TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 386.852 | Formula: C19H15ClN2O3S
H donors: 1 H acceptors: 3 LogP: 4.74 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCN1/C(=N/c2cccc(c2)C(=O)O)/S/C(=C\c2ccccc2Cl)/C1=O
InChi: 1S/C19H15ClN2O3S/c1-2-22-17(23)16(11-12-6-3-4-9-15(12)20)26-19(22)21-14-8-5-7-13(10-14)18(24)25/h3-11H,2H2,1H3,(H,24,25)/b16-11-,21-19-
InChiKey: KWBWZCYEONYEIP-LCUCDLPVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0057	0.0515	0.0448
Brugia malayi	Histone deacetylase family protein	0.0369	0.6082	0.5987
Echinococcus multilocularis	sex peptide receptor	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0235	0.0166
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0072	0.0776	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0161	0.2367	0.2313
Trypanosoma cruzi	histone deacetylase, putative	0.0161	0.2367	0.2183
Schistosoma mansoni	neuropeptide f receptor 76f	0.0074	0.0815	0.0595
Giardia lamblia	Cathepsin L precursor	0.0057	0.0515	0.0618
Plasmodium vivax	vivapain-3	0.013	0.1822	0.2347
Brugia malayi	Serotonin receptor	0.0074	0.0815	0.0595
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0057	0.0515	0.0618
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0074	0.0815	0.0751
Giardia lamblia	Cathepsin B precursor	0.0057	0.0515	0.0618
Trypanosoma cruzi	histone deacetylase 1, putative	0.0295	0.4767	0.4641
Trypanosoma cruzi	cysteine peptidase, putative	0.0237	0.3738	0.3588
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0799	0.0734
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0799	0.0578
Onchocerca volvulus		0.0074	0.0815	0.1657
Loa Loa (eye worm)	fibroinase	0.0237	0.3738	0.3694
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0815	0.0595
Echinococcus granulosus	histone deacetylase	0.0369	0.6082	0.5987
Giardia lamblia	Cathepsin B precursor	0.0057	0.0515	0.0618
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0515	0.108
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Trypanosoma cruzi	cruzipain precursor, putative	0.0237	0.3738	0.3588
Echinococcus multilocularis	cysteine protease	0.0237	0.3738	0.3694
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.013	0.1822	0.1625
Echinococcus multilocularis	cathepsin L cysteine protease	0.0237	0.3738	0.3694
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0607	0.0541
Brugia malayi	cathepsin L-like precursor	0.0164	0.2432	0.225
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Echinococcus granulosus	somatostatin receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Giardia lamblia	Cathepsin L precursor	0.0057	0.0515	0.0618
Entamoeba histolytica	hypothetical protein	0.0057	0.0515	0.0618
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Loa Loa (eye worm)	G-protein coupled receptor	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0235	0.0166
Brugia malayi	Serotonin receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0057	0.0515	0.108
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.0815	0.0595
Schistosoma mansoni	hypothetical protein	0.0074	0.0815	0.0595
Chlamydia trachomatis	peptide deformylase	0.0227	0.3558	0.5
Echinococcus multilocularis	cyclin B	0.0042	0.0235	0.0166
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0815	0.0595
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0515	0.108
Entamoeba histolytica	cysteine proteinase 2	0.013	0.1822	0.3502
Onchocerca volvulus		0.0074	0.0815	0.1657
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.0515	0.0287
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0515	0.0618
Echinococcus granulosus	histone deacetylase 8	0.0161	0.2367	0.2183
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0057	0.0515	0.0287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0515	0.108
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Leishmania major	histone deacetylase, putative	0.0295	0.4767	0.7752
Echinococcus granulosus	cathepsin L	0.013	0.1822	0.1625
Echinococcus multilocularis	neuropeptide s receptor	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Leishmania major	histone deacetylase, putative	0.0295	0.4767	0.7752
Loa Loa (eye worm)	melatonin receptor type 1A	0.0074	0.0815	0.0751
Brugia malayi	calpain family protein 1	0.0044	0.0277	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Entamoeba histolytica	cysteine proteinase, putative	0.013	0.1822	0.3502
Plasmodium vivax	vivapain-2	0.0237	0.3738	0.579
Brugia malayi	neuropeptide F receptor	0.0074	0.0815	0.0595
Trypanosoma brucei	histone deacetylase 4	0.0369	0.6082	1
Schistosoma mansoni	cathepsin C	0.0057	0.0515	0.0287
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0074	0.0815	0.0751
Echinococcus granulosus	7TM GPCR rhodopsin	0.0074	0.0815	0.0595
