Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0456 | 0.3409 | 0.3409 |
Brugia malayi | YY1-associated factor 2 | 0.0456 | 0.3409 | 0.3409 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0456 | 0.3409 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.1282 | 1 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.1282 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1282 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.1282 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0456 | 0.3409 | 0.3409 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1282 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1282 | 1 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0029 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0456 | 0.3409 | 0.3409 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0456 | 0.3409 | 0.3409 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0148 | 0.0951 | 0.0951 |
Leishmania major | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0456 | 0.3409 | 0.3409 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.1282 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.1282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.3409 | 0.3409 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0456 | 0.3409 | 0.3409 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1282 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.1282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0951 | 0.0951 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.1282 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0456 | 0.3409 | 0.3409 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0456 | 0.3409 | 0.3409 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.1282 | 1 | 1 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0456 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.3409 | 0.3409 |
Toxoplasma gondii | ran binding protein | 0.0456 | 0.3409 | 0.3409 |
Leishmania major | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Schistosoma mansoni | RNA binding protein | 0.0456 | 0.3409 | 0.3409 |
Onchocerca volvulus | 0.0456 | 0.3409 | 0.3409 | |
Echinococcus granulosus | tumor protein p63 | 0.1011 | 0.784 | 0.784 |
Echinococcus multilocularis | tumor protein p63 | 0.1011 | 0.784 | 0.784 |
Trichomonas vaginalis | set domain proteins, putative | 0.0189 | 0.1281 | 0.1281 |
Brugia malayi | Pre-SET motif family protein | 0.0166 | 0.1098 | 0.1098 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0456 | 0.3409 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0456 | 0.3409 | 0.3409 |
Chlamydia trachomatis | DNA topoisomerase I | 0.1282 | 1 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.1282 | 1 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.1282 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1282 | 1 | 1 |
Onchocerca volvulus | 0.0148 | 0.0951 | 0.0951 | |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0456 | 0.3409 | 0.3409 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0456 | 0.3409 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0456 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.3409 | 0.3409 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0166 | 0.1098 | 0.1098 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.3409 | 0.3409 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0456 | 0.3409 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0456 | 0.3409 | 0.3409 |
Onchocerca volvulus | 0.0456 | 0.3409 | 0.3409 | |
Echinococcus granulosus | SWI:SNF matrix associated | 0.1282 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0456 | 0.3409 | 0.3409 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0456 | 0.3409 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0456 | 0.3409 | 1 |
Onchocerca volvulus | 0.0189 | 0.1281 | 0.1281 | |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0456 | 0.3409 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0456 | 0.3409 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.1282 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.3409 | 0.3409 |
Leishmania major | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0029 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Schistosoma mansoni | fusion | 0.0456 | 0.3409 | 0.3409 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0184 | 0.1238 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.1282 | 1 | 1 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0456 | 0.3409 | 0.3409 |
Brugia malayi | brahma associated protein 60 kDa | 0.1282 | 1 | 1 |
Onchocerca volvulus | 0.0456 | 0.3409 | 0.3409 | |
Loa Loa (eye worm) | brahma associated protein | 0.1282 | 1 | 1 |
Onchocerca volvulus | 0.0456 | 0.3409 | 0.3409 | |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0456 | 0.3409 | 0.3409 |
Leishmania major | hypothetical protein, conserved | 0.0456 | 0.3409 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1282 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.1282 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1282 | 1 | 1 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0456 | 0.3409 | 0.3409 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0456 | 0.3409 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0029 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -4 | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
IC50 (binding) | > 100 uM | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
IC50 (binding) | > 100 uM | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
Log IC50 (binding) | = -4 | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
Relative potency (binding) | < 0.01 | Ratio of inhibitory activity of compound against HMG-CoA reductase to that of compactin | ChEMBL. | 2296019 |
Relative potency (binding) | < 0.01 | Ratio of inhibitory activity of compound against HMG-CoA reductase to that of compactin | ChEMBL. | 2296019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.