Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | spleen tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma mansoni | tyrosine kinase | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K05855 spleen tyrosine kinase, putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Schistosoma japonicum | ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Echinococcus multilocularis | tyrosine protein kinase shark | Get druggable targets OG5_131855 | All targets in OG5_131855 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclin D, putative | 0.0229 | 0.0109 | 0.539 |
Trypanosoma cruzi | cyclin, putative | 0.031 | 0.0203 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.871 | 1 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.031 | 0.0203 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.031 | 0.0203 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.37 | 0.4157 | 0.4036 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Echinococcus granulosus | cyclin B | 0.031 | 0.0203 | 0.0095 |
Schistosoma mansoni | cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.031 | 0.0203 | 1 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.871 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0264 | 0.015 | 0.0041 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.871 | 1 | 1 |
Plasmodium falciparum | cyclin | 0.0229 | 0.0109 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0229 | 0.0109 | 0.539 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 0.015 | 0.0041 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0229 | 0.0109 | 0.539 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0589 | 0.0529 | 0.0332 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.031 | 0.0203 | 0.5 |
Schistosoma mansoni | cyclin B | 0.031 | 0.0203 | 0.0095 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0264 | 0.015 | 0.0041 |
Schistosoma mansoni | tyrosine kinase | 0.0258 | 0.0143 | 0.0034 |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.031 | 0.0203 | 0.5 |
Trypanosoma brucei | mitotic cyclin 6 | 0.031 | 0.0203 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Onchocerca volvulus | 0.031 | 0.0203 | 0.5 | |
Trichomonas vaginalis | cyclins, putative | 0.031 | 0.0203 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.871 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0229 | 0.0109 | 0.539 |
Leishmania major | cyclin | 0.031 | 0.0203 | 0.5 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.031 | 0.0203 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0229 | 0.0109 | 0.539 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0589 | 0.0529 | 0.0424 |
Toxoplasma gondii | hypothetical protein | 0.0174 | 0.0045 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.031 | 0.0203 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0229 | 0.0109 | 0.539 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0589 | 0.0529 | 0.0332 |
Schistosoma mansoni | Hyaluronidase | 0.871 | 1 | 1 |
Echinococcus multilocularis | cyclin B | 0.031 | 0.0203 | 0.0095 |
Trichomonas vaginalis | cyclin A, putative | 0.031 | 0.0203 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 nM | Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis | ChEMBL. | 12941345 |
IC50 (binding) | = 100 nM | Inhibitory activity against human Syk protein tyrosine kinase expressed in yeast Klyveromyces lactis | ChEMBL. | 12941345 |
IC50 (binding) | = 100 nM | Inhibition of recombinant Syk | ChEMBL. | 19254842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.