Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor NHR-88 | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0044 | 0.007 | 0.007 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.3838 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0036 | 0.005 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0084 | 0.0084 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0044 | 0.007 | 0.007 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0084 | 0.0084 |
Schistosoma mansoni | coup transcription factor | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | zinc finger protein | 0.0044 | 0.007 | 0.007 |
Leishmania major | pyruvate kinase | 0.0036 | 0.005 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.3838 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0044 | 0.007 | 0.007 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | nuclear hormone receptor | 0.0044 | 0.007 | 0.007 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0019 | 0.0004 | 0.0753 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0036 | 0.005 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0049 | 0.0084 | 0.0084 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0084 | 0.0084 |
Schistosoma mansoni | pyruvate kinase | 0.0019 | 0.0004 | 0.0004 |
Echinococcus granulosus | FTZ F1 alpha | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0004 | 0.0004 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | nuclear hormone receptor | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0084 | 0.0084 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0044 | 0.007 | 0.007 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | DR-78 | 0.0044 | 0.007 | 0.007 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0019 | 0.0004 | 0.0753 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0049 | 0.0084 | 0.0084 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0025 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0093 | 0.0199 | 0.0199 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0044 | 0.007 | 0.007 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0004 | 0.0004 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0044 | 0.007 | 0.1378 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0044 | 0.007 | 0.007 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0036 | 0.005 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0036 | 0.005 | 0.005 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0093 | 0.0199 | 0.0199 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.005 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | nuclear receptor RXR | 0.0049 | 0.0084 | 0.0084 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Leishmania major | pyruvate kinase | 0.0036 | 0.005 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | steroid hormone receptor | 0.0093 | 0.0199 | 0.0199 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0044 | 0.007 | 0.1378 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0044 | 0.007 | 0.007 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0096 | 0.0096 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0093 | 0.0199 | 0.0199 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.005 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0052 | 0.0052 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0021 | 0.0021 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0004 | 0.0004 |
Plasmodium falciparum | pyruvate kinase | 0.0036 | 0.005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | Hyaluronidase | 0.3838 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0044 | 0.007 | 0.007 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0019 | 0.0004 | 0.0753 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | tailless protein | 0.0044 | 0.007 | 0.007 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0093 | 0.0199 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0044 | 0.007 | 0.007 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0049 | 0.0084 | 0.0084 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0093 | 0.0199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0096 | 0.0096 |
Schistosoma mansoni | thyroid hormone receptor | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | thyroid hormone receptor | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0049 | 0.0084 | 0.0084 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0036 | 0.005 | 1 |
Onchocerca volvulus | 0.0044 | 0.007 | 0.1378 | |
Chlamydia trachomatis | pyruvate kinase | 0.0036 | 0.005 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | pyruvate kinase | 0.0029 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0199 | 0.0199 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0052 | 0.0052 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0093 | 0.0199 | 0.0199 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0093 | 0.0199 | 0.0199 |
Giardia lamblia | Pyruvate kinase | 0.0036 | 0.005 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0036 | 0.005 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0044 | 0.007 | 0.007 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0036 | 0.005 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0093 | 0.0199 | 0.0199 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0084 | 0.0084 |
Schistosoma mansoni | nuclear hormone receptor | 0.0044 | 0.007 | 0.007 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0044 | 0.007 | 0.007 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0093 | 0.0199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0084 | 0.0084 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0036 | 0.005 | 0.005 |
Schistosoma mansoni | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0044 | 0.007 | 0.007 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0093 | 0.0199 | 0.0199 |
Plasmodium vivax | pyruvate kinase, putative | 0.0036 | 0.005 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | nuclear hormone receptor | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | nuclear receptor NHR-67 | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0044 | 0.007 | 0.007 |
Onchocerca volvulus | 0.0044 | 0.007 | 0.1378 | |
Schistosoma mansoni | nuclear receptor | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Brugia malayi | nuclear receptor NHR-88 | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0044 | 0.007 | 0.007 |
Schistosoma mansoni | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0044 | 0.007 | 0.007 |
Brugia malayi | conserved hypotetical protein | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.3838 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Echinococcus granulosus | pyruvate kinase | 0.0036 | 0.005 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0084 | 0.0084 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0025 | 0.0021 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0093 | 0.0199 | 0.0199 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0036 | 0.005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.1631 | 0.4222 | 0.4222 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0093 | 0.0199 | 0.0199 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0093 | 0.0199 | 0.0199 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.3838 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0049 | 0.0084 | 0.0084 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0004 | 0.0004 |
Schistosoma mansoni | nuclear receptor | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.005 | 0.005 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0049 | 0.0084 | 0.0084 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0093 | 0.0199 | 0.0199 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0049 | 0.0084 | 0.0084 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0096 | 0.0096 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0093 | 0.0199 | 0.0199 |
Echinococcus granulosus | pyruvate kinase | 0.0019 | 0.0004 | 0.0004 |
Brugia malayi | ecdysteroid receptor | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0093 | 0.0199 | 0.0199 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0093 | 0.0199 | 0.0199 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0093 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Brugia malayi | nuclear receptor RXR | 0.0044 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Onchocerca volvulus | 0.0093 | 0.0199 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.007 | 0.007 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0044 | 0.007 | 0.007 |
Echinococcus multilocularis | pyruvate kinase | 0.0019 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0044 | 0.007 | 0.007 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0093 | 0.0199 | 0.0199 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 46.5 uM | Cytotoxicity against mouse L1210 cells after 24 hrs by MTT assay | ChEMBL. | 23524161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.