Detailed information for compound 175169

Basic information

Technical information
  • TDR Targets ID: 175169
  • Name: 5,7-dimethoxy-2-phenyl-2,3-dihydrochromen-4-o ne
  • MW: 284.307 | Formula: C17H16O4
  • H donors: 0 H acceptors: 1 LogP: 2.85 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2OC(CC(=O)c2c(c1)OC)c1ccccc1
  • InChi: 1S/C17H16O4/c1-19-12-8-15(20-2)17-13(18)10-14(21-16(17)9-12)11-6-4-3-5-7-11/h3-9,14H,10H2,1-2H3
  • InChiKey: IAFBOKYTDSDNHV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,7-dimethoxy-2-phenyl-chroman-4-one
  • 5,7-dimethoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
  • 5,7-dimethoxy-2-phenylchroman-4-one
  • 5,7-dimethoxy-2-phenyl-4-chromanone
  • 36052-66-1
  • 1036-72-2
  • Spectrum5_000466
  • Spectrum3_000587
  • 5,7-Dimethoxyflavanone
  • ST057643
  • KBio3_001534
  • KBioSS_000804
  • SpecPlus_000873
  • SPBio_001573
  • 5,7-Dimethoxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
  • 5,7-Dimethoxyflavanon
  • AIDS-142854
  • AIDS142854
  • NSC661206
  • 5,7-Dimethoxyflavonone
  • Spectrum_000324
  • KBioGR_002369
  • KBio2_000804
  • KBio2_003372
  • Spectrum2_001357
  • KBio2_005940
  • KBio1_001913
  • NCI60_021335
  • NCGC00142553-01
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dimethoxy-2-phenyl-
  • Flavanone, 5,7-dimethoxy-
  • Spectrum4_001873
  • BSPBio_002034
  • DivK1c_006969
  • ACon1_001227
  • MEGxp0_000558
  • NSC 661206

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium berghei ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium parvum ABC transporter, AAA domain Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ko:K05681 ATP-binding cassette, subfamily G (WHITE), member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi ABC transporter family protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Cryptosporidium hominis ABC transporter protein Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Plasmodium vivax ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter similar to S. cerevisiae YOL075C Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum ABC transporter G family member 2 Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani ATP-binding cassette protein subfamily G, member 4, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans multidrug resistance protein CDR1 originally isolated by ability to functionally substitute for S. cerevisiae PDR5 (YOR153W) ABC Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to N terminus of CaP19.6000 multidrug resistance transporter CDR1 Get druggable targets OG5_126574 All targets in OG5_126574
Schistosoma japonicum ATP-binding cassette sub-family G member 1, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans multidrug resistance ABC transporter similar to S. cerevisiae PDR5 (YOR153W) Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC transporter whose deletion does not affect fluconazole resistance Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans potential ABC family transporter similar to S. cerevisiae YNR070W Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma cruzi ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans N terminal 2/3 of Opaque-specific ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Echinococcus granulosus ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Leishmania mexicana ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ATP binding cassette sub family G Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi ABC transporter G family member 2, putative Get druggable targets OG5_126574 All targets in OG5_126574
Loa Loa (eye worm) ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Neospora caninum hypothetical protein Get druggable targets OG5_126574 All targets in OG5_126574
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter Get druggable targets OG5_126574 All targets in OG5_126574
Candida albicans identical to C terminus of nonallelic CaP19.919 Get druggable targets OG5_126574 All targets in OG5_126574
Trypanosoma brucei ATP-binding cassette protein, putative Get druggable targets OG5_126574 All targets in OG5_126574
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei ABC transporter, putative ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 611 aa 557 aa 28.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica zinc finger domain containing protein 0.0017 0.0068 0.4407
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0017 0.0068 0.0054
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0017 0.0068 0.0054
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0017 0.0068 0.0054
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0137 0.0091
Brugia malayi hypothetical protein 0.0017 0.0068 0.0022
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0137 0.0123
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Entamoeba histolytica hypothetical protein 0.0023 0.0137 1
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Plasmodium vivax trophozoite exported protein 1, putative 0.0017 0.0068 0.0054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Leishmania major cytochrome p450-like protein 0.0015 0.0046 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0068 0.0155
Echinococcus granulosus SWI:SNF matrix associated 0.0931 1 1
Giardia lamblia Kinase, NEK 0.0017 0.0068 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0017 0.0068 0.4407
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0017 0.0068 0.0054
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0017 0.0068 0.0054
Schistosoma mansoni brg-1 associated factor 0.0931 1 1
Brugia malayi Zinc finger protein 183 homolog 0.0017 0.0068 0.0022
Schistosoma mansoni TRABID protein (C64 family) 0.0331 0.3483 0.3474
Trypanosoma brucei DNA repair protein, putative 0.0017 0.0068 0.0155
