Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thioesterase | 0.0142 | 0.0074 | 0.4398 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0137 | 0.007 | 0.4155 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0171 | 0.0098 | 0.581 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0171 | 0.0098 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0137 | 0.007 | 0.4155 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.016 | 0.0088 | 0.0068 |
Mycobacterium ulcerans | polyketide synthase | 0.0181 | 0.0106 | 0.6337 |
Echinococcus granulosus | bifunctional protein NCOAT | 1.2055 | 1 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0113 | 0.0049 | 0.2941 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0255 | 0.0168 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0181 | 0.0106 | 0.6337 |
Schistosoma mansoni | Hyaluronidase | 1.2055 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.0194 | 0.0174 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0166 | 0.0093 | 0.5551 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0097 | 0.0036 | 0.2155 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0181 | 0.0106 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.014 | 0.0072 | 0.4267 |
Onchocerca volvulus | 0.0297 | 0.0203 | 0.9285 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0166 | 0.0093 | 0.5551 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0137 | 0.007 | 0.4155 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0171 | 0.0098 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0171 | 0.0098 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0123 | 0.0058 | 0.3424 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0171 | 0.0098 | 0.581 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0181 | 0.0106 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0035 | 0.0014 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0181 | 0.0106 | 0.6337 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0181 | 0.0106 | 0.6337 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0111 | 0.0048 | 0.2574 |
Mycobacterium ulcerans | polyketide synthase | 0.0171 | 0.0098 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0181 | 0.0106 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0255 | 0.0168 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.016 | 0.0088 | 0.5254 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0171 | 0.0098 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0255 | 0.0168 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0113 | 0.0049 | 0.2941 |
Mycobacterium ulcerans | thioesterase TesA | 0.0142 | 0.0074 | 0.4398 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0308 | 0.0212 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0181 | 0.0106 | 0.6337 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0255 | 0.0168 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0181 | 0.0106 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0122 | 0.0057 | 0.3708 |
Loa Loa (eye worm) | hypothetical protein | 0.5121 | 0.4223 | 0.4211 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0171 | 0.0098 | 0.0009 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0171 | 0.0098 | 0.581 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 1.2055 | 1 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0171 | 0.0098 | 0.581 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0142 | 0.0074 | 0.4398 |
Echinococcus multilocularis | bifunctional protein NCOAT | 1.2055 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0142 | 0.0074 | 0.4398 |
Loa Loa (eye worm) | hyaluronidase | 1.2055 | 1 | 1 |
Loa Loa (eye worm) | fatty acid synthase | 0.0169 | 0.0096 | 0.0075 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0069 | 0.0013 | 0.0765 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0181 | 0.0106 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0059 | 0.0004 | 0.0251 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0171 | 0.0098 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0113 | 0.0049 | 0.2941 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0324 | 0.0225 | 0.0138 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 100 % | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 25 uM after 18 hrs by CCK-8 assay | ChEMBL. | 23454014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.