Giardia lamblia	Encystation-specific protease	0.0057	0.0515	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0074	0.0815	0.0751
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0515	0.108
Toxoplasma gondii	histone deacetylase HDAC4	0.0332	0.5425	0.8821
Brugia malayi	ORL1-like opioid receptor	0.0074	0.0815	0.0595
Echinococcus multilocularis	fmrfamide receptor	0.0074	0.0815	0.0751
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0237	0.3738	0.3694
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0074	0.0815	0.0595
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0588	1	1
Echinococcus granulosus	histone deacetylase 6	0.0369	0.6082	0.5987
Trichomonas vaginalis	histone deacetylase, putative	0.0295	0.4767	1
Onchocerca volvulus		0.0074	0.0815	0.1657
Leishmania major	cysteine peptidase A (CPA)	0.0237	0.3738	0.5992
Leishmania major	histone deacetylase, putative	0.0369	0.6082	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0074	0.0815	0.0751
Giardia lamblia	Cathepsin L precursor	0.0057	0.0515	0.0618
Brugia malayi	cathepsin L-like cysteine proteinase	0.0057	0.0515	0.0287
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.013	0.1822	0.3822
Schistosoma mansoni	amine GPCR	0.0074	0.0815	0.0595
Schistosoma mansoni	opsin-like receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Schistosoma mansoni	voltage-gated potassium channel	0.0078	0.0894	0.0675
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0515	0.0287
Giardia lamblia	Cathepsin B precursor	0.0057	0.0515	0.0618
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.0815	0.0595
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0087	0.1044	0.0828
Plasmodium vivax	histone deacetylase, putative	0.0332	0.5425	0.8821
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0074	0.0815	0.0751
Echinococcus granulosus	cathepsin b	0.0588	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0074	0.0815	0.0595
Echinococcus granulosus	cathepsin L	0.0057	0.0515	0.0287
Schistosoma mansoni	histone deacetylase 1 2 3	0.0161	0.2367	0.2183
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0074	0.0815	0.0595
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0046	0.0312	0.0244
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.0277	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0309	0.5009	0.4974
Schistosoma mansoni	amine GPCR	0.0074	0.0815	0.0595
Entamoeba histolytica	cysteine proteinase, putative	0.0237	0.3738	0.773
Schistosoma mansoni	cathepsin s	0.0073	0.0799	0.0578
Trypanosoma cruzi	histone deacetylase, putative	0.0369	0.6082	0.5987
Echinococcus granulosus	nuclear receptor co repressor related ncor	0.0271	0.4338	0.4202
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0515	0.108
Schistosoma mansoni	amine GPCR	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0515	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Brugia malayi	cathepsin L precursor	0.0057	0.0515	0.0287
Schistosoma mansoni	biogenic amine receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0815	0.0751
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Loa Loa (eye worm)	histone deacetylase	0.0369	0.6082	0.6054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0164	0.2432	0.225
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0277	0.0043
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0235	0.0493
Onchocerca volvulus	Cathepsin L homolog	0.0057	0.0515	0.08
Leishmania major	cathepsin L-like protease	0.0237	0.3738	0.5992
Onchocerca volvulus		0.0237	0.3738	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Loa Loa (eye worm)	cathepsin B	0.0221	0.3449	0.3402
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Echinococcus multilocularis	histone deacetylase 3	0.0295	0.4767	0.473
Onchocerca volvulus		0.0074	0.0815	0.1657
Giardia lamblia	Cathepsin B precursor	0.0057	0.0515	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Onchocerca volvulus		0.0074	0.0815	0.1657
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.0815	0.0751
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0074	0.0815	0.0751
Onchocerca volvulus		0.0209	0.3223	0.853
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.0515	0.108
Schistosoma mansoni	histone deacetylase	0.0295	0.4767	0.4641
Onchocerca volvulus	Cathepsin L homolog	0.0237	0.3738	1
Entamoeba histolytica	cysteine proteinase, putative	0.013	0.1822	0.3502
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Echinococcus granulosus	histone deacetylase 3	0.0295	0.4767	0.4641
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0074	0.0815	0.0595
Trypanosoma cruzi	cysteine protease, putative	0.013	0.1822	0.1625
Mycobacterium ulcerans	peptide deformylase	0.0227	0.3558	0.5
Echinococcus granulosus	g protein coupled receptor	0.