Detailed information for compound 1764281

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.332 | Formula: C12H15N3OS
  • H donors: 2 H acceptors: 0 LogP: 1.81 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)/C(=N/NC(=S)N)/CCC2
  • InChi: 1S/C12H15N3OS/c1-16-9-6-5-8-3-2-4-11(10(8)7-9)14-15-12(13)17/h5-7H,2-4H2,1H3,(H3,13,15,17)/b14-11+
  • InChiKey: NGIIRWGCDGUKFT-SDNWHVSQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0067 0.3136 0.3136
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein kinase Srms 0.0067 0.3136 0.3136
Brugia malayi SH2 domain containing protein 0.0047 0.1814 0.1814
Onchocerca volvulus 0.0047 0.1814 0.5784
Echinococcus multilocularis SH2 motif 0.0047 0.1814 0.1814
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0047 0.1814 0.1814
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0795 0.0795
Onchocerca volvulus 0.0032 0.0795 0.2534
Onchocerca volvulus 0.0032 0.0795 0.2534
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0067 0.3136 0.3136
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0047 0.1814 0.1814
Echinococcus multilocularis 0.0047 0.1814 0.1814
Brugia malayi STAT protein, DNA binding domain containing protein 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0067 0.3136 0.3136
Brugia malayi SH2 domain containing protein 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein kinase shark 0.0067 0.3136 0.3136
Echinococcus multilocularis growth factor receptor bound protein 2 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Loa Loa (eye worm) SH2 domain-containing protein 0.0047 0.1814 0.1814
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0795 0.0795
Echinococcus multilocularis c src tyrosine kinase 0.0067 0.3136 0.3136
Echinococcus granulosus NCK adaptor protein 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Echinococcus granulosus tyrosine kinase 0.0067 0.3136 0.3136
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Giardia lamblia Cathepsin B precursor 0.006 0.2635 1
Loa Loa (eye worm) cysteine protease 0.0032 0.0795 0.0795
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Brugia malayi hypothetical protein 0.0067 0.3136 0.3136
Schistosoma mansoni tensin-related 0.0047 0.1814 0.1814
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0067 0.3136 0.3136
Onchocerca volvulus 0.0032 0.0795 0.2534
Echinococcus multilocularis SHC transforming protein 3 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Echinococcus granulosus tyrosine protein kinase Fyn 0.0067 0.3136 0.3136
Schistosoma mansoni nck2/grb4 0.0047 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0067 0.3136 0.3136
Echinococcus granulosus cathepsin l1 0.0032 0.0795 0.0795
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.0204
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.1814 0.1814
Loa Loa (eye worm) cathepsin B 0.006 0.2635 0.2635
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0795 0.3016
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Leishmania major cathepsin L-like protease 0.0032 0.0795 0.3016
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0795 0.0795
Echinococcus granulosus cathepsin l1 0.0023 0.0204 0.0204
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0047 0.1814 0.1814
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0795 0.2534
Entamoeba histolytica SH2 domain containing protein 0.0047 0.1814 0.5784
Schistosoma mansoni tensin-related 0.0047 0.1814 0.1814
Plasmodium vivax vivapain-2 0.0032 0.0795 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0047 0.1814 0.1814
Echinococcus multilocularis tensin 0.0047 0.1814 0.1814
Onchocerca volvulus Cathepsin F homolog 0.0032 0.0795 0.2534
Onchocerca volvulus 0.0047 0.1814 0.5784
Schistosoma mansoni adapter molecule crk 0.0047 0.1814 0.1814
Brugia malayi SH2 domain containing protein 0.0047 0.1814 0.1814
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0047 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Schistosoma mansoni SH2A 0.0047 0.1814 0.1814
Echinococcus granulosus SH2 motif 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Echinococcus multilocularis cathepsin b 0.0171 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0047 0.1814 0.1814
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0795 0.2534
Schistosoma mansoni hypothetical protein 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0204 0.0774
Brugia malayi SH2 domain containing protein 0.0067 0.3136 0.3136
Brugia malayi Variant SH3 domain containing protein 0.0047 0.1814 0.1814
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0067 0.3136 1
Schistosoma mansoni tensin 0.0047 0.1814 0.1814
