Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Starlite/ChEMBL | References |
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | Starlite/ChEMBL | References |
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | Starlite/ChEMBL | References |
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | phosphatidylinositol 4-kinase alpha, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta | 582 aa | 491 aa | 25.2 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 1068 aa | 927 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0167 | 0.0103 |
Entamoeba histolytica | hypothetical protein | 0.0509 | 0.0476 | 0.7549 |
Echinococcus granulosus | phosphatidylinositol 45 bisphosphate 3 kinase | 0.0923 | 0.0986 | 0.0724 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0354 | 0.0284 | 1 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.8236 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0611 | 0.0601 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0353 | 0.0283 | 0.0193 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.8236 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0611 | 0.0601 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0197 | 0.0091 | 0.0498 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.8236 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0251 | 0.0158 | 0.1307 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0197 | 0.0091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3499 | 0.4161 | 0.4123 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0509 | 0.0476 | 0.7549 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0611 | 0.0601 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0923 | 0.0986 | 0.0724 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0589 | 0.0574 | 0.9475 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0923 | 0.0986 | 0.0904 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0455 | 0.0409 | 0.6242 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0822 | 0.0861 | 0.0802 |
Loa Loa (eye worm) | hyaluronidase | 0.8236 | 1 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0455 | 0.0409 | 0.6242 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0611 | 0.0601 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0611 | 0.0601 | 0.0515 |
Schistosoma mansoni | Hyaluronidase | 0.8236 | 1 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0611 | 0.0601 | 1 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0312 | 0.0233 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.0283 | 0.022 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0611 | 0.0601 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.016 uM | Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assay | ChEMBL. | 23726034 |
IC50 (binding) | = 0.1 uM | Inhibition of N-terminal myristoylated P110alpha (unknown origin)-mediated AKT phosphorylation at Ser473 expressed in rat Rat1 cells by ELISA | ChEMBL. | 23726034 |
IC50 (binding) | = 0.96 uM | Inhibition of P110delta (unknown origin) using PIP2:PS as substrate by TR-FRET assay | ChEMBL. | 23726034 |
IC50 (binding) | = 1.3 uM | Inhibition of N-terminal myristoylated P110delta (unknown origin)-mediated AKT phosphorylation at Ser473 expressed in rat Rat1 cells by ELISA | ChEMBL. | 23726034 |
IC50 (binding) | = 1.4 uM | Inhibition of P110gamma (unknown origin) using PIP2:PS as substrate by TR-FRET assay | ChEMBL. | 23726034 |
IC50 (binding) | = 4 uM | Inhibition of P110beta (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assay | ChEMBL. | 23726034 |
IC50 (binding) | = 5.9 uM | Inhibition of N-terminal myristoylated P110beta (unknown origin)-mediated AKT phosphorylation at Ser473 expressed in rat Rat1 cells by ELISA | ChEMBL. | 23726034 |
IC50 (ADMET) | > 10 uM | Inhibition of CYP3A4 (unknown origin) | ChEMBL. | 23726034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.