TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 401.564 | Formula: C27H33N2O+
H donors: 0 H acceptors: 0 LogP: 6.88 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCn1c2cc(OCC(C)C)ccc2c2c1c(C)[n+](cc2)Cc1ccccc1
InChi: 1S/C27H33N2O/c1-5-6-15-29-26-17-23(30-19-20(2)3)12-13-24(26)25-14-16-28(21(4)27(25)29)18-22-10-8-7-9-11-22/h7-14,16-17,20H,5-6,15,18-19H2,1-4H3/q+1
InChiKey: RIUBAERVSGXLJN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cleavage and polyadenylation specificity factor, putative	0.0263	0.5703	1
Trichomonas vaginalis	conserved hypothetical protein	0.0263	0.5703	1
Mycobacterium tuberculosis	Conserved protein	0.0263	0.5703	0.5703
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1929	0.3382
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0762	0.1336
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0263	0.5703	0.7744
Trypanosoma cruzi	glyoxalase II	0.0263	0.5703	1
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0263	0.5703	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0444	0.0778
Echinococcus granulosus	GPCR family 2	0.0016	0.0041	0.0055
Entamoeba histolytica	heat shock transcription factor, putative	0.0098	0.1929	0.3382
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0052	0.088	0.1543
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0026	0.0046
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0071
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0041	0.0071
Schistosoma mansoni	zinc phosphodiesterase	0.0263	0.5703	1
Mycobacterium leprae	Beta-lactamase-like protein	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0706	0.1238
Trichomonas vaginalis	conserved hypothetical protein	0.0263	0.5703	1
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0288	0.0506
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0041	0.0055
Schistosoma mansoni	hypothetical protein	0.0263	0.5703	1
Leishmania major	hypothetical protein, conserved	0.0071	0.1298	0.2276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0294	0.0516
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0263	0.5703	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0445	0.0445
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0263	0.5703	1
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0808	0.1416
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0263	0.5703	0.5703
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0902	0.1582
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0236	0.0413
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0762	0.1336
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0336	0.059
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0762	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0249	0.0437
Schistosoma mansoni	hypothetical protein	0.0034	0.0455	0.0798
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0445	0.0445
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1298	0.2276
Echinococcus granulosus	lamin dm0	0.0053	0.0902	0.1225
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0236	0.0413
Onchocerca volvulus		0.0049	0.0808	0.1416
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0762	0.1336
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1298	0.2276
Entamoeba histolytica	type A flavoprotein, putative	0.0263	0.5703	1
Entamoeba histolytica	heat shock transcription factor, putative	0.0098	0.1929	0.3382
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.1298	0.2276
Brugia malayi	ethe1-prov protein	0.0263	0.5703	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0808	0.1416
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1298	0.1298
Plasmodium vivax	hydroxyacyl glutathione hydrolase, putative	0.0263	0.5703	1
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0263	0.5703	1
Mycobacterium tuberculosis	Conserved protein	0.0263	0.5703	0.5703
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0444	0.0778
Mycobacterium leprae	conserved hypothetical protein	0.0263	0.5703	1
Trypanosoma brucei	cleavage and polyadenylation specificity factor subunit, putative	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0026	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0762	0.1336
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0706	0.1238
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.0706	0.1238
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0263	0.5703	0.7744
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0762	0.1336
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0497	0.0871
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1298	0.1298
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0236	0.0413
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.0706	0.0959
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0167	0.0293
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.0706	0.1238
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.0108	0.019
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0762	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1298	0.2276
Loa Loa (eye worm)	beta-lactamase	0.0071	0.1298	0.2276
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0041	0.0055
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0762	0.1336
Trichomonas vaginalis	conserved hypothetical protein	0.0263	0.5703	1
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0263	0.5703	1
Loa Loa (eye worm)	hypothetical protein	0.0263	0.5703	1
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.1298	0.2276
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0272	0.0369
Mycobacterium ulcerans	hydrolase	0.0263	0.5703	1
Mycobacterium ulcerans	hydrolase	0.0263	0.5703	1
Wolbachia endosymbiont of Brugia malayi	metallo-beta-lactamase superfamily hydrolase	0.0263	0.5703	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0294	0.0516
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0015	0.0026	0.0046
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0263	0.5703	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0492	0.0862
Brugia malayi	hypothetical protein	0.0263	0.5703	1
Mycobacterium tuberculosis	Conserved protein	0.0263	0.5703	0.5703
Schistosoma mansoni	hypothetical protein	0.0263	0.5703	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.2365	0.4147
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0492	0.0862
Mycobacterium ulcerans	beta lactamase-like protein	0.0263	0.5703	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0272	0.0369
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0263	0.5703	0.7744
Schistosoma mansoni	lamin	0.0053	0.0902	0.1582
Entamoeba histolytica	hypothetical protein	0.0035	0.0492	0.0862
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0444	0.0778
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.1298	0.1763
Brugia malayi	hypothetical protein	0.0035	0.0492	0.0862
Entamoeba histolytica	alkyl sulfatase, putative	0.0263	0.5703	1
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0098	0.1929	0.3382
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0071	0.1298	0.1298
Trypanosoma cruzi	glyoxalase II	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0706	0.1238
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.0706	0.1238
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0489	0.0858
