Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.00000024917 | 0.00000024917 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0349 | 0.3246 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0982 | 1 | 1 |
Schistosoma mansoni | fusion | 0.0349 | 0.3246 | 0.3246 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0982 | 1 | 0.5 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0349 | 0.3246 | 0.3246 |
Onchocerca volvulus | 0.0349 | 0.3246 | 0.3246 | |
Onchocerca volvulus | 0.0349 | 0.3246 | 0.3246 | |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Onchocerca volvulus | 0.0982 | 1 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0982 | 1 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0349 | 0.3246 | 0.3246 |
Schistosoma mansoni | transient receptor potential channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0349 | 0.3246 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0349 | 0.3246 | 0.3246 |
Schistosoma mansoni | brg-1 associated factor | 0.0982 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0349 | 0.3246 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0349 | 0.3246 | 0.3246 |
Schistosoma mansoni | hypothetical protein | 0.0982 | 1 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0349 | 0.3246 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Toxoplasma gondii | ran binding protein | 0.0349 | 0.3246 | 0.3246 |
Chlamydia trachomatis | SWIB complex protein | 0.0982 | 1 | 0.5 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0349 | 0.3246 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0349 | 0.3246 | 0.3246 |
Loa Loa (eye worm) | brahma associated protein | 0.0982 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.00000024917 | 0.00000024917 |
Schistosoma mansoni | hypothetical protein | 0.0982 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0982 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0982 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0349 | 0.3246 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0982 | 1 | 1 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0349 | 0.3246 | 0.3246 |
Brugia malayi | olfactory channel protein osm-9 | 0.0045 | 0.00000024917 | 0.00000024917 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0982 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0982 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0982 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0349 | 0.3246 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0982 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0349 | 0.3246 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Schistosoma mansoni | RNA binding protein | 0.0349 | 0.3246 | 0.3246 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.00000024917 | 0.00000024917 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0349 | 0.3246 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0982 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0982 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0982 | 1 | 1 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0349 | 0.3246 | 0.3246 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0982 | 1 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0982 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0982 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0349 | 0.3246 | 0.3246 |
Onchocerca volvulus | 0.0349 | 0.3246 | 0.3246 | |
Onchocerca volvulus | 0.0349 | 0.3246 | 0.3246 | |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0982 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0349 | 0.3246 | 0.3246 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0982 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.31 uM | Apomorphine-induced inhibition of potassium evoked release of [3H]- acetylcholine from striatal slices of rat | ChEMBL. | 8230103 |
KB (ADMET) | = 5.1 uM | Calculated antagonist equilibrium dissociation constant of the compound | ChEMBL. | 8230103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.