Detailed information for compound 1748599

Basic information

Technical information
  • TDR Targets ID: 1748599
  • Name: AO-990/37423003
  • MW: 444.348 | Formula: C19H18BrN5OS
  • H donors: 1 H acceptors: 1 LogP: 4.3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N=C(SCc1c(Br)c(=O)n(n1C)c1ccccc1)N/N=C/c1ccccc1
  • InChi: 1S/C19H18BrN5OS/c1-24-16(17(20)18(26)25(24)15-10-6-3-7-11-15)13-27-19(21)23-22-12-14-8-4-2-5-9-14/h2-12H,13H2,1H3,(H2,21,23)/b22-12+
  • InChiKey: IKDQCSKJWXSHPJ-WSDLNYQXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(4-bromo-2-methyl-5-oxo-1-phenylpyrazol-3-yl)methylsulfanyl]-N'-(phenylmethylideneamino)methanimidamide
  • 1-[(4-bromo-2-methyl-5-oxo-1-phenyl-pyrazol-3-yl)methylsulfanyl]-N'-(phenylmethyleneamino)formamidine
  • 1-[(4-bromo-2-methyl-5-oxo-1-phenyl-3-pyrazolyl)methylthio]-N'-(phenylmethyleneamino)formamidine
  • N'-(benzylideneamino)-1-[(4-bromo-5-keto-2-methyl-1-phenyl-pyrazol-3-yl)methylthio]formamidine
  • 1-[(4-bromo-2-methyl-5-oxo-1-phenyl-pyrazol-3-yl)methylsulfanyl]-N'-(phenylmethylideneamino)methanimidamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0035 0.4971 0.4971
Schistosoma mansoni C-fyn 0.0029 0.4037 0.4037
Echinococcus granulosus expressed protein 0.0029 0.4037 0.4037
Schistosoma mansoni sorbin 0.0029 0.4037 0.4037
Brugia malayi Myosin tail family protein 0.0029 0.4037 0.4037
Brugia malayi Spectrin alpha chain 0.0029 0.4037 0.4037
Loa Loa (eye worm) AUR protein kinase 0.0064 1 1
Trypanosoma cruzi aurora B kinase, putative 0.0064 1 1
Echinococcus granulosus NCK adaptor protein 0.0034 0.4766 0.4766
Brugia malayi Variant SH3 domain containing protein 0.0029 0.4037 0.4037
Echinococcus multilocularis expressed protein 0.0029 0.4037 0.4037
Loa Loa (eye worm) hypothetical protein 0.0021 0.2703 0.2703
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0495 0.0546
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.2703 0.2323
Entamoeba histolytica hypothetical protein 0.0029 0.4037 0.4037
Schistosoma mansoni growth factor receptor-bound protein 0.0034 0.4766 0.4766
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0034 0.4766 0.4766
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0029 0.4037 0.4037
Schistosoma mansoni serine/threonine protein kinase 0.003 0.4241 0.4241
Loa Loa (eye worm) hypothetical protein 0.0034 0.4766 0.4766
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0021 0.2703 0.2703
Echinococcus multilocularis growth factor receptor bound protein 2 0.0034 0.4766 0.4766
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.3934 0.3934
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0495 0.0495
Toxoplasma gondii aurora kinase 0.0064 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.4037 0.3726
Echinococcus multilocularis aurora kinase A 0.0064 1 1
Onchocerca volvulus 0.003 0.4126 1
Echinococcus multilocularis transfer RNA-Ala 0.0029 0.4037 0.4037
Onchocerca volvulus Putative cortactin 0.0029 0.4037 0.9783
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.3934 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0035 0.506 0.506
Brugia malayi SRC-1 0.0035 0.4971 0.4971
Schistosoma mansoni sorting nexin 0.0029 0.4037 0.4037
Loa Loa (eye worm) SRC-1 0.0035 0.4971 0.4971
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0029 0.4037 0.4037
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.4037 0.3726
Schistosoma mansoni adapter molecule crk 0.0034 0.4766 0.4766
Echinococcus granulosus endophilin A3 0.0029 0.4037 0.4037
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0495 0.0495
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0495 0.0495
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0495 0.0546
Schistosoma mansoni formin binding protein and related proteins 0.0029 0.4037 0.4037
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0029 0.4037 0.4037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.4971 0.4971
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.4971 0.4971
Entamoeba histolytica unconventional myosin IB 0.0029 0.4037 0.4037
Loa Loa (eye worm) AUR protein kinase 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.2703 0.2703
Schistosoma mansoni hypothetical protein 0.0029 0.4037 0.4037
Echinococcus granulosus tyrosine protein kinase Fyn 0.0035 0.4971 0.4971
Brugia malayi Src substrate cortactin 0.0029 0.4037 0.4037
Trichomonas vaginalis AGC family protein kinase 0.0064 1 1
Leishmania major hypothetical protein, conserved 0.0029 0.4037 0.3726
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0035 0.4971 0.4971
Brugia malayi SH3 domain containing protein 0.0029 0.4037 0.4037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.2505 0.6071
Loa Loa (eye worm) hypothetical protein 0.0029 0.3934 0.3934
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.3934 1
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.4037 0.3726
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.3934 1
Brugia malayi Sex muscle abnormal protein 5 0.0034 0.4766 0.4766
Onchocerca volvulus 0.0029 0.4037 0.9783
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0029 0.4037 0.9783
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0029 0.4037 0.4037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.3934 1
Schistosoma mansoni tyrosine kinase 0.0035 0.4971 0.4971
Echinococcus multilocularis NCK adaptor protein 0.0034 0.4766 0.4766
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0495 0.0546
Onchocerca volvulus 0.0008 0.0495 0.12
Entamoeba histolytica protein kinase , putative 0.0064 1 1
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0029 0.4037 0.3726
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0064 1 1