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0017 0.0068 0.0054
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0017 0.0068 0.0155
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0137 0.0123
Onchocerca volvulus 0.0931 1 1
Brugia malayi Neuralized family protein 0.0017 0.0068 0.0022
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0017 0.0068 0.0155
Giardia lamblia Hypothetical protein 0.0017 0.0068 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0331 0.3483 1
Entamoeba histolytica SPRY domain protein 0.0017 0.0068 0.4407
Toxoplasma gondii helicase, putative 0.0017 0.0068 0.0054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Trypanosoma cruzi hypothetical protein, conserved 0.0331 0.3483 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Loa Loa (eye worm) hypothetical protein 0.0048 0.0406 0.0406
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Onchocerca volvulus 0.0331 0.3483 0.3438
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Giardia lamblia Hypothetical protein 0.0017 0.0068 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0331 0.3483 0.3453
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Toxoplasma gondii hypothetical protein 0.0017 0.0068 0.0054
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0331 0.3483 0.3474
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Giardia lamblia Hypothetical protein 0.0017 0.0068 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Leishmania major hypothetical protein, conserved 0.0331 0.3483 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0137 0.0123
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0137 0.0123
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0137 0.0123
Brugia malayi PXA domain containing protein 0.0023 0.0137 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0137 0.0069
Entamoeba histolytica zinc finger domain containing protein 0.0017 0.0068 0.4407
Echinococcus granulosus RING finger protein 185 0.0017 0.0068 0.0054
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0017 0.0068 0.0054
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0017 0.0068 0.0054
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0137 0.0069
Trypanosoma brucei ring finger containing protein 0.0017 0.0068 0.0155
Echinococcus granulosus zinc finger protein Ran binding 0.0331 0.3483 0.3474
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0017 0.0068 0.0054
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0137 0.0123
Loa Loa (eye worm) brahma associated protein 0.0931 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0331 0.3483 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.3483 0.3483
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0931 1 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0137 0.0091
Entamoeba histolytica zinc finger domain containing protein 0.0017 0.0068 0.4407
Schistosoma mansoni zinc finger protein 0.0017 0.0068 0.0054
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0137 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0331 0.3483 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0931 1 1
Brugia malayi RING finger protein 20 0.0017 0.0068 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0137 0.0123
Giardia lamblia Zinc finger domain 0.0017 0.0068 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0068 0.0155
Schistosoma mansoni fusion 0.0331 0.3483 0.3474
Brugia malayi RING zinc finger protein 0.0017 0.0068 0.0022
Echinococcus multilocularis 0.0017 0.0068 0.0054
Schistosoma mansoni hypothetical protein 0.0931 1 1
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.3483 0.3483
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0931 1 1
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.3483 0.3483
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0046 0.0046
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0017 0.0068 0.0054
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0137 0.0123
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0137 0.0137
Leishmania major hypothetical protein, conserved 0.0331 0.3483 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0931 1 1
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Toxoplasma gondii ran binding protein 0.0331 0.3483 0.3474
Brugia malayi PXA domain containing protein 0.0023 0.0137 0.0091
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0331 0.3483 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0406 0.0393
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0046 0.0093
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0331 0.3483 0.3453
Leishmania major DNA repair protein-like protein 0.0017 0.0068 0.0155
Brugia malayi hypothetical protein 0.0023 0.0137 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0068 0.0155
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0017 0.0068 0.0054
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0931 1 1
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Entamoeba histolytica zinc finger domain containing protein 0.0017 0.0068 0.4407
Schistosoma mansoni hypothetical protein 0.0331 0.3483 0.3474
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0331 0.3483 1
Giardia lamblia Hypothetical protein 0.0017 0.0068 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0137 0.0123
Brugia malayi B-box zinc finger family protein 0.0017 0.0068 0.0022
Brugia malayi SWIB/MDM2 domain containing protein 0.0931 1 1
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0331 0.3483 0.3438
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0017 0.0068 0.0054
Leishmania major hypothetical protein 0.0017 0.0068 0.0155
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Schistosoma mansoni hypothetical protein 0.0017 0.0068 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0137 0.0069
Echinococcus multilocularis RING finger protein 185 0.0017 0.0068 0.0054
