TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.457 | Formula: C18H21N5OS
H donors: 2 H acceptors: 3 LogP: 2.68 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CC(c1csc(n1)Nc1nc(C)cnc1C)N
InChi: 1S/C18H21N5OS/c1-11-9-20-12(2)17(21-11)23-18-22-16(10-25-18)15(19)8-13-4-6-14(24-3)7-5-13/h4-7,9-10,15H,8,19H2,1-3H3,(H,21,22,23)
InChiKey: LEJHJDVPFQWTCQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0238	0.4989	0.8829
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0123	0.2081	0.2081
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	opsin-like receptor	0.0123	0.2081	0.2081
Onchocerca volvulus		0.0123	0.2081	0.2221
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	hypothetical protein	0.0123	0.2081	0.1911
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0123	0.2081	0.1911
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0123	0.2081	0.1911
Echinococcus multilocularis	g protein coupled receptor	0.0123	0.2081	0.1911
Trypanosoma cruzi	adenosine kinase, putative	0.0435	1	1
Echinococcus granulosus	equilibrative nucleoside transporter	0.0238	0.4989	0.4882
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.005	0.021	0.021
Echinococcus granulosus	allatostatin A receptor	0.0123	0.2081	0.1911
Echinococcus multilocularis	neuropeptide receptor	0.0123	0.2081	0.1911
Onchocerca volvulus		0.0123	0.2081	0.2221
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0264	0.5651	0.5651
Brugia malayi	AKH receptor	0.0123	0.2081	0.2081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0123	0.2081	0.1911
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	0.5651
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0264	0.5651	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus multilocularis	adenosine kinase	0.0435	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Onchocerca volvulus		0.0123	0.2081	0.2221
Loa Loa (eye worm)	TYRA-2 protein	0.0123	0.2081	0.2081
Leishmania major	tagatose-6-phosphate kinase-like protein	0.005	0.021	0.021
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.0264	0.5651	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0123	0.2081	0.1911
Brugia malayi	Serotonin receptor	0.0123	0.2081	0.2081
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0123	0.2081	0.1911
Schistosoma mansoni	amine GPCR	0.0123	0.2081	0.2081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.059	0.059
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0238	0.4989	0.5618
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0173	0.3341	0.5912
Brugia malayi	G-protein coupled receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.059	0.059
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0123	0.2081	0.2081
Schistosoma mansoni	opsin-like receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0264	0.5651	0.5558
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Brugia malayi	hypothetical protein	0.0238	0.4989	0.4989
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Brugia malayi	neuropeptide F receptor	0.0123	0.2081	0.2081
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Leishmania major	tagatose-6-phosphate kinase-like protein	0.005	0.021	0.021
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0123	0.2081	0.1911
Schistosoma mansoni	biogenic amine receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4989	0.4989
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.0264	0.5651	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	amine GPCR	0.0123	0.2081	0.2081
Brugia malayi	Serotonin receptor	0.0123	0.2081	0.2081
Trypanosoma cruzi	adenosine kinase, putative	0.005	0.021	0.021
Echinococcus multilocularis	allatostatin A receptor	0.0123	0.2081	0.1911
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	myosin xvIII	0.0123	0.2081	0.2081
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.0264	0.5651	0.5
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	tm gpcr rhodopsin	0.0123	0.2081	0.1911
Onchocerca volvulus		0.0386	0.8741	1
Echinococcus granulosus	g protein coupled receptor	0.0123	0.2081	0.1911
Onchocerca volvulus		0.0123	0.2081	0.2221
Echinococcus granulosus	neuropeptide receptor	0.0123	0.2081	0.1911
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	0.5651
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0082	0.1027	0.1027
Schistosoma mansoni	neuropeptide receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0123	0.2081	0.2081
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Toxoplasma gondii	kinase, pfkB family protein	0.005	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.059	0.059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Schistosoma mansoni	amine GPCR	0.0123	0.2081	0.2081
Onchocerca volvulus		0.0123	0.2081	0.2221
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Brugia malayi	Ribokinase	0.005	0.021	0.021
Echinococcus granulosus	neuropeptide receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0123	0.2081	0.1911
Brugia malayi	G-protein coupled receptor	0.0123	0.2081	0.2081
Brugia malayi	larval opioid receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus multilocularis	neuropeptide Y receptor	0.0123	0.2081	0.1911
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0091	0.1262	0.2233
Schistosoma mansoni	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	amine GPCR	0.0123	0.2081	0.2081