Trichomonas vaginalis	A-type flavoprotein	0.0263	0.5703	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0336	0.059
Mycobacterium ulcerans	lipase LipD	0.0071	0.1298	0.2276
Trichomonas vaginalis	beta lactamase domain, putative	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0235	0.0412
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.0706	0.1238
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0041	0.0055
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0263	0.5703	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0071	0.1298	0.1298
Echinococcus multilocularis	zinc phosphodiesterase	0.0263	0.5703	0.7744
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0498	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0902	0.1582
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0263	0.5703	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1298	0.2276
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0015	0.0026	0.0046
Leishmania major	hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative	0.0263	0.5703	1
Echinococcus granulosus	geminin	0.0166	0.349	0.4739
Mycobacterium tuberculosis	Possible hydrolase	0.0263	0.5703	0.5703
Mycobacterium tuberculosis	Probable lipase LipD	0.0071	0.1298	0.1298
Schistosoma mansoni	hypothetical protein	0.0166	0.349	0.6119
Schistosoma mansoni	zinc phosphodiesterase	0.0263	0.5703	1
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0263	0.5703	1
Entamoeba histolytica	type A flavoprotein, putative	0.0263	0.5703	1
Trypanosoma cruzi	glyoxalase II	0.0263	0.5703	1
Schistosoma mansoni	hypothetical protein	0.0263	0.5703	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.1298	0.2276
Brugia malayi	MH2 domain containing protein	0.0117	0.2365	0.4147
Echinococcus multilocularis	musashi	0.0053	0.0902	0.1225
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0556	0.0976
Treponema pallidum	ribonuclease Z	0.0263	0.5703	0.5
Trypanosoma brucei	hydroxyacylglutathione hydrolase, putative	0.0263	0.5703	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0489	0.0858
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0041	0.0055
Mycobacterium leprae	POSSIBLE HYDROLASE	0.0263	0.5703	1
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0263	0.5703	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0492	0.0862
Echinococcus granulosus	ETHE1 protein	0.0263	0.5703	0.7744
Loa Loa (eye worm)	hypothetical protein	0.0263	0.5703	1
Schistosoma mansoni	lamin	0.0053	0.0902	0.1582
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0263	0.5703	1
Leishmania major	hypothetical protein, conserved	0.0263	0.5703	1
Onchocerca volvulus	Putative hydrolase PNKD	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0497	0.0871
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0026	0.0046
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0263	0.5703	0.7744
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0497	0.0871
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0762	0.1336
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0444	0.0778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0444	0.0778
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0762	0.1336
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0369	0.0648
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0041	0.0071
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0263	0.5703	1
Mycobacterium ulcerans	glyoxalase II, GloB	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0026	0.0046
Mycobacterium ulcerans	hypothetical protein	0.0071	0.1298	0.2276
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0762	0.1336
Entamoeba histolytica	alkyl sulfatase, putative	0.0263	0.5703	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0489	0.0858
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.1298	0.2276
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0263	0.5703	1
Brugia malayi	intermediate filament protein	0.0053	0.0902	0.1582
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0812	0.1424
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0294	0.0516
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.1298	0.2276
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1298	0.2276
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0489	0.0858
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0263	0.5703	1
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.1298	0.2276
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0455	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1298	0.2276
Leishmania major	metallo-beta-lactamase family-like protein	0.0263	0.5703	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.1298	0.1763
Schistosoma mansoni	hypothetical protein	0.0166	0.349	0.6119
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.1298	0.2276
Mycobacterium ulcerans	hypothetical protein	0.0263	0.5703	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0071	0.1298	0.1298
Trichomonas vaginalis	conserved hypothetical protein	0.0263	0.5703	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0902	0.1582
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0762	0.1336
Mycobacterium tuberculosis	Beta lactamase like protein	0.0263	0.5703	0.5703
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0026	0.0046
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0263	0.5703	0.5703
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1298	0.2276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0026	0.0046
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0762	0.1336
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.1298	0.2276
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0249	0.0437
Trichomonas vaginalis	beta lactamase domain, putative	0.0263	0.5703	1
Plasmodium vivax	unspecified product	0.0263	0.5703	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0762	0.1336
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0497	0.0871
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0497	0.0871
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0706	0.1238
Toxoplasma gondii	ABC1 family protein	0.0071	0.1298	0.2276
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0812	0.1424
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.0706	0.1238
Trichomonas vaginalis	beta lactamase domain, putative	0.0263	0.5703	1
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0762	0.1336
Chlamydia trachomatis	ribonuclease Z	0.0263	0.5703	1
Onchocerca volvulus		0.0263	0.5703	1
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0263	0.5703	1
Mycobacterium ulcerans	hypothetical protein	0.0263	0.5703	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0812	0.1424
Mycobacterium leprae	conserved hypothetical protein	0.0263	0.5703	1
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0263	0.5703	0.7744
Onchocerca volvulus		0.0071	0.1298	0.2276
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0263	0.5703	0.5703
Brugia malayi	beta-lactamase	0.0071	0.1298	0.2276
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.0026	0.0036
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.0706	0.1238
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0263	0.5703	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1298	0.2276
