Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | sema domain-containing protein | 0.0024 | 0.1462 | 0.0354 |
Onchocerca volvulus | 0.0058 | 0.7957 | 1 | |
Leishmania major | pyruvate kinase | 0.0032 | 0.3035 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.3035 | 0.3035 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0032 | 0.3035 | 0.1843 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3295 | 0.2425 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.3035 | 0.2422 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3035 | 0.2132 |
Echinococcus granulosus | semaphorin 1A | 0.0024 | 0.1462 | 0.1462 |
Chlamydia trachomatis | pyruvate kinase | 0.0032 | 0.3035 | 0.5 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.3035 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.3035 | 0.3814 |
Schistosoma mansoni | plexin | 0.0058 | 0.7957 | 1 |
Echinococcus multilocularis | hypothetical protein | 0.0024 | 0.1462 | 0.1462 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.3035 | 0.5 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.1148 | 0.5 |
Echinococcus multilocularis | plexin a4 | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.3035 | 0.2132 |
Leishmania major | pyruvate kinase | 0.0032 | 0.3035 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0032 | 0.3035 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0032 | 0.3035 | 0.5 |
Brugia malayi | Plexin repeat family protein | 0.0058 | 0.7957 | 0.7608 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.3035 | 0.3035 |
Giardia lamblia | Pyruvate kinase | 0.0032 | 0.3035 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0032 | 0.3035 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.3035 | 0.2422 |
Echinococcus granulosus | pyruvate kinase | 0.0032 | 0.3035 | 0.3035 |
Echinococcus granulosus | semaphorin 5B | 0.0024 | 0.1462 | 0.1462 |
Schistosoma mansoni | semaphorin 5-related | 0.0024 | 0.1462 | 0.1837 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0024 | 0.1462 | 0.0354 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.1721 | 0.1721 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0032 | 0.3035 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0032 | 0.3035 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.3035 | 0.3035 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0032 | 0.3035 | 0.2422 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.1462 | 0.1837 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.3035 | 0.2132 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.1462 | 0.1837 |
Mycobacterium ulcerans | pyruvate kinase | 0.0032 | 0.3035 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0032 | 0.3035 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Echinococcus granulosus | plexin a4 | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | plexin A | 0.0068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.7957 | 0.7692 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Schistosoma mansoni | pyruvate kinase | 0.0032 | 0.3035 | 0.3814 |
Schistosoma mansoni | plexin | 0.0034 | 0.3295 | 0.4141 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1462 | 0.0354 |
Loa Loa (eye worm) | pyruvate kinase | 0.0032 | 0.3035 | 0.2132 |
Echinococcus multilocularis | semaphorin 5B | 0.0024 | 0.1462 | 0.1462 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0032 | 0.3035 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.3295 | 0.4141 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0032 | 0.3035 | 1 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0032 | 0.3035 | 0.1843 |
Plasmodium vivax | pyruvate kinase, putative | 0.0032 | 0.3035 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.