Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0096 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0506 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0096 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0096 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0096 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0096 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0096 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0096 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0096 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0096 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0096 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0096 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0096 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0096 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0096 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1 | 0.0096 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0096 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0096 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0096 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0096 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0096 | 0 | 0.5 |
Onchocerca volvulus | 0.0096 | 0 | 0.5 | |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0096 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0096 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 111 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | = 111 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | = 111 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
IC50 (functional) | = 1000 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
IC50 (functional) | = 1000 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.