Schistosoma mansoni mind bomb 0.0017 0.0068 0.0054
Loa Loa (eye worm) RING finger protein 20 0.0017 0.0068 0.0068
Giardia lamblia E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B 0.0017 0.0068 1
Trypanosoma cruzi hypothetical protein, conserved 0.0331 0.3483 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0331 0.3483 1
Plasmodium falciparum zinc finger protein, putative 0.0017 0.0068 0.0054
Trypanosoma cruzi WLM domain containing protein, putative 0.0331 0.3483 1
Onchocerca volvulus 0.0331 0.3483 0.3438
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0046 0.0093
Brugia malayi hypothetical protein 0.0017 0.0068 0.0022
Plasmodium falciparum trophozoite exported protein 1 0.0017 0.0068 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0137 0.0123
Leishmania major hypothetical protein, unknown function 0.0017 0.0068 0.0155
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Entamoeba histolytica zinc finger domain containing protein 0.0017 0.0068 0.4407
Echinococcus multilocularis SWI:SNF matrix associated 0.0931 1 1
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Schistosoma mansoni zinc finger protein 0.0331 0.3483 0.3474
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0137 0.0123
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Giardia lamblia Kinase, NEK 0.0017 0.0068 1
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0331 0.3483 0.3474
Trypanosoma brucei hypothetical protein, conserved 0.0331 0.3483 1
Schistosoma mansoni hypothetical protein 0.0931 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0137 0.0137
Plasmodium vivax zinc finger protein, putative 0.0017 0.0068 0.0054
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0331 0.3483 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0068 0.0155
Onchocerca volvulus 0.0331 0.3483 0.3438
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0017 0.0068 0.0054
Echinococcus granulosus tumor protein p63 0.0328 0.3446 0.3437
Entamoeba histolytica zinc finger domain containing protein 0.0017 0.0068 0.4407
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0137 0.0123
Echinococcus multilocularis ring finger protein 113a 0.0017 0.0068 0.0054
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0017 0.0068 0.0022
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0017 0.0068 0.0054
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0137 0.0123
Toxoplasma gondii hypothetical protein 0.0017 0.0068 0.0054
Leishmania major hypothetical protein, conserved 0.0331 0.3483 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0331 0.3483 0.3474
Entamoeba histolytica hypothetical protein 0.0017 0.0068 0.4407
Brugia malayi YY1-associated factor 2 0.0331 0.3483 0.3453
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0137 0.0123
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0137 0.0123
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0137 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0137 0.0069
Giardia lamblia Ser/Thr protein kinase 0.0017 0.0068 1
Echinococcus multilocularis zinc finger protein Ran binding 0.0331 0.3483 0.3474
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0137 0.0123
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0137 0.0123
Brugia malayi hypothetical protein 0.0017 0.0068 0.0022
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0137 0.0123
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0931 1 1
Giardia lamblia Kinase 0.0017 0.0068 1
Schistosoma mansoni hypothetical protein 0.0017 0.0068 0.0054
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0331 0.3483 0.3474
Trypanosoma brucei predicted zinc finger protein 0.0017 0.0068 0.0155
Chlamydia trachomatis SWIB complex protein 0.0931 1 0.5
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0017 0.0068 0.0054
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0017 0.0068 0.0155
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0017 0.0068 0.0054
Leishmania major hypothetical protein, conserved 0.0331 0.3483 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0137 0.0123
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0137 0.0123
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0046 0.0046
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0331 0.3483 0.3474
Giardia lamblia Hypothetical protein 0.0017 0.0068 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0068 0.0155
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Chlamydia trachomatis DNA topoisomerase I 0.0931 1 0.5
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0931 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Echinococcus multilocularis ring and YY1 binding protein 0.0331 0.3483 0.3474
Echinococcus granulosus ring and YY1 binding protein 0.0331 0.3483 0.3474
Entamoeba histolytica hypothetical protein 0.0023 0.0137 1
Plasmodium vivax DNA repair protein RAD5, putative 0.0017 0.0068 0.0054
Echinococcus multilocularis expressed protein 0.0451 0.4783 0.4775
Echinococcus granulosus expressed protein 0.0451 0.4783 0.4775
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0137 0.0069
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0931 1 1
Echinococcus multilocularis tumor protein p63 0.0328 0.3446 0.3437
Loa Loa (eye worm) hypothetical protein 0.0331 0.3483 0.3483
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0931 1 1
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0137 0.0123
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0137 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0068 0.0054
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Echinococcus granulosus cell growth regulator with ring finger domain 0.0017 0.0068 0.0054
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0017 0.0068 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0068 0.0155
