Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0301 | 1 | 1 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0301 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.3176 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.3176 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.3176 | 0.5 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0301 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.2127 | 0.5 |
Onchocerca volvulus | 0.0091 | 0 | 0.5 | |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.2127 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.3176 | 0.5 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0293 | 0.9601 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.3176 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | = 25 min | Half-life of the compound was determined using mouse brain homogenate | ChEMBL. | 12643900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.