Detailed information for compound 176481

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 236.267 | Formula: C12H16N2O3
  • H donors: 0 H acceptors: 2 LogP: 1.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1c(=O)on(c1C)C(=O)N1CC=CC1)C
  • InChi: 1S/C12H16N2O3/c1-8(2)10-9(3)14(17-11(10)15)12(16)13-6-4-5-7-13/h4-5,8H,6-7H2,1-3H3
  • InChiKey: MACAGOCXWBPXTQ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Hormone-sensitive lipase Starlite/ChEMBL References
Homo sapiens lipase, hormone-sensitive Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Echinococcus granulosus hormone sensitive lipase Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma mansoni hormone-sensitive lipase (S09 family) Get druggable targets OG5_132840 All targets in OG5_132840
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132840 All targets in OG5_132840
Echinococcus multilocularis hormone sensitive lipase Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum Hormone-sensitive lipase, putative Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum Hormone-sensitive lipase, putative Get druggable targets OG5_132840 All targets in OG5_132840
Schistosoma japonicum ko:K07188 hormone-sensitive lipase [EC3.1.1.79], putative Get druggable targets OG5_132840 All targets in OG5_132840

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.0412 0.0412
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) TYRA-2 protein 0.006 0.0412 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Echinococcus multilocularis g-protein coupled receptor 0.006 0.0412 0.0414
Schistosoma mansoni myosin xvIII 0.006 0.0412 0.0414
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0622 1
Schistosoma mansoni hypothetical protein 0.006 0.0412 0.0414
Brugia malayi G-protein coupled receptor 0.006 0.0412 0.0412
Schistosoma mansoni adenoreceptor 0.006 0.0412 0.0414
Brugia malayi MAP kinase sur-1 0.0059 0.0382 0.0382
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0412 0.0414
Brugia malayi Serotonin receptor 0.006 0.0412 0.0412
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.0412 0.0412
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0382 0.5
Schistosoma mansoni neuropeptide receptor 0.006 0.0412 0.0414
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0412 0.0414
Echinococcus multilocularis orexin receptor type 2 0.006 0.0412 0.0414
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.0412 0.0414
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0382 0.0385
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0412 0.0412
Schistosoma mansoni neuropeptide receptor 0.006 0.0412 0.0414
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.054 0.0543
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.054 0.054
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.0412 0.0412
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.0412 0.0414
Echinococcus granulosus serotonin receptor 0.006 0.0412 0.0414
Onchocerca volvulus 0.006 0.0412 0.0412
Schistosoma mansoni biogenic amine receptor 0.006 0.0412 0.0414
Schistosoma mansoni thyroid hormone receptor 0.0185 0.3089 0.3108
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0412 0.0414
Onchocerca volvulus 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni opsin-like receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0382 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0412 0.0414
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.0412 0.0412
Echinococcus granulosus G protein coupled receptor 139 0.006 0.0412 0.0414
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0412 0.0414
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0382 0.0385
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.0412 0.0414
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.0412 0.0412
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.054 0.6566
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0412 0.0414
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0622 0.0626
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0412 0.0414
Schistosoma mansoni opsin-like receptor 0.006 0.0412 0.0414
Echinococcus multilocularis hormone sensitive lipase 0.0506 0.9939 1
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0382 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.0412 0.0414
Echinococcus multilocularis neuropeptide receptor 0.006 0.0412 0.0414
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0412 0.0414
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.0412 0.0414
Echinococcus granulosus g protein coupled receptor 0.006 0.0412 0.0414
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0506 0.9939 1
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0412 0.0414
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0412 0.0414
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.0412 0.0414
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.0412 0.0412
Onchocerca volvulus 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni histamine h1 receptor 0.006 0.0412 0.0414
Echinococcus granulosus neuropeptide s receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0382 0.0385
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0622 0.0626
Brugia malayi Dopamine receptor protein 2 0.006 0.0412 0.0412
Onchocerca volvulus 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Onchocerca volvulus 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0506 0.9939 0.9939
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0412 0.0414
Schistosoma mansoni hypothetical protein 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Onchocerca volvulus 0.006 0.0412 0.0412
Brugia malayi follicle stimulating hormone receptor 0.0324 0.6056 0.6056
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni hypothetical protein 0.0145 0.2221 0.2235
Echinococcus multilocularis neuropeptide receptor 0.006 0.0412 0.0414
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.0412 0.0414
Echinococcus granulosus g-protein coupled receptor 0.006 0.0412 0.0414
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0622 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0622 1
Onchocerca volvulus 0.006 0.0412 0.0412
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0412 0.0414
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0622 0.0626
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus neuropeptide receptor A26 0.006 0.0412 0.0414
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0382 0.0385
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.0412 0.0414
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0382 0.0382
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0412 0.0414
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0412 0.0414
Brugia malayi Dopamine receptor protein 1 0.006 0.0412 0.0412
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.0412 0.0414
Onchocerca volvulus 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Onchocerca volvulus 0.006 0.0412 0.0412
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis fmrfamide receptor 0.006 0.0412 0.0414
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0412 0.0414
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.0412 0.0414
Onchocerca volvulus 0.006 0.0412 0.0412
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0506 0.9939 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Trypanosoma brucei protein kinase, putative 0.0059 0.0382 0.5
Echinococcus multilocularis sex peptide receptor 0.006 0.0412 0.0414
Schistosoma mansoni hypothetical protein 0.006 0.0412 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.0412 0.0414
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0412 0.0414
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.0412 0.0414
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0324 0.6056 0.6056
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.0509 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.0412 0.0414
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0412 0.0414
Brugia malayi sulfakinin receptor protein 0.006 0.0412 0.0412
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.054 0.0543
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.0412 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0622 0.0626
