Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 4 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 3 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Homo sapiens | chemokine (C-C motif) receptor 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | G-protein coupled receptor, putative | chemokine (C-X-C motif) receptor 4 | 356 aa | 332 aa | 20.2 % |
Brugia malayi | hypothetical protein | chemokine (C-C motif) receptor 1 | 355 aa | 289 aa | 21.8 % |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | chemokine (C-C motif) receptor 4 | 360 aa | 316 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 1.2153 | 1 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 1.2153 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5316 | 0.0612 | 0.0612 |
Schistosoma mansoni | Hyaluronidase | 1.2153 | 1 | 0.5 |
Loa Loa (eye worm) | hyaluronidase | 1.2153 | 1 | 1 |
Echinococcus multilocularis | bifunctional protein NCOAT | 1.2153 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5163 | 0.0401 | 0.0401 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 nM | Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand | ChEMBL. | 11720851 |
IC50 (binding) | = 13 nM | Binding affinity against C-C chemokine receptor type 5 stably expressed in Chinese hamster ovary (CHO) cells using [125I]-MIP-1 alpha as the radioligand | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-C chemokine receptor type 1 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-C chemokine receptor type 2 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-C chemokine receptor type 3 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-C chemokine receptor type 4 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-X-C chemokine receptor type 4 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-C chemokine receptor type 1 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-C chemokine receptor type 2 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-C chemokine receptor type 3 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-C chemokine receptor type 4 | ChEMBL. | 11720851 |
IC50 (binding) | > 1000 nM | Inhibitory activity against C-X-C chemokine receptor type 4 | ChEMBL. | 11720851 |
IC95 (functional) | = 25000 nM | Antiviral activity against HIV-1 viral replication in isolated peripheral blood mononuclear cells (PBMCs). | ChEMBL. | 11720851 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.