Onchocerca volvulus 0.0067 0.3136 1
Onchocerca volvulus 0.0032 0.0795 0.2534
Echinococcus multilocularis tyrosine protein kinase Blk 0.0067 0.3136 0.3136
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0795 0.0795
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0204 0.0204
Echinococcus granulosus tyrosine protein kinase Src64B 0.0067 0.3136 0.3136
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0047 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0171 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0067 0.3136 0.3136
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0795 0.3016
Leishmania major cathepsin L-like protease 0.0032 0.0795 0.3016
Schistosoma mansoni GTPase activating protein 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0067 0.3136 0.3136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0795 0.0795
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.0795 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Schistosoma mansoni shc transforming protein 0.0047 0.1814 0.1814
Brugia malayi Sex muscle abnormal protein 5 0.0047 0.1814 0.1814
Schistosoma mansoni suppressor of cytokine signaling 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Brugia malayi Cathepsin L-like precursor 0.0032 0.0795 0.0795
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0795 0.2534
Echinococcus granulosus signal transduction protein lnk realted 0.0047 0.1814 0.1814
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0204 0.0204
Loa Loa (eye worm) SRC-1 0.0067 0.3136 0.3136
Leishmania major cathepsin L-like protease 0.0032 0.0795 0.3016
Leishmania major cathepsin L-like protease 0.0032 0.0795 0.3016
Onchocerca volvulus 0.0067 0.3136 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0067 0.3136 0.3136
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.0795 0.0795
Brugia malayi SH2 domain containing protein 0.0047 0.1814 0.1814
Echinococcus granulosus hypothetical protein 0.0047 0.1814 0.1814
Brugia malayi RhoGAP domain containing protein 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0067 0.3136 0.3136
Echinococcus multilocularis SH2 domain containing protein 7 0.0047 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.0204
Schistosoma mansoni tensin 0.0047 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Toxoplasma gondii cathepsin CPL 0.0032 0.0795 0.3016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0795 0.0795
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.2635 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0067 0.3136 0.3136
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0067 0.3136 0.3136
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.0204 0.0204
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0047 0.1814 0.1814
Onchocerca volvulus 0.0047 0.1814 0.5784
Echinococcus granulosus cathepsin b 0.0171 1 1
Brugia malayi Cathepsin L-like precursor 0.0032 0.0795 0.0795
Echinococcus granulosus tyrosine protein kinase Fyn 0.0067 0.3136 0.3136
Loa Loa (eye worm) ctsf protein 0.0032 0.0795 0.0795
Echinococcus multilocularis tensin 0.0047 0.1814 0.1814
Loa Loa (eye worm) TK/ABL protein kinase 0.0067 0.3136 0.3136
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0067 0.3136 0.3136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Brugia malayi Cathepsin L-like precursor 0.0032 0.0795 0.0795
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0047 0.1814 0.1814
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Leishmania major cysteine peptidase A (CPA) 0.0032 0.0795 0.3016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0795 0.0795
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Echinococcus multilocularis cysteine protease 0.0032 0.0795 0.0795
Brugia malayi Variant SH3 domain containing protein 0.0047 0.1814 0.1814
Echinococcus granulosus cathepsin b 0.0171 1 1
Schistosoma mansoni tyrosine kinase 0.0067 0.3136 0.3136
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Onchocerca volvulus 0.0032 0.0795 0.2534
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Echinococcus granulosus tyrosine kinase 0.0067 0.3136 0.3136
Echinococcus granulosus tyrosine protein kinase Srms 0.0067 0.3136 0.3136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.0795 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0067 0.3136 0.3136
Schistosoma mansoni growth factor receptor-bound protein 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Onchocerca volvulus 0.0067 0.3136 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0047 0.1814 0.5784
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.0795 0.0795