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.0412 0.0414
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0622 1
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.0412 0.0412
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.0412 0.0412
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis somatostatin receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0412 0.0414
Brugia malayi G protein-coupled receptor 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis g protein coupled receptor 0.006 0.0412 0.0414
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0412 0.0414
Brugia malayi Dopamine receptor 0.006 0.0412 0.0412
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0412 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0445 0.0445
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.0509 1 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus hormone sensitive lipase 0.0506 0.9939 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0412 0.0414
Brugia malayi AKH receptor 0.006 0.0412 0.0412
Schistosoma mansoni hypothetical protein 0.006 0.0412 0.0414
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0412 0.0414
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0382 0.5
Echinococcus granulosus hypothetical protein 0.006 0.0412 0.0414
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.0412 0.0412
Schistosoma mansoni biogenic amine receptor 0.006 0.0412 0.0414
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.0412 0.0414
Echinococcus multilocularis g protein coupled receptor 0.006 0.0412 0.0414
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0412 0.0414
Echinococcus granulosus sex peptide receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.054 0.0543
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0412 0.0414
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.0412 0.0414
Schistosoma mansoni amine GPCR 0.006 0.0412 0.0414
Loa Loa (eye worm) runx1 0.0064 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus allatostatin A receptor 0.006 0.0412 0.0414
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus fmrfamide receptor 0.006 0.0412 0.0414
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0412 0.0414
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.2221 0.2235
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0412 0.0414
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0382 0.5
Brugia malayi neuropeptide F receptor 0.006 0.0412 0.0412
Schistosoma mansoni thyroid hormone receptor 0.0185 0.3089 0.3108
Brugia malayi Melatonin receptor type 1A 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0412 0.0414
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0412 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Echinococcus multilocularis neuropeptide s receptor 0.006 0.0412 0.0414
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.0412 0.0414
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.0412 0.0414
Schistosoma mansoni neuropeptide receptor 0.006 0.0412 0.0414
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0412 0.0414
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni amine GPCR 0.006 0.0412 0.0414
Schistosoma mansoni lozenge 0.0064 0.0495 0.0498
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.0412 0.0412
Onchocerca volvulus 0.006 0.0412 0.0412
Echinococcus multilocularis serotonin receptor 0.006 0.0412 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Onchocerca volvulus 0.006 0.0412 0.0412
Echinococcus granulosus orexin receptor type 2 0.006 0.0412 0.0414
Brugia malayi Serotonin receptor 0.006 0.0412 0.0412
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0412 0.0414
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0382 0.5
Echinococcus granulosus neuropeptide receptor 0.006 0.0412 0.0414
Echinococcus multilocularis serotonin receptor 0.006 0.0412 0.0414
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.0412 0.0414
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0412 0.0414
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0412 0.0414
Schistosoma mansoni amine GPCR 0.006 0.0412 0.0414
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0382 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.0412 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Schistosoma mansoni amine GPCR 0.006 0.0412 0.0414
Brugia malayi RE15519p 0.006 0.0412 0.0412
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.2221 0.2235
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0412 0.0414
Brugia malayi ORL1-like opioid receptor 0.006 0.0412 0.0412
Echinococcus granulosus neuropeptide receptor 0.006 0.0412 0.0414
Echinococcus multilocularis Protein lozenge 0.0064 0.0495 0.0498
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0412 0.0414
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.0412 0.0414
Echinococcus multilocularis thyroid hormone receptor alpha 0.0185 0.3089 0.3108
Schistosoma mansoni opsin-like receptor 0.006 0.0412 0.0414
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0622 1
Echinococcus multilocularis neuropeptide receptor A26 0.006 0.0412 0.0414
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0412 0.0414
Schistosoma mansoni biogenic amine receptor 0.006 0.0412 0.0414
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.0412 0.0414
Brugia malayi G-protein coupled receptor 0.006 0.0412 0.0412
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0382 0.5
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus somatostatin receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0412 0.0412
Onchocerca volvulus 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Brugia malayi neuropeptide F receptor 0.006 0.0412 0.0412
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni neuropeptide receptor 0.006 0.0412 0.0414
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni amine GPCR 0.006 0.0412 0.0414
Onchocerca volvulus 0.006 0.0412 0.0412
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0412 0.0414
Onchocerca volvulus 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus g protein coupled receptor 0.006 0.0412 0.0414
Brugia malayi larval opioid receptor 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.0412 0.0412
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0382 0.5
Onchocerca volvulus 0.006 0.0412 0.0412
Echinococcus multilocularis allatostatin A receptor 0.006 0.0412 0.0414
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.0412 0.0414
Echinococcus multilocularis fmrfamide receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.0412 0.0414
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0382 0.5
Onchocerca volvulus 0.006 0.0412 0.0412
Brugia malayi hypothetical protein 0.006 0.0412 0.0412
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0506 0.9939 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0412 0.0414
Brugia malayi putative neuropeptide receptor 0.006 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0382 0.0385
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0412 0.0414
Echinococcus multilocularis g protein coupled receptor 0.006 0.0412 0.0414
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0622 1
Onchocerca volvulus 0.0509 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0412 0.0412
Echinococcus granulosus g protein coupled receptor 0.006 0.0412 0.0414
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.0412 0.0414
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0412 0.0414
Brugia malayi GnHR receptor homolog 0.006 0.0412 0.0412

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 72 nM Inhibition of human recombinant hormone sensitive lipase (HSL) ChEMBL. 15149665
IC50 (binding) = 72 nM Inhibition of human recombinant hormone sensitive lipase (HSL) ChEMBL. 15149665
IC50 (binding) = 72 nM Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay ChEMBL. 18808096
IC50 (functional) = 120 nM Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells ChEMBL. 15149665
IC50 (functional) = 120 nM Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells ChEMBL. 15149665

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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