Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0465 | 0.6852 | 0.5837 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Onchocerca volvulus | 0.0465 | 0.6852 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0465 | 0.6852 | 0.671 |
Onchocerca volvulus | 0.0465 | 0.6852 | 1 | |
Onchocerca volvulus | 0.0465 | 0.6852 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.3844 | 0.3565 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.062 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0465 | 0.6852 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0247 | 0.244 | 0.2097 |
Loa Loa (eye worm) | ctsf protein | 0.0465 | 0.6852 | 0.671 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0465 | 0.6852 | 0.6852 |
Echinococcus granulosus | cathepsin l1 | 0.0465 | 0.6852 | 0.5837 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0465 | 0.6852 | 0.6852 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0465 | 0.6852 | 0.671 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.062 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0465 | 0.6852 | 1 |
Echinococcus granulosus | cathepsin b | 0.062 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0465 | 0.6852 | 0.5837 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Leishmania major | cathepsin L-like protease | 0.0465 | 0.6852 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0465 | 0.6852 | 0.671 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Plasmodium vivax | unspecified product | 0.0247 | 0.244 | 0.3126 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0247 | 0.244 | 0.244 |
Trypanosoma cruzi | cysteine protease, putative | 0.0247 | 0.244 | 0.2097 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0465 | 0.6852 | 0.671 |
Echinococcus multilocularis | cathepsin b | 0.062 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0465 | 0.6852 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.026 | 0.27 | 0.0589 |
Echinococcus granulosus | cathepsin b | 0.062 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0465 | 0.6852 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0465 | 0.6852 | 0.5837 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0247 | 0.244 | 0.2097 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Plasmodium vivax | vivapain-3 | 0.0247 | 0.244 | 0.3126 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0316 | 0.3844 | 0.3182 |
Echinococcus multilocularis | cysteine protease | 0.0465 | 0.6852 | 0.5837 |
Brugia malayi | Cathepsin L-like precursor | 0.0465 | 0.6852 | 0.671 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0465 | 0.6852 | 0.671 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0247 | 0.244 | 0.2097 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 0.6852 | 0.671 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0465 | 0.6852 | 0.671 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0465 | 0.6852 | 0.671 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0465 | 0.6852 | 0.5837 |
Giardia lamblia | Cathepsin B precursor | 0.026 | 0.27 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0465 | 0.6852 | 0.5837 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0247 | 0.244 | 0.244 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0316 | 0.3844 | 0.3844 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0247 | 0.244 | 0.2097 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0247 | 0.244 | 0.244 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0465 | 0.6852 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0316 | 0.3844 | 0.3182 |
Schistosoma mansoni | cathepsin s | 0.0148 | 0.0433 | 0.0433 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0247 | 0.244 | 0.2097 |
Brugia malayi | Cathepsin L-like precursor | 0.0316 | 0.3844 | 0.3565 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0465 | 0.6852 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0465 | 0.6852 | 0.671 |
Brugia malayi | Cathepsin L-like precursor | 0.0316 | 0.3844 | 0.3565 |
Giardia lamblia | Cathepsin B precursor | 0.026 | 0.27 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0465 | 0.6852 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0465 | 0.6852 | 0.671 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.026 | 0.27 | 0.0589 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0316 | 0.3844 | 0.3565 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0465 | 0.6852 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0465 | 0.6852 | 0.5837 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.062 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.026 | 0.27 | 0.2369 |
Onchocerca volvulus | 0.0465 | 0.6852 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0316 | 0.3844 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Onchocerca volvulus | 0.0465 | 0.6852 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0465 | 0.6852 | 0.671 |
Echinococcus granulosus | cathepsin l1 | 0.0316 | 0.3844 | 0.1857 |
Brugia malayi | Cathepsin L-like precursor | 0.0465 | 0.6852 | 0.671 |
Brugia malayi | Cathepsin L-like precursor | 0.0465 | 0.6852 | 0.671 |
Brugia malayi | Cathepsin L-like precursor | 0.0465 | 0.6852 | 0.671 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0465 | 0.6852 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0316 | 0.3844 | 0.3565 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Leishmania major | cathepsin L-like protease | 0.0465 | 0.6852 | 1 |
Leishmania major | cathepsin L-like protease | 0.0465 | 0.6852 | 1 |
Plasmodium vivax | vivapain-2 | 0.0465 | 0.6852 | 1 |
Leishmania major | cathepsin L-like protease | 0.0465 | 0.6852 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.3844 | 0.3565 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.026 | 0.27 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0465 | 0.6852 | 0.671 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.026 | 0.27 | 0.27 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0247 | 0.244 | 0.2097 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.062 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0465 | 0.6852 | 1 |
Echinococcus multilocularis | cathepsin b | 0.062 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Leishmania major | cathepsin L-like protease | 0.0465 | 0.6852 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.026 | 0.27 | 0.2369 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0465 | 0.6852 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.3844 | 0.3565 |
Onchocerca volvulus | Cathepsin L homolog | 0.0465 | 0.6852 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0465 | 0.6852 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0465 | 0.6852 | 0.671 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.062 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0465 | 0.6852 | 0.5837 |
Leishmania major | cathepsin L-like protease | 0.0465 | 0.6852 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0316 | 0.3844 | 0.3565 |
Plasmodium vivax | vivapain-1 | 0.0247 | 0.244 | 0.3126 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Onchocerca volvulus | 0.0465 | 0.6852 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0465 | 0.6852 | 1 |
Onchocerca volvulus | 0.0465 | 0.6852 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of IFN-gamma-induced STAT1 (unknown origin) at 10 uM | ChEMBL. | 23434226 | |
Inhibition (binding) | = -20.4 % | Inhibition of IL-6-induced STAT3 pathway in human HepG2 cells at 10 uM by luciferase reporter gene assay | ChEMBL. | 23434226 |
Inhibition (functional) | = 38.78 % | Cytotoxicity against human MDA-MB-468 cells assessed as inhibition of cell viability at 10 uM | ChEMBL. | 23434226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.