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0264	0.5651	0.5651
Echinococcus multilocularis	serotonin receptor	0.0123	0.2081	0.1911
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0082	0.1027	0.1027
Echinococcus granulosus	g-protein coupled receptor	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	tm gpcr rhodopsin	0.0123	0.2081	0.1911
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0238	0.4989	0.4882
Brugia malayi	sulfakinin receptor protein	0.0123	0.2081	0.2081
Brugia malayi	G protein-coupled receptor F59B2.13	0.0123	0.2081	0.2081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.059	0.059
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0123	0.2081	0.2081
Schistosoma mansoni	ribokinase	0.005	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0264	0.5651	0.5651
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0123	0.2081	0.1911
Echinococcus multilocularis	tumor protein p63	0.0331	0.7341	0.7284
Leishmania major	putative PfkB family sugar kinase	0.005	0.021	0.021
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0123	0.2081	0.2221
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.059	0.0388
Loa Loa (eye worm)	melatonin receptor type 1A	0.0123	0.2081	0.2081
Echinococcus multilocularis	serotonin receptor	0.0123	0.2081	0.1911
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	1
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0238	0.4989	0.8829
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0123	0.2081	0.2081
Echinococcus multilocularis	orexin receptor type 2	0.0123	0.2081	0.1911
Schistosoma mansoni	neuropeptide F-like receptor	0.0123	0.2081	0.2081
Entamoeba histolytica	Hypothetical protein T24C12.3, putative	0.005	0.021	0.0372
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0173	0.3341	0.3198
Schistosoma mansoni	amine GPCR	0.0123	0.2081	0.2081
Echinococcus multilocularis	neuropeptides capa receptor	0.0123	0.2081	0.1911
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.059	0.059
Brugia malayi	putative neuropeptide receptor	0.0123	0.2081	0.2081
Brugia malayi	putative neuropeptide receptor NPR1	0.0123	0.2081	0.2081
Echinococcus multilocularis	neuropeptides capa receptor	0.0123	0.2081	0.1911
Onchocerca volvulus		0.0123	0.2081	0.2221
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0173	0.3341	0.3341
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Onchocerca volvulus		0.0123	0.2081	0.2221
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	0.5651
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	neuropeptide Y receptor	0.0123	0.2081	0.1911
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0123	0.2081	0.2081
Brugia malayi	Dopamine receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	fmrfamide receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0123	0.2081	0.2081
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Echinococcus granulosus	equilibrative nucleoside transporter 3	0.0238	0.4989	0.4882
Trypanosoma cruzi	adenosine kinase, putative	0.0435	1	1
Echinococcus multilocularis	g protein coupled receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0123	0.2081	0.2081
Leishmania major	ribokinase, putative	0.005	0.021	0.021
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0238	0.4989	0.8829
Brugia malayi	RE15519p	0.0123	0.2081	0.2081
Brugia malayi	hypothetical protein	0.005	0.021	0.021
Entamoeba histolytica	nucleoside transporter, putative	0.0238	0.4989	0.8829
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0173	0.3337	0.3337
Schistosoma mansoni	neuropeptide F-like receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0173	0.3341	0.3198
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.059	0.1045
Schistosoma mansoni	adenoreceptor	0.0123	0.2081	0.2081
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.0264	0.5651	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0123	0.2081	0.2081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Brugia malayi	G protein-coupled receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	neuropeptide F receptor	0.0123	0.2081	0.2081
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0123	0.2081	0.2081
Echinococcus granulosus	neuropeptides capa receptor	0.0123	0.2081	0.1911
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0091	0.1265	1
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	1
Loa Loa (eye worm)	hypothetical protein	0.0173	0.3341	0.3341
Brugia malayi	ORL1-like opioid receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0264	0.5651	0.5558
Trypanosoma cruzi	adenosine kinase, putative	0.005	0.021	0.021
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	0.5651
Entamoeba histolytica	ribokinase, putative	0.005	0.021	0.0372
Schistosoma mansoni	neuropeptide receptor	0.0123	0.2081	0.2081
Onchocerca volvulus		0.0123	0.2081	0.2221
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0082	0.1027	0.1027
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0264	0.5651	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	adenosine kinase	0.0435	1	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Brugia malayi	Melatonin receptor type 1A	0.0123	0.2081	0.2081
Echinococcus granulosus	g protein coupled receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	growth hormone secretagogue receptor	0.0123	0.2081	0.2081