Onchocerca volvulus 0.0067 0.3136 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.0795 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.2635 0.2635
Plasmodium vivax vivapain-2 0.0032 0.0795 1
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0795 0.0795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0047 0.1814 0.1814
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0795 0.0795
Brugia malayi SH2 domain containing protein 0.0067 0.3136 0.3136
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Brugia malayi Cathepsin L-like precursor 0.0032 0.0795 0.0795
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 1 1
Leishmania major cathepsin L-like protease 0.0032 0.0795 0.3016
Echinococcus granulosus SH2 motif 0.0047 0.1814 0.1814
Leishmania major cathepsin L-like protease 0.0032 0.0795 0.3016
Leishmania major cathepsin L-like protease 0.0032 0.0795 0.3016
Echinococcus granulosus SH2 domain containing protein 7 0.0047 0.1814 0.1814
Echinococcus multilocularis cysteine protease 0.0032 0.0795 0.0795
Echinococcus granulosus tyrosine protein kinase Src42A 0.0067 0.3136 0.3136
Brugia malayi Cathepsin L-like precursor 0.0023 0.0204 0.0204
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0047 0.1814 0.1814
Brugia malayi Cathepsin L-like precursor 0.0032 0.0795 0.0795
Brugia malayi Cathepsin L-like precursor 0.0032 0.0795 0.0795
Brugia malayi cytokine inducible SH2-containing protein 5 0.0047 0.1814 0.1814
Onchocerca volvulus 0.0032 0.0795 0.2534
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0067 0.3136 0.3136
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0047 0.1814 0.5784
Brugia malayi Variant SH3 domain containing protein 0.0047 0.1814 0.1814
Schistosoma mansoni tyrosine kinase 0.0067 0.3136 0.3136
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0067 0.3136 0.3136
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Schistosoma mansoni tyrosine kinase 0.0067 0.3136 0.3136
Echinococcus multilocularis tyrosine protein kinase Abl 0.0067 0.3136 0.3136
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0047 0.1814 0.1814
Schistosoma mansoni tensin 0.0047 0.1814 0.1814
Entamoeba histolytica protein kinase, putative 0.0047 0.1814 0.5784
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0047 0.1814 0.1814
Schistosoma mansoni hypothetical protein 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0067 0.3136 0.3136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.0204
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0795 0.0795
Brugia malayi Cathepsin L-like precursor 0.0023 0.0204 0.0204
Echinococcus multilocularis SH2 motif 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine kinase 0.0067 0.3136 0.3136
Brugia malayi protein-tyrosine kinase 0.0067 0.3136 0.3136
Leishmania major cathepsin L-like protease 0.0032 0.0795 0.3016
Onchocerca volvulus 0.0047 0.1814 0.5784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Brugia malayi tRNA modification GTPase TrmE family protein 0.0047 0.1814 0.1814
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.2635 0.2635
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Brugia malayi Protein kinase domain containing protein 0.0067 0.3136 0.3136
Brugia malayi SRC-1 0.0067 0.3136 0.3136
Toxoplasma gondii cathepsin B 0.006 0.2635 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.1814 0.1814
Schistosoma mansoni vav2 0.0047 0.1814 0.1814
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Brugia malayi Tyrosine-protein kinase abl-1 0.0067 0.3136 0.3136
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0047 0.1814 0.1814
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0047 0.1814 0.5784
Echinococcus granulosus tyrosine protein kinase Lyn 0.0067 0.3136 0.3136
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0795 0.0795
Echinococcus granulosus suppressor of cytokine signaling 7 0.0047 0.1814 0.1814
Echinococcus multilocularis N chimaerin 0.0047 0.1814 0.1814
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0795 0.0795
Brugia malayi Protein kinase domain containing protein 0.0067 0.3136 0.3136
Loa Loa (eye worm) STAT protein 0.0047 0.1814 0.1814
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.0795 0.0795
Giardia lamblia Cathepsin B precursor 0.006 0.2635 1
Schistosoma mansoni suppressor of cytokine signaling 0.0047 0.1814 0.1814
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.0795 0.0795
Echinococcus multilocularis cathepsin b 0.0171 1 1
Brugia malayi Protein kinase domain containing protein 0.0067 0.3136 0.3136
Schistosoma mansoni growth factor receptor-bound protein 0.0047 0.1814 0.1814
