TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 767.011 | Formula: C52H54N4O2++
H donors: 0 H acceptors: 0 LogP: 6.95 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: c1ccc(cc1)C[N@+]12CC[C@@]34[C@@H]2C[C@H]2C(=CCO[C@@H]5[C@H]2[C@@H]3N(c2c4cccc2)[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N5c5ccccc5[C@]52CC[N@+]([C@H]5C4)(C3)Cc2ccccc2)C1
InChi: 1S/C52H54N4O2/c1-3-11-33(12-4-1)29-55-23-21-51-39-15-7-9-17-41(39)53-47(51)45-37(27-43(51)55)35(31-55)19-25-57-49(45)54-42-18-10-8-16-40(42)52-22-24-56(30-34-13-5-2-6-14-34)32-36-20-26-58-50(53)46(48(52)54)38(36)28-44(52)56/h1-20,37-38,43-50H,21-32H2/q+2/t37-,38-,43-,44-,45+,46+,47-,48-,49+,50+,51+,52+,55+,56+/m0/s1
InChiKey: IXWVDIIFVCHSRO-KUAGRDSLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	0.2916	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	1
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0042	0.1301	0.1301
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0079	0.346	0.346
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0122	0.0182
Trypanosoma cruzi	short chain dehydrogenase, putative	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.007	0.2916	0.2916
Onchocerca volvulus		0.007	0.2916	0.4349
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Echinococcus granulosus	hypothetical protein	0.007	0.2916	0.2916
Mycobacterium ulcerans	ketoacyl reductase	0.007	0.2916	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Onchocerca volvulus		0.007	0.2916	0.4349
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Echinococcus multilocularis	carbonyl reductase 1	0.007	0.2916	0.2916
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Brugia malayi	oxidoreductase	0.007	0.2916	0.4349
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Echinococcus multilocularis	retinol dehydrogenase 11	0.007	0.2916	0.2916
Brugia malayi	Cytochrome P450 family protein	0.0035	0.0831	0.124
Leishmania major	pteridine reductase 1	0.007	0.2916	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.007	0.2916	1
Giardia lamblia	Short-chain dehydrogenase, putative	0.007	0.2916	1
Leishmania major	hypothetical protein, conserved	0.007	0.2916	1
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.007	0.2916	1
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Mycobacterium ulcerans	ketoacyl reductase	0.007	0.2916	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.007	0.2916	1
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.007	0.2916	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Onchocerca volvulus	Huntingtin homolog	0.0134	0.6704	1
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.007	0.2916	0.2916
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.007	0.2916	1
Schistosoma mansoni	carbonyl reductase	0.007	0.2916	0.2916
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.007	0.2916	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.007	0.2916	1
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.2916	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	0.2916	1
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.2916	1
Echinococcus granulosus	carbonyl reductase 1	0.007	0.2916	0.2916
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.007	0.2916	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.007	0.2916	1
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0122	0.0182
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.2916	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0079	0.346	0.346
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	0.2916	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.007	0.2916	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.007	0.2916	0.2916
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.007	0.2916	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	0.2916	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	0.2916	1
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.007	0.2916	1
Brugia malayi	dehydrogenases, short chain protein 9	0.007	0.2916	0.4349
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0042	0.1301	0.1941
Echinococcus multilocularis	steroid dehydrogenase	0.007	0.2916	0.2916
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0122	0.0182
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0042	0.1301	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Echinococcus multilocularis	geminin	0.019	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.007	0.2916	1
Plasmodium vivax	hypothetical protein, conserved	0.007	0.2916	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	1
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.007	0.2916	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.007	0.2916	1
Entamoeba histolytica	hypothetical protein	0.0079	0.346	1
Schistosoma mansoni	hypothetical protein	0.019	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Trichomonas vaginalis	steroid dehydrogenase, putative	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.165	0.246
Echinococcus multilocularis	transient receptor potential cation channel	0.007	0.2916	0.2916
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.007	0.2916	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0042	0.1301	0.1941
Echinococcus granulosus	carbonyl reductase 1	0.007	0.2916	0.2916
Leishmania major	short chain dehydrogenase, putative	0.007	0.2916	1
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.007	0.2916	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	0.2916	1
Entamoeba histolytica	hypothetical protein	0.007	0.2916	0.748
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.007	0.2916	0.2916
Giardia lamblia	Hypothetical protein	0.007	0.2916	1
Mycobacterium ulcerans	carveol-like dehydrogenase	0.007	0.2916	1
Onchocerca volvulus		0.007	0.2916	0.4349
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.007	0.2916	0.748
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.007	0.2916	1
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.007	0.2916	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0042	0.1301	0.4221
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.007	0.2916	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	0.2916	1