Brugia malayi serine/threonine-protein kinase 6 0.0064 1 1
Trichomonas vaginalis AGC family protein kinase 0.0064 1 1
Brugia malayi Variant SH3 domain containing protein 0.0029 0.4037 0.4037
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0035 0.4971 0.4971
Schistosoma mansoni apoptosis stimulating of P53 0.0029 0.4037 0.4037
Brugia malayi Variant SH3 domain containing protein 0.0029 0.4037 0.4037
Loa Loa (eye worm) hypothetical protein 0.0029 0.3934 0.3934
Echinococcus multilocularis c src tyrosine kinase 0.0035 0.4971 0.4971
Entamoeba histolytica hypothetical protein 0.0029 0.4037 0.4037
Brugia malayi Guanylate kinase family protein 0.0029 0.4037 0.4037
Echinococcus multilocularis endophilin A3 0.0029 0.4037 0.4037
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0495 0.0546
Echinococcus granulosus c src tyrosine kinase 0.0035 0.4971 0.4971
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.3934 0.3618
Echinococcus granulosus fch and double sh3 domains protein 2 0.0029 0.4037 0.4037
Entamoeba histolytica hypothetical protein 0.0029 0.4037 0.4037
Trypanosoma brucei aurora B kinase 0.0064 1 1
Trichomonas vaginalis AGC family protein kinase 0.0064 1 1
Entamoeba histolytica BAR/SH3 domain containing protein 0.0029 0.4037 0.4037
Entamoeba histolytica hypothetical protein 0.0029 0.4037 0.4037
Schistosoma mansoni growth factor receptor-bound protein 0.0034 0.4766 0.4766
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0034 0.4766 0.4766
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0029 0.4037 0.4037
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0029 0.4037 0.4037
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.4037 0.3726
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0029 0.4037 0.4037
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Schistosoma mansoni eps8-related protein 0.0029 0.4037 0.4037
Entamoeba histolytica hypothetical protein, conserved 0.0029 0.4037 0.4037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.2703 0.6617
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0495 0.0546
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.2703 0.2323
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0035 0.4971 0.4971
Brugia malayi Variant SH3 domain containing protein 0.0029 0.4037 0.4037
Schistosoma mansoni dreadlocks/dock 0.0029 0.4037 0.4037
Echinococcus granulosus intersectin 2 0.0029 0.4037 0.4037
Loa Loa (eye worm) oxidoreductase 0.0008 0.0495 0.0495
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0029 0.4037 0.4037
Brugia malayi Variant SH3 domain containing protein 0.0029 0.4037 0.4037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.2703 0.6421
Schistosoma mansoni tyrosine kinase 0.0035 0.4971 0.4971
Onchocerca volvulus 0.0029 0.3934 0.9535
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0029 0.4037 0.4037
Entamoeba histolytica hypothetical protein 0.0029 0.4037 0.4037
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0035 0.4971 0.4971
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0495 0.0546
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.3934 1
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0029 0.4037 0.4037
Leishmania major protein kinase, putative 0.0064 1 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0495 0.0495
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.2505 0.6071
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0064 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.4971 0.4971
Entamoeba histolytica hypothetical protein, conserved 0.0029 0.4037 0.4037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.3934 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.4037 0.3726
Onchocerca volvulus 0.0029 0.4037 0.9783
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0495 0.0546
Loa Loa (eye worm) hypothetical protein 0.0021 0.2703 0.2703
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.4971 0.4971
Echinococcus granulosus nostrin 0.0029 0.4037 0.4037
Schistosoma mansoni tyrosine kinase 0.0035 0.4971 0.4971
Echinococcus granulosus epidermal growth factor receptor kinase 0.0029 0.4037 0.4037
Plasmodium falciparum serine/threonine protein kinase, putative 0.0064 1 1
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0029 0.4037 0.3726
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0495 0.0546
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0064 1 1
Brugia malayi Peripheral plasma membrane protein CASK 0.0029 0.4037 0.4037
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0495 0.0546
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0029 0.4037 0.4037
Entamoeba histolytica hypothetical protein 0.0029 0.4037 0.4037
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0035 0.4971 0.4971
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0029 0.4037 0.4037
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Entamoeba histolytica protein kinase, putative 0.0064 1 1
Entamoeba histolytica protein kinase, putative 0.0064 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0035 0.4971 0.4971
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.3934 1
Loa Loa (eye worm) p53BP2 0.0029 0.4037 0.4037
Mycobacterium ulcerans hypothetical protein 0.0029 0.3934 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0495 0.0495
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0035 0.4971 0.4971
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0495 0.0495
Brugia malayi AMP-binding enzyme family protein 0.0029 0.3934 0.3934
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0035 0.4971 0.4971
Loa Loa (eye worm) hypothetical protein 0.0021 0.2703 0.2703