Schistosoma mansoni tyrosine kinase 0.0067 0.3136 0.3136
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.2635 1
Onchocerca volvulus 0.0032 0.0795 0.2534
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0067 0.3136 0.3136
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0204 0.065
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0047 0.1814 0.1814
Brugia malayi Protein kinase domain containing protein 0.0067 0.3136 0.3136
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0067 0.3136 0.3136
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0047 0.1814 0.1814
Echinococcus granulosus SH2 domain containing adapter protein F 0.0047 0.1814 0.1814
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Echinococcus multilocularis SH2 motif 0.0047 0.1814 0.1814
Echinococcus granulosus tensin 0.0047 0.1814 0.1814
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0067 0.3136 0.3136
Brugia malayi SH2 domain containing protein 0.0047 0.1814 0.1814
Echinococcus granulosus SHC transforming protein 3 0.0047 0.1814 0.1814
Brugia malayi Tensin 0.0047 0.1814 0.1814
Echinococcus granulosus N chimaerin 0.0047 0.1814 0.1814
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.2635 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0067 0.3136 0.3136
Schistosoma mansoni signal transduction protein lnk-related 0.0047 0.1814 0.1814
Schistosoma mansoni tyrosine kinase 0.0067 0.3136 0.3136
Onchocerca volvulus 0.0047 0.1814 0.5784
Echinococcus granulosus tyrosine protein kinase Blk 0.0067 0.3136 0.3136
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Onchocerca volvulus 0.0023 0.0204 0.065
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0067 0.3136 0.3136
Echinococcus granulosus tyrosine protein kinase Src42A 0.0047 0.1814 0.1814
Echinococcus granulosus expressed conserved protein 0.0047 0.1814 0.1814
Echinococcus granulosus tyrosine protein kinase Fyn 0.0067 0.3136 0.3136
Loa Loa (eye worm) hypothetical protein 0.0047 0.1814 0.1814
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0795 0.2534
Echinococcus granulosus tyrosine protein kinase shark 0.0067 0.3136 0.3136
Loa Loa (eye worm) SH2 domain-containing protein 0.0047 0.1814 0.1814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0795 0.3016
Brugia malayi SH2 domain containing protein 0.0047 0.1814 0.1814
Echinococcus granulosus tyrosine protein kinase ABL1 0.0067 0.3136 0.3136
Giardia lamblia Cathepsin B precursor 0.006 0.2635 1
Brugia malayi Variant SH3 domain containing protein 0.0047 0.1814 0.1814
Schistosoma mansoni tyrosine kinase 0.0067 0.3136 0.3136
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0795 0.0795
Echinococcus multilocularis NCK adaptor protein 0.0047 0.1814 0.1814
Loa Loa (eye worm) fibroinase 0.0032 0.0795 0.0795
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.1814 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Brugia malayi cathepsin L-like precursor 0.0023 0.0204 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0795 0.3016
Onchocerca volvulus 0.0067 0.3136 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0204 0.0774
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0047 0.1814 0.1814
Entamoeba histolytica cysteine protease, putative 0.0032 0.0795 0.2534
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0795 0.3016
Loa Loa (eye worm) TK protein kinase 0.0067 0.3136 0.3136
Onchocerca volvulus 0.0047 0.1814 0.5784
Onchocerca volvulus 0.0067 0.3136 1
Loa Loa (eye worm) TK/FER protein kinase 0.0067 0.3136 0.3136
Echinococcus granulosus growth factor receptor bound protein 2 0.0047 0.1814 0.1814
Loa Loa (eye worm) SH2 domain-containing protein 0.0047 0.1814 0.1814
Echinococcus multilocularis signal transduction protein lnk realted 0.0047 0.1814 0.1814
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0047 0.1814 0.1814
Echinococcus granulosus c src tyrosine kinase 0.0067 0.3136 0.3136
Brugia malayi hypothetical protein 0.0047 0.1814 0.1814
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.1814 0.1814
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0047 0.1814 0.1814
Brugia malayi SH2 domain containing protein 0.0047 0.1814 0.1814

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Inhibition of human liver Cathepsin B using Z-Arg-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorometric analysis ChEMBL. 23540644
IC50 (binding) > 10000 nM Inhibition of human liver Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by fluorometric analysis ChEMBL. 23540644

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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