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0017 0.0068 0.0054
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Brugia malayi Zinc finger, C2H2 type family protein 0.0017 0.0068 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0137 0.0069
Trypanosoma cruzi hypothetical protein 0.0017 0.0068 0.0155
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0137
Leishmania major hypothetical protein, conserved 0.0331 0.3483 1
Trypanosoma cruzi hypothetical protein 0.0017 0.0068 0.0155
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0137 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0137 0.0069
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0137 0.0123
Entamoeba histolytica hypothetical protein 0.0023 0.0137 1
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0017 0.0068 0.0054
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0137 0.0123
Schistosoma mansoni hypothetical protein 0.0931 1 1
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Echinococcus multilocularis ring finger protein 170 0.0017 0.0068 0.0054
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0017 0.0068 0.0054
Giardia lamblia Hypothetical protein 0.0017 0.0068 1
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0137 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0137 0.0123
Schistosoma mansoni RNA binding protein 0.0331 0.3483 0.3474
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0931 1 1
Toxoplasma gondii hypothetical protein 0.0017 0.0068 0.0054
Giardia lamblia Zinc finger domain 0.0017 0.0068 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Plasmodium falciparum RING zinc finger protein, putative 0.0017 0.0068 0.0054
Giardia lamblia Ribonuclease 0.0017 0.0068 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0137 0.0091
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Giardia lamblia Hypothetical protein 0.0017 0.0068 1
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Schistosoma mansoni rnf5 0.0017 0.0068 0.0054
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0137 0.0123
Entamoeba histolytica zinc finger domain containing protein 0.0017 0.0068 0.4407
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0137 0.0123
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Brugia malayi hypothetical protein 0.0023 0.0137 0.0091
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0331 0.3483 0.3453
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0137 0.0123
Brugia malayi hypothetical protein 0.0017 0.0068 0.0022
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0331 0.3483 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0068 0.0155
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Loa Loa (eye worm) RiNg Finger protein family member 0.0017 0.0068 0.0068
Brugia malayi hypothetical protein 0.0017 0.0068 0.0022
Toxoplasma gondii hypothetical protein 0.0017 0.0068 0.0054
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Toxoplasma gondii RING zinc finger protein 0.0017 0.0068 0.0054
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0046 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0137 0.0137
Brugia malayi brahma associated protein 60 kDa 0.0931 1 1
Schistosoma mansoni ring finger protein 151 0.0017 0.0068 0.0054
Echinococcus granulosus ring finger protein 170 0.0017 0.0068 0.0054
Onchocerca volvulus 0.0048 0.0406 0.034
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0331 0.3483 0.3453
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0137 0.0137
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0137 0.0091
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0331 0.3483 1
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0137 0.0123
Echinococcus granulosus ring finger protein 113a 0.0017 0.0068 0.0054
Leishmania major hypothetical protein, conserved 0.0017 0.0068 0.0155
Echinococcus granulosus Zinc finger RanBP2 type 0.0331 0.3483 0.3474
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Brugia malayi hypothetical protein 0.0017 0.0068 0.0022
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0017 0.0068 0.0054
Loa Loa (eye worm) hypothetical protein 0.0331 0.3483 0.3483
Schistosoma mansoni peter pan-related 0.0017 0.0068 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0068 0.0068
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0046 0.0093
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Entamoeba histolytica zinc finger domain containing protein 0.0017 0.0068 0.4407
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0137 0.0091
Plasmodium vivax RING zinc finger protein, putative 0.0017 0.0068 0.0054
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0931 1 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0068 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0331 0.3483 1
Onchocerca volvulus 0.0331 0.3483 0.3438
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0137 0.0123
Schistosoma mansoni peter pan-related 0.0017 0.0068 0.0054
Giardia lamblia Protein 21.1 0.0017 0.0068 1
Plasmodium vivax hypothetical protein, conserved 0.0931 1 1
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0017 0.0068 0.0054

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 17 uM Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining ChEMBL. 21354800
IC50 (binding) = 32 uM Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining ChEMBL. 21354800
IC50 (functional) = 33.06 uM Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay ChEMBL. 20362442
IC50 (functional) = 36 uM The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells ChEMBL. 11720850
IC50 (functional) = 36 uM The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells ChEMBL. 11720850
IC50 (functional) = 39.85 uM Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay ChEMBL. 20362442
Potency (functional) 5.3233 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.