Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | eukaryotic translation initiation factor 4E | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | eukaryotic translation initiation factor 4E-1 | eukaryotic translation initiation factor 4E | 237 aa | 190 aa | 44.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | plexin a4 | 0.0044 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0.7608 | 1 | |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0042 | 0.9245 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.2147 | 0.2323 |
Brugia malayi | translation initiation factor 4E | 0.0042 | 0.9245 | 0.9245 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0042 | 0.9245 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0044 | 1 | 1 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0042 | 0.9245 | 1 |
Brugia malayi | Plexin repeat family protein | 0.0037 | 0.7608 | 0.7608 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0042 | 0.9245 | 0.5 |
Schistosoma mansoni | plexin | 0.0022 | 0.2147 | 0.2323 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0042 | 0.9245 | 0.9245 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0042 | 0.9245 | 0.9245 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0042 | 0.9245 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0042 | 0.9245 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0042 | 0.9245 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.7608 | 0.7608 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0042 | 0.9245 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0042 | 0.9245 | 0.5 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0042 | 0.9245 | 0.5 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0042 | 0.9245 | 0.5 |
Loa Loa (eye worm) | plexin A | 0.0044 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0042 | 0.9245 | 0.5 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0042 | 0.9245 | 0.5 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0042 | 0.9245 | 0.5 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0042 | 0.9245 | 0.9245 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.2147 | 0.2147 |
Schistosoma mansoni | plexin | 0.0037 | 0.7608 | 0.8229 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 uM | Inhibitory concentration against 7-methyl-GTP binding to eukaryotic translation initiation factor 4E | ChEMBL. | 15808492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.