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.007	0.2916	0.2916
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Leishmania major	short chain dehydrogenase-like protein	0.007	0.2916	1
Onchocerca volvulus		0.007	0.2916	0.4349
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.007	0.2916	0.4349
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Onchocerca volvulus		0.007	0.2916	0.4349
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.007	0.2916	0.748
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Schistosoma mansoni	hypothetical protein	0.019	1	1
Echinococcus granulosus	hypothetical protein	0.007	0.2916	0.2916
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.007	0.2916	1
Plasmodium vivax	steroid dehydrogenase, putative	0.007	0.2916	1
Brugia malayi	hypothetical protein	0.0134	0.6704	1
Echinococcus multilocularis	carbonyl reductase 1	0.007	0.2916	0.2916
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.007	0.2916	1
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Leishmania major	hypothetical protein, conserved	0.007	0.2916	1
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.007	0.2916	0.2916
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.007	0.2916	1
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0745	0.1111
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.2916	1
Loa Loa (eye worm)	dehydrogenase	0.007	0.2916	0.4349
Leishmania major	quinonoid dihydropteridine reductase	0.007	0.2916	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	1
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.007	0.2916	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0122	0.0182
Giardia lamblia	Reductase, putative	0.007	0.2916	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.007	0.2916	0.4349
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Brugia malayi	Dehydrogenases, short chain protein 30	0.007	0.2916	0.4349
Brugia malayi	Retinol dehydrogenase 12	0.007	0.2916	0.4349
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	0.2916	1
Leishmania major	3-keto-dihydrosphingosine reductase	0.007	0.2916	1
Echinococcus granulosus	carbonyl reductase 1	0.007	0.2916	0.2916
Echinococcus multilocularis	oxidoreductase	0.007	0.2916	0.2916
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.007	0.2916	1
Onchocerca volvulus	Sepiapterin reductase homolog	0.007	0.2916	0.4349
Echinococcus granulosus	oxidoreductase	0.007	0.2916	0.2916
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.007	0.2916	1
Leishmania major	quinonoid dihydropteridine reductase	0.007	0.2916	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	0.2916	1
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.007	0.2916	0.2916
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.007	0.2916	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Entamoeba histolytica	hypothetical protein	0.0079	0.346	1
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.007	0.2916	0.4349
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0042	0.1301	0.4221
Leishmania major	quinonoid dihydropteridine reductase	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Leishmania major	oxidoreductase-like protein	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Mycobacterium tuberculosis	Probable dehydrogenase	0.007	0.2916	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Entamoeba histolytica	hypothetical protein, conserved	0.007	0.2916	0.748
Schistosoma mansoni	hypothetical protein	0.0033	0.0745	0.0745
Echinococcus multilocularis	retinol dehydrogenase 13	0.007	0.2916	0.2916
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Mycobacterium ulcerans	short-chain dehydrogenase	0.007	0.2916	1
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	0.5
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.007	0.2916	0.2916
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.007	0.2916	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	1
Schistosoma mansoni	ap endonuclease	0.0042	0.1301	0.1301
Mycobacterium ulcerans	dehydrogenase/reductase	0.007	0.2916	1
Mycobacterium ulcerans	oxidoreductase	0.007	0.2916	1
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.007	0.2916	0.4349
Schistosoma mansoni	ap endonuclease	0.0042	0.1301	0.1301
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.007	0.2916	1
Schistosoma mansoni	hypothetical protein	0.0079	0.346	0.346
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.007	0.2916	1
Onchocerca volvulus		0.007	0.2916	0.4349
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Leishmania major	short chain dehydrogenase/reductase, putative	0.007	0.2916	1
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0122	0.0182
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	1
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.007	0.2916	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0042	0.1301	0.4221
Mycobacterium ulcerans	dehydrogenase	0.007	0.2916	1
Toxoplasma gondii	oxidoreductase, putative	0.007	0.2916	1
Leishmania major	quinonoid dihydropteridine reductase	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.165	0.246
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.6704	1
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Echinococcus multilocularis	carbonyl reductase 1	0.007	0.2916	0.2916
Toxoplasma gondii	carbonyl reductase 1, putative	0.007	0.2916	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.007	0.2916	1
Entamoeba histolytica	short chain dehydrogenase family protein	0.007	0.2916	0.748
Loa Loa (eye worm)	dehydrogenase	0.007	0.2916	0.4349
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	0.2916	1
Mycobacterium leprae	Probable oxidoreductase	0.007	0.2916	0.5
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Entamoeba histolytica	hypothetical protein	0.0079	0.346	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0035	0.0831	0.124
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0042	0.1301	0.1301
Onchocerca volvulus		0.007	0.2916	0.4349
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Leishmania major	quinonoid dihydropteridine reductase	0.007	0.2916	1
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.007	0.2916	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.007	0.2916	0.2916