Plasmodium falciparum	cytosolic glyoxalase II	0.0263	0.5703	1
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0263	0.5703	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0263	0.5703	1
Brugia malayi	beta-lactamase family protein	0.0071	0.1298	0.2276
Mycobacterium ulcerans	Zn-dependent glyoxylase	0.0263	0.5703	1
Onchocerca volvulus		0.0071	0.1298	0.2276
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0455	0.0798
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0026	0.0046
Onchocerca volvulus		0.0047	0.0762	0.1336
Onchocerca volvulus		0.0071	0.1298	0.2276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0444	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0263	0.5703	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.1298	0.2276
Echinococcus multilocularis	tumor protein p63	0.0336	0.7364	1
Onchocerca volvulus		0.0053	0.0902	0.1582
Trichomonas vaginalis	beta lactamase domain, putative	0.0263	0.5703	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0762	0.0762
Mycobacterium leprae	Probable lipase LipE	0.0071	0.1298	0.2276
Entamoeba histolytica	heat shock transcription factor, putative	0.0098	0.1929	0.3382
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.1298	0.2276
Entamoeba histolytica	hypothetical protein, conserved	0.0263	0.5703	1
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0263	0.5703	0.7744
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0489	0.0858
Entamoeba histolytica	hypothetical protein	0.0035	0.0492	0.0862
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0812	0.1424
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0706	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0263	0.5703	1
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0263	0.5703	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0489	0.0858
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.0706	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0041	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.0263	0.5703	1
Echinococcus multilocularis	geminin	0.0166	0.349	0.4739
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0015	0.0026	0.0046
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0015	0.0026	0.0046
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0263	0.5703	1
Echinococcus granulosus	intermediate filament protein	0.0053	0.0902	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0489	0.0858
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0762	0.1336
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.0706	0.0959
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0762	0.1336
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0263	0.5703	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0762	0.1336
Trichomonas vaginalis	conserved hypothetical protein	0.0263	0.5703	1
Giardia lamblia	Hydroxyacylglutathione hydrolase	0.0263	0.5703	1
Trypanosoma brucei	glyoxalase II	0.0263	0.5703	1
Mycobacterium ulcerans	hypothetical protein	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0236	0.0413
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0902	0.1582
Echinococcus granulosus	zinc phosphodiesterase	0.0263	0.5703	0.7744
Echinococcus granulosus	tumor protein p63	0.0336	0.7364	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0071	0.1298	0.1298
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0347	0.0609
Echinococcus multilocularis	ETHE1 protein	0.0263	0.5703	0.7744
Mycobacterium ulcerans	beta-lactamase	0.0071	0.1298	0.2276
Mycobacterium ulcerans	hydrolase	0.0263	0.5703	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0444	0.0778
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0762	0.0762
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.2365	0.4147
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0041	0.0071
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1298	0.2276
Mycobacterium tuberculosis	Conserved protein	0.0071	0.1298	0.1298
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0071	0.1298	0.1298
Trichomonas vaginalis	beta lactamase domain, putative	0.0263	0.5703	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0489	0.0489
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.0026	0.0036
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0762	0.1336
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0098	0.1929	0.3382
Brugia malayi	beta-lactamase family protein	0.0071	0.1298	0.2276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0235	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1298	0.2276
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0272	0.0476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0444	0.0778
Echinococcus multilocularis	lamin dm0	0.0053	0.0902	0.1225
Mycobacterium tuberculosis	Probable hydrolase	0.0071	0.1298	0.1298
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.0498	0.0872
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.0498	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0762	0.1336
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0263	0.5703	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0071
Echinococcus multilocularis	lamin	0.0053	0.0902	0.1225
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0015	0.0026	0.0046
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0706	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0489	0.0858
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0288	0.0506
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0445	0.0445
Trichomonas vaginalis	esterase, putative	0.0071	0.1298	0.2276
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0492	0.0667
Mycobacterium tuberculosis	Possible hydrolase	0.0263	0.5703	0.5703
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0026	0.0046
Leishmania major	metallo-beta-lactamase family protein-like protein	0.0263	0.5703	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.1298	0.2276
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0762	0.1336
Onchocerca volvulus		0.0053	0.0902	0.1582
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0902	0.1582
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0041	0.0055
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.1298	0.2276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0235	0.0412
Giardia lamblia	Metallo-beta-lactamase superfamily protein	0.0263	0.5703	1
Echinococcus granulosus	lamin	0.0053	0.0902	0.1225
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0445	0.0445
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0762	0.1336
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0263	0.5703	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0492	0.0862
Schistosoma mansoni	hypothetical protein	0.0016	0.0041	0.0071
Onchocerca volvulus		0.0263	0.5703	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0026	0.0046
Mycobacterium ulcerans	hypothetical protein	0.0263	0.5703	1
Trypanosoma brucei	metallo-beta-lactamase-like protein, putative	0.0263	0.5703	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.0706	0.1238
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0492	0.0667

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2365931

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1747823