0454 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0174 | 0.1544 | 0.2524 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0119 | 0.0995 | 0.1603 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0623 | 0.5994 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0113 | 0.0323 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0286 | 0.2657 | 0.3392 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0102 | 0.0292 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.0041 | 0.0118 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.037 | 0.1058 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0041 | 0.0118 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0222 | 0.202 | 0.3325 |
Schistosoma mansoni | hypothetical protein | 0.0371 | 0.3498 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0196 | 0.3753 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0064 | 0.0454 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0064 | 0.0454 | 0.1297 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0222 | 0.202 | 0.1071 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0041 | 0.0219 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0041 | 0.0118 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.08 | 0.7752 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0064 | 0.0454 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0623 | 0.5994 | 0.772 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0056 | 0.037 | 0.798 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0113 | 0.0323 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0107 | 0.0874 | 0.2498 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0113 | 0.0323 |
Brugia malayi | Pre-SET motif family protein | 0.0208 | 0.1879 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.037 | 0.1058 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0623 | 0.5994 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.0041 | 0.0118 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0107 | 0.0874 | 0.2498 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0196 | 0.056 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.1027 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0371 | 0.3498 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0064 | 0.0454 | 0.2414 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.037 | 0.1058 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0196 | 0.056 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0113 | 0.0602 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0041 | 0.0118 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0196 | 0.3753 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | < 20 % | In vitro inhibition of cell growth (Cytostatic activity) of mouse leukemia L1210 cells (ATCC CCL 219); inhibition @ 10 uM/L | ChEMBL. | 10794698 |
Inhibition (functional) | < 20 % | In vitro inhibition of cell growth (Cytostatic activity) of human cervix carcinoma HeLa S3 cells (ATCC CCL 2.2); inhibition @ 10 uM/L | ChEMBL. | 10794698 |
Inhibition (functional) | < 20 % | In vitro inhibition of cell growth (Cytostatic activity) of human T-lymphoblastoid CCRF-CEM cell line (ATCC CCL 119); inhibition @ 10 uM/L | ChEMBL. | 10794698 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.