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Onchocerca volvulus		0.007	0.2916	0.4349
Entamoeba histolytica	short chain dehydrogenase family protein	0.007	0.2916	0.748
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Echinococcus multilocularis	conserved hypothetical protein	0.007	0.2916	0.2916
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.007	0.2916	1
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Brugia malayi	Dehydrogenases, short chain protein 2	0.007	0.2916	0.4349
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.165	0.246
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	1
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.007	0.2916	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.007	0.2916	1
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.007	0.2916	0.2916
Brugia malayi	hypothetical protein	0.007	0.2916	0.4349
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.007	0.2916	0.4349
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.007	0.2916	0.748
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Onchocerca volvulus		0.007	0.2916	0.4349
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Mycobacterium ulcerans	oxidoreductase	0.007	0.2916	1
Leishmania major	quinonoid dihydropteridine reductase	0.007	0.2916	1
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.007	0.2916	0.2916
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Leishmania major	hypothetical protein, conserved	0.007	0.2916	1
Schistosoma mansoni	carbonyl reductase	0.007	0.2916	0.2916
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0745	0.1111
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	1
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	0.5
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	0.2916	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	0.2916	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.007	0.2916	0.4349
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.007	0.2916	1
Onchocerca volvulus		0.007	0.2916	0.4349
Echinococcus granulosus	retinol dehydrogenase 11	0.007	0.2916	0.2916
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.007	0.2916	1
Leishmania major	hypothetical protein, conserved	0.007	0.2916	1
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Trypanosoma brucei	oxidoreductase-like protein	0.007	0.2916	1
Leishmania major	short chain dehydrogenase, putative	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.6704	1
Onchocerca volvulus		0.007	0.2916	0.4349
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.007	0.2916	0.2916
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.007	0.2916	0.748
Schistosoma mansoni	carbonyl reductase	0.007	0.2916	0.2916
Echinococcus multilocularis	carbonyl reductase 1	0.007	0.2916	0.2916
Brugia malayi	dehydrogenases, short chain protein 2	0.007	0.2916	0.4349
Schistosoma mansoni	retinal dehydrogenase	0.007	0.2916	0.2916
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.007	0.2916	0.748
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Leishmania major	quinonoid dihydropteridine reductase	0.007	0.2916	1
Mycobacterium ulcerans	short-chain type oxidoreductase	0.007	0.2916	1
Schistosoma mansoni	transcription factor LCR-F1	0.0079	0.346	0.346
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	1
Leishmania major	dehydrogenase-like protein	0.007	0.2916	1
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.007	0.2916	1
Echinococcus multilocularis	retinol dehydrogenase 11	0.007	0.2916	0.2916
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.007	0.2916	0.2916
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.007	0.2916	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	0.4349
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.165	0.246
Mycobacterium ulcerans	ketoacyl reductase	0.007	0.2916	1
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.2916	1
Onchocerca volvulus		0.007	0.2916	0.4349
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.007	0.2916	1
Schistosoma mansoni	short chain dehydrogenase	0.007	0.2916	0.2916
Plasmodium falciparum	steroid dehydrogenase, putative	0.007	0.2916	1
Onchocerca volvulus		0.007	0.2916	0.4349
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0042	0.1301	0.4221
Onchocerca volvulus	Huntingtin homolog	0.0134	0.6704	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0042	0.1301	0.4221
Echinococcus granulosus	carbonyl reductase 1	0.007	0.2916	0.2916
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	0.2916	1
Echinococcus multilocularis	steroid dehydrogenase	0.007	0.2916	0.2916
Echinococcus granulosus	WW domain containing oxidoreductase	0.007	0.2916	0.2916
Echinococcus granulosus	steroid dehydrogenase	0.007	0.2916	0.2916
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	0.2916	1
Entamoeba histolytica	hypothetical protein	0.0079	0.346	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.007	0.2916	0.4349
Brugia malayi	hypothetical protein	0.007	0.2916	0.4349
Brugia malayi	hypothetical protein	0.0079	0.346	0.5161
Leishmania major	hypothetical protein, conserved	0.007	0.2916	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.007	0.2916	1
Entamoeba histolytica	hypothetical protein, conserved	0.007	0.2916	0.748
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.007	0.2916	1
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Mycobacterium ulcerans	short chain dehydrogenase	0.007	0.2916	1
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.007	0.2916	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.007	0.2916	1
Echinococcus granulosus	retinol dehydrogenase 11	0.007	0.2916	0.2916
Mycobacterium tuberculosis	Probable oxidoreductase	0.007	0.2916	1
Loa Loa (eye worm)	oxidoreductase	0.007	0.2916	0.4349
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.007	0.2916	1
Schistosoma mansoni	steroid dehydrogenase	0.007	0.2916	0.2916
Trypanosoma brucei	short-chain dehydrogenase, putative	0.007	0.2916	1
Toxoplasma gondii	oxidoreductase, putative	0.007	0.2916	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.2916	0.4349

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2365146

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1746351