Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Rattus norvegicus | Peripheral-type benzodiazepine receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.0248 | 0.0248 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 1.2076 | 1 | 1 |
Schistosoma mansoni | peripheral-type benzodiazepine receptor | 0.0322 | 0.0248 | 0.0248 |
Onchocerca volvulus | 0.0322 | 0.0248 | 1 | |
Onchocerca volvulus | 0.0322 | 0.0248 | 1 | |
Echinococcus multilocularis | translocator protein | 0.0322 | 0.0248 | 0.0248 |
Onchocerca volvulus | 0.0322 | 0.0248 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.0248 | 0.0248 |
Echinococcus multilocularis | bifunctional protein NCOAT | 1.2076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.0248 | 0.0248 |
Schistosoma mansoni | Hyaluronidase | 1.2076 | 1 | 1 |
Echinococcus granulosus | translocator protein | 0.0322 | 0.0248 | 0.0248 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.0248 | 0.0248 |
Brugia malayi | TspO/MBR family protein | 0.0322 | 0.0248 | 0.0248 |
Mycobacterium ulcerans | tryptophan-rich sensory protein | 0.0322 | 0.0248 | 0.5 |
Loa Loa (eye worm) | hyaluronidase | 1.2076 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.013 | 0.0089 | 0.0089 |
Onchocerca volvulus | 0.0322 | 0.0248 | 1 | |
Echinococcus granulosus | bifunctional protein NCOAT | 1.2076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.513 | 0.4237 | 0.4237 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(binding) | 0 | Manually curated assays from literature | Starlite. | 10508441 |
clogP | = 3.75 | Calculated partition coefficient (clogP) | ChEMBL. | 10508441 |
IC50 (binding) | = 5.47 | Affinty benzodiazepine receptor as ability to displace [3H]-flunitrazepam from binding to membrane preparations from rat cerebral cortex. | ChEMBL. | 10508441 |
IC50 (binding) | = 8.11 | Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes | ChEMBL. | 10508441 |
IC50 (binding) | = 8.12 | Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes | ChEMBL. | 10508441 |
IC50 (binding) | = 11.8 nM | Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor | ChEMBL. | 9301675 |
IC50 (binding) | = 11.8 nM | Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor | ChEMBL. | 9301675 |
IC50 (binding) | = 2740 nM | Displacement of [3H]-flunitrazepam from rat brain GABA-A Benzodiazepine receptor | ChEMBL. | 9301675 |
IC50 (binding) | = 2740 nM | Displacement of [3H]-flunitrazepam from rat brain GABA-A Benzodiazepine receptor | ChEMBL. | 9301675 |
Log IC50 (binding) | = 5.47 | Affinty benzodiazepine receptor as ability to displace [3H]-flunitrazepam from binding to membrane preparations from rat cerebral cortex. | ChEMBL. | 10508441 |
Log IC50 (binding) | = 8.11 | Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes | ChEMBL. | 10508441 |
Log IC50 (binding) | = 8.12 | Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes | ChEMBL. | 10508441 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.