Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1325 | 1 | 1 |
Onchocerca volvulus | 0.0199 | 0.0668 | 0.5 | |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0199 | 0.0668 | 0.0668 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1325 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1325 | 1 | 1 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0199 | 0.0668 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1325 | 1 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.1325 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 76.3 uM | Concentration of compoound required for inhibiting the binding of the fluorescent probe to the c-Src tyrosine kinase SH2 domain by 50% | ChEMBL. | 15163193 |
IC50 (binding) | = 76.3 uM | Concentration of compoound required for inhibiting the binding of the fluorescent probe to the c-Src tyrosine kinase SH2 domain by 50% | ChEMBL. | 15163193 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.