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.005	0.021	0.021
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Onchocerca volvulus		0.005	0.021	0.0036
Schistosoma mansoni	adenosine kinase	0.0435	1	1
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0264	0.5651	0.5651
Echinococcus multilocularis	g protein coupled receptor	0.0123	0.2081	0.1911
Echinococcus granulosus	adenosine kinase	0.0435	1	1
Echinococcus multilocularis	neuropeptide receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	hypothetical protein	0.0123	0.2081	0.2081
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0264	0.5651	0.5651
Schistosoma mansoni	neuropeptide receptor	0.0123	0.2081	0.2081
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0123	0.2081	0.1911
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0238	0.4989	0.8829
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0173	0.3337	0.5747
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0173	0.3337	0.3337
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0264	0.5651	0.5651
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0264	0.5651	1
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4989	0.4989
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.059	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Onchocerca volvulus		0.0123	0.2081	0.2221
Echinococcus multilocularis	g-protein coupled receptor	0.0123	0.2081	0.1911
Echinococcus multilocularis	neuropeptide Y receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	neuropeptide receptor	0.0123	0.2081	0.2081
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0082	0.1027	0.1027
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	1
Leishmania major	adenosine kinase-like protein	0.005	0.021	0.021
Schistosoma mansoni	hypothetical protein	0.0123	0.2081	0.2081
Onchocerca volvulus		0.0123	0.2081	0.2221
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0123	0.2081	0.2081
Schistosoma mansoni	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0123	0.2081	0.2081
Giardia lamblia	Hypothetical protein	0.0238	0.4989	0.8784
Onchocerca volvulus		0.0123	0.2081	0.2221
Trichomonas vaginalis	ribokinase, putative	0.005	0.021	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0123	0.2081	0.2081
Echinococcus multilocularis	sex peptide receptor	0.0123	0.2081	0.1911
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0123	0.2081	0.2081
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0435	1	1
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	orexin receptor type 2	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	dro:myosuppressin receptor	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Trypanosoma brucei	ribokinase, putative	0.005	0.021	0.021
Brugia malayi	follicle stimulating hormone receptor	0.0123	0.2081	0.2081
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0173	0.3341	0.5912
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.0264	0.5651	0.5651
Onchocerca volvulus		0.0123	0.2081	0.2221
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0264	0.5651	0.5651
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0173	0.3341	0.3341
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.0264	0.5651	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0123	0.2081	0.1911
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0264	0.5651	1
Echinococcus granulosus	somatostatin receptor	0.0123	0.2081	0.1911
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0264	0.5651	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.021	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0123	0.2081	0.2081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Echinococcus granulosus	neuropeptide receptor A26	0.0123	0.2081	0.1911
Schistosoma mansoni	biogenic amine receptor	0.0123	0.2081	0.2081
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0123	0.2081	0.2081
Trypanosoma brucei	ribokinase, putative	0.005	0.021	0.021
Entamoeba histolytica	tagatose-6-phosphate kinase, putative	0.005	0.021	0.0372
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0123	0.2081	0.1911
Trypanosoma brucei	adenosine kinase, putative	0.0435	1	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0082	0.1027	0.1027
Echinococcus multilocularis	neuropeptide receptor A26	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	G-protein coupled receptor	0.0123	0.2081	0.2081
Brugia malayi	Nucleoside transporter family protein	0.0238	0.4989	0.4989
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0091	0.1265	1
Onchocerca volvulus		0.0123	0.2081	0.2221
Trichomonas vaginalis	ribokinase, putative	0.005	0.021	0.0372
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0179	0.0179
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0238	0.4989	0.5618
Echinococcus multilocularis	equilibrative nucleoside transporter protein	0.0238	0.4989	0.4882
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Leishmania major	adenosine kinase, putative	0.0435	1	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Toxoplasma gondii	kinase, pfkB family protein	0.0435	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0123	0.2081	0.2081
Onchocerca volvulus		0.0123	0.2081	0.2221
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0182	0.3576	0.3576
