TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.289 | Formula: C10H10N6O4S
H donors: 3 H acceptors: 4 LogP: 0.86 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=S)N/N=C/1\CCNc2c1cc(cc2[N+](=O)[O-])[N+](=O)[O-]
InChi: 1S/C10H10N6O4S/c11-10(21)14-13-7-1-2-12-9-6(7)3-5(15(17)18)4-8(9)16(19)20/h3-4,12H,1-2H2,(H3,11,14,21)/b13-7+
InChiKey: XTTIIOBHBBXUNL-NTUHNPAUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0274	0.0274
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.086	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.0184	0.0184
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0184	0.0184
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0274	0.0274
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.086	0.086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0274	0.0092
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Brugia malayi	cathepsin L-like precursor	0.0023	0.0274	0.0274
Schistosoma mansoni	hypothetical protein	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.0184	0.0184
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0184	0.0184
Brugia malayi	putative neuropeptide receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0274	0.1018
Schistosoma mansoni	hypothetical protein	0.0022	0.0184	0.0184
Echinococcus granulosus	fmrfamide receptor	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Toxoplasma gondii	cathepsin B	0.006	0.2688	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus multilocularis	sex peptide receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	hypothetical protein	0.0022	0.0184	0.0184
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0274	0.1018
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	hypothetical protein	0.0022	0.0184	0.0184
Echinococcus multilocularis	cysteine protease	0.0032	0.086	0.086
Schistosoma mansoni	opsin-like receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.0184	0.0184
Echinococcus granulosus	orexin receptor type 2	0.0022	0.0184	0.0184
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0184	0.0184
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0184	0.0184
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Brugia malayi	G-protein coupled receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.0184	0.0184
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0184	0.0184
Echinococcus granulosus	cathepsin b	0.0171	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.0184	0.0184
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Brugia malayi	AKH receptor	0.0022	0.0184	0.0184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.0184	0.0184
Onchocerca volvulus		0.0032	0.086	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.0184	0.0184
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0184	0.0184
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.086	0.086
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0032	0.086	0.0689
Brugia malayi	RE15519p	0.0022	0.0184	0.0184
Brugia malayi	ORL1-like opioid receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0184	0.0184
Echinococcus multilocularis	somatostatin receptor	0.0022	0.0184	0.0184
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.086	0.086
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.0184	0.0184
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.086	0.086
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.086	1
Echinococcus multilocularis	serotonin receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0184	0.0184
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.2688	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.2688	0.2688
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Loa Loa (eye worm)	fibroinase	0.0032	0.086	0.0689
Echinococcus granulosus	sex peptide receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.086	0.086
Brugia malayi	neuropeptide F receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	cathepsin l1	0.0032	0.086	0.086
Echinococcus granulosus	allatostatin A receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	serotonin receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.0184	0.0184
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.086	0.0689
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	opsin-like receptor	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.0184	0.0184
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.2688	0.2688
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.086	0.086
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0184	0.0184
Onchocerca volvulus		0.0032	0.086	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.0184	0.0184
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.2688	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.0184	0.0184
Brugia malayi	Serotonin receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0184	0.0184
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.0184	0.0184
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	cysteine protease	0.0032	0.086	0.086
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.086	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0274	0.0274
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0171	1	1
Echinococcus granulosus	somatostatin receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.0184	0.0184
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	amine GPCR	0.0022	0.0184	0.0184
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0184	0.0184
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.086	0.0689
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.086	0.086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.086	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	1	1
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0184	0.0184
Onchocerca volvulus		0.0032	0.086	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0184	0.0184
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.0184	0.0184
Onchocerca volvulus		0.0032	0.086	1
Onchocerca volvulus		0.0023	0.0274	0.1331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Brugia malayi	larval opioid receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0274	0.0092
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0274	0.0274
Plasmodium vivax	vivapain-2	0.0032	0.086	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.0184	0.0184
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0274	0.0092
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.0184	0.0184
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	amine GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.086	1
Onchocerca volvulus		0.0032	0.086	1
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.0184	0.0184
Brugia malayi	follicle stimulating hormone receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.086	0.086
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	cathepsin l1	0.0023	0.0274	0.0274
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0184	0.0184
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Echinococcus granulosus	cathepsin b	0.0171	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.0184	0.0184
Schistosoma mansoni	opsin-like receptor	0.0022	0.0184	0.0184
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Brugia malayi	Dopamine receptor protein 2	0.0022	0.0184	0.0184
Brugia malayi	sulfakinin receptor protein	0.0022	0.0184	0.0184
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus granulosus	hypothetical protein	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.086	0.3201
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.0184	0.0184
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.086	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.0184	0.0184
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Giardia lamblia	Cathepsin B precursor	0.006	0.2688	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.0184	0.0184
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.0184	0.0184
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.086	1
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0274	0.3182
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Onchocerca volvulus		0.0032	0.086	1
Onchocerca volvulus		0.0032	0.086	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0184	0.0184
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0184	0.0184
Loa Loa (eye worm)	cathepsin B	0.006	0.2688	0.2551
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.086	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.0184	0.0184
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0184	0.0184
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0184	0.0184
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.086	1
Echinococcus granulosus	serotonin receptor	0.0022	0.0184	0.0184
Brugia malayi	G protein-coupled receptor	0.0022	0.0184	0.0184
Brugia malayi	GnHR receptor homolog	0.0022	0.0184	0.0184
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Schistosoma mansoni	histamine h1 receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	1	1
Schistosoma mansoni	amine GPCR	0.0022	0.0184	0.0184
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.086	0.3201
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.086	0.086
Entamoeba histolytica	cysteine protease, putative	0.0032	0.086	1
Schistosoma mansoni	myosin xvIII	0.0022	0.0184	0.0184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0184	0.0184
Loa Loa (eye worm)	ctsf protein	0.0032	0.086	0.0689
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0274	0.0274
Brugia malayi	Cathepsin L-like precursor	0.0032	0.086	0.086
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.0184	0.0184
Brugia malayi	Dopamine receptor protein 1	0.0022	0.0184	0.0184
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	amine GPCR	0.0022	0.0184	0.0184
Loa Loa (eye worm)	cysteine protease	0.0032	0.086	0.0689
Plasmodium vivax	vivapain-2	0.0032	0.086	1
Brugia malayi	neuropeptide F receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.0184	0.0184
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.2688	1
Brugia malayi	Dopamine receptor	0.0022	0.0184	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.086	0.3201
Brugia malayi	Serotonin receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.0184	0.0184
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Brugia malayi	G-protein coupled receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0184	0.0184
Brugia malayi	Melatonin receptor type 1A	0.0022	0.0184	0.0184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0184	0.0184
Schistosoma mansoni	amine GPCR	0.0022	0.0184	0.0184
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.086	0.086
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0184	0.0184
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.0184	0.0184
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0184	0.0184
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.0184	0.0184
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.0184	0.0184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.086	0.3201
Schistosoma mansoni	adenoreceptor	0.0022	0.0184	0.0184
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Brugia malayi	hypothetical protein	0.0022	0.0184	0.0184

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 338 nM	Inhibition of human liver Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorometric analysis	ChEMBL.	23540644
IC50 (binding)	> 10000 nM	Inhibition of human liver Cathepsin B using Z-Arg-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorometric analysis	ChEMBL.	23540644

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2376004

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1764264