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0029 0.4037 0.4037
Entamoeba histolytica hypothetical protein 0.0029 0.4037 0.4037
Onchocerca volvulus 0.0008 0.0495 0.12
Onchocerca volvulus 0.0008 0.0495 0.12
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.3934 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0495 0.0495
Brugia malayi Tyrosine-protein kinase abl-1 0.0035 0.4971 0.4971
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.3934 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.2505 0.6071
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0495 0.0546
Schistosoma mansoni hypothetical protein 0.0029 0.4037 0.4037
Onchocerca volvulus 0.0029 0.4037 0.9783
Loa Loa (eye worm) guanylate kinase 0.0029 0.4037 0.4037
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0034 0.4766 0.4766
Loa Loa (eye worm) thyroid receptor interactor 0.0029 0.4037 0.4037
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.4037 0.3726
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.3934 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.3934 0.3934
Echinococcus multilocularis nostrin 0.0029 0.4037 0.4037
Giardia lamblia Aurora kinase 0.0064 1 0.5
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0029 0.4037 0.4037
Echinococcus granulosus tyrosine protein kinase Src64B 0.0035 0.4971 0.4971
Schistosoma mansoni protein kinase 0.0064 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.3934 0.3934
Schistosoma mansoni dynamin-associated protein 0.0029 0.4037 0.4037
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.2703 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0495 0.0495
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0035 0.4971 0.4971
Entamoeba histolytica hypothetical protein 0.0029 0.4037 0.4037
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0495 0.0495
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0064 1 1
Schistosoma mansoni cell polarity protein 0.0029 0.4037 0.4037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.4971 0.4971
Brugia malayi serine/threonine kinase 12 0.0064 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Echinococcus multilocularis intersectin 2 0.0029 0.4037 0.4037
Echinococcus granulosus Spectrin alpha actinin 0.0029 0.4037 0.4037
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.4037 0.3726
Echinococcus granulosus aurora kinase A 0.0064 1 1
Echinococcus multilocularis Spectrin alpha actinin 0.0029 0.4037 0.4037
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0029 0.4037 0.4037
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.3934 0.3618
Trypanosoma brucei conserved protein 0.0029 0.4037 0.3726
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0029 0.4037 0.4037
Onchocerca volvulus 0.0029 0.4037 0.9783
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.3934 1
Brugia malayi Variant SH3 domain containing protein 0.0034 0.4766 0.4766
Trichomonas vaginalis p67phox protein, putative 0.0029 0.4037 0.3726
Onchocerca volvulus 0.0008 0.0495 0.12
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.4037 0.3726
Brugia malayi protein-tyrosine kinase 0.0029 0.4037 0.4037
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0029 0.4037 0.4037
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0495 0.0495
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0495 0.0495
Brugia malayi Fes/CIP4 homology domain containing protein 0.0029 0.4037 0.4037
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.4037 0.3726
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.3934 0.3618
Brugia malayi Variant SH3 domain containing protein 0.0034 0.4766 0.4766
Trichomonas vaginalis AGC family protein kinase 0.0064 1 1
Entamoeba histolytica protein kinase domain containing protein 0.0064 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.3934 0.3934
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.2505 0.6071
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Echinococcus granulosus tyrosine protein kinase Fyn 0.0035 0.4971 0.4971
Brugia malayi Variant SH3 domain containing protein 0.0029 0.4037 0.4037
Loa Loa (eye worm) hypothetical protein 0.0029 0.3934 0.3934
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0064 1 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0064 1 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0495 0.0546
Entamoeba histolytica protein kinase, putative 0.0029 0.4037 0.4037
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.4037 0.3726
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0495 0.0495
Schistosoma mansoni nck2/grb4 0.0034 0.4766 0.4766
Entamoeba histolytica BAR/SH3 domain containing protein 0.0029 0.4037 0.4037
Schistosoma mansoni tyrosine kinase 0.0035 0.4971 0.4971
Loa Loa (eye worm) hypothetical protein 0.0029 0.4037 0.4037
Echinococcus granulosus src region 0.0029 0.4037 0.4037
Loa Loa (eye worm) AUR protein kinase 0.0064 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0035 0.4971 0.4971
Schistosoma mansoni run and tbc1 domain containing 0.0029 0.4037 0.4037
Echinococcus granulosus growth factor receptor bound protein 2 0.0034 0.4766 0.4766
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0035 0.4971 0.4971
Loa Loa (eye worm) protein-tyrosine kinase 0.0029 0.4037 0.4037
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0029 0.4037 0.4037
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.3934 0.3934
Schistosoma mansoni Dab2-interacting protein-like 0.0029 0.4037 0.4037
Schistosoma mansoni serine/threonine protein kinase 0.0064 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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