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0123	0.2081	0.1911
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0123	0.2081	0.1911
Entamoeba histolytica	fructokinase, putative	0.005	0.021	0.0372
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0123	0.2081	0.2221
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Onchocerca volvulus		0.0123	0.2081	0.2221
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0197	0.3941	0.3811
Echinococcus granulosus	neuropeptide Y receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Echinococcus granulosus	g protein coupled receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0264	0.5651	0.5651
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.0264	0.5651	0.5651
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Loa Loa (eye worm)	neuropeptide F receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0123	0.2081	0.1911
Leishmania major	adenosine kinase-like protein	0.005	0.021	0.021
Trypanosoma cruzi	ribokinase, putative	0.005	0.021	0.021
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0082	0.1027	0.1027
Echinococcus multilocularis	fmrfamide receptor	0.0123	0.2081	0.1911
Echinococcus granulosus	neuropeptide FF receptor 2	0.0123	0.2081	0.1911
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.0264	0.5651	0.5
Brugia malayi	neuropeptide F receptor	0.0123	0.2081	0.2081
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Echinococcus multilocularis	fmrfamide receptor	0.0123	0.2081	0.1911
Schistosoma mansoni	histamine h1 receptor	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Trypanosoma brucei	adenosine kinase, putative	0.0435	1	1
Entamoeba histolytica	kinase, PfkB family	0.005	0.021	0.0372
Echinococcus granulosus	biogenic amine 5HT receptor	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	1
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0182	0.3576	0.3576
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0264	0.5651	0.5558
Echinococcus granulosus	biogenic amine 5HT receptor	0.0123	0.2081	0.1911
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0123	0.2081	0.1911
Echinococcus granulosus	tm gpcr rhodopsin	0.0123	0.2081	0.1911
Onchocerca volvulus	Ribokinase homolog	0.005	0.021	0.0036
Echinococcus granulosus	tumor protein p63	0.0331	0.7341	0.7284
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.059	0.059
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0091	0.1262	0.1262
Echinococcus granulosus	neuropeptides capa receptor	0.0123	0.2081	0.1911
Echinococcus multilocularis	dro:myosuppressin receptor	0.0123	0.2081	0.1911
Echinococcus granulosus	7tm_1 domain containing protein	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0238	0.4989	0.4989
Brugia malayi	Dopamine receptor protein 1	0.0123	0.2081	0.2081
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0264	0.5651	0.5651
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0264	0.5651	0.5651
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0173	0.3337	0.3337
Onchocerca volvulus		0.0123	0.2081	0.2221
Schistosoma mansoni	biogenic amine receptor	0.0123	0.2081	0.2081
Echinococcus multilocularis	neuropeptide s receptor	0.0123	0.2081	0.1911
Echinococcus granulosus	G protein coupled receptor 139	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Schistosoma mansoni	opsin-like receptor	0.0123	0.2081	0.2081
Schistosoma mansoni	neuropeptide f receptor 76f	0.0123	0.2081	0.2081
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0123	0.2081	0.2081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0123	0.2081	0.2081
Echinococcus granulosus	7TM GPCR rhodopsin	0.0123	0.2081	0.1911
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0264	0.5651	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Loa Loa (eye worm)	G-protein coupled receptor	0.0123	0.2081	0.2081
Trichomonas vaginalis	ribokinase, putative	0.005	0.021	0.0372
Brugia malayi	GnHR receptor homolog	0.0123	0.2081	0.2081
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0264	0.5651	0.5
Leishmania major	glyceraldehyde-3-phosphate dehydrogenase-like protein	0.0173	0.3337	0.3337
Echinococcus granulosus	sex peptide receptor	0.0123	0.2081	0.1911
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0264	0.5651	0.5558
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0264	0.5651	0.5651
Onchocerca volvulus		0.0123	0.2081	0.2221
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus multilocularis	somatostatin receptor	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	serotonin receptor	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0123	0.2081	0.1911
Loa Loa (eye worm)	hypothetical protein	0.0123	0.2081	0.2081
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.059	0.059
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0123	0.2081	0.1911
Onchocerca volvulus	Putative pyridoxal kinase	0.005	0.021	0.0036
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0123	0.2081	0.2081
Brugia malayi	hypothetical protein	0.0123	0.2081	0.2081
Echinococcus granulosus	rhodopsin orphan GPCR	0.0123	0.2081	0.1911
Brugia malayi	Dopamine receptor protein 2	0.0123	0.2081	0.2081
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0123	0.2081	0.1911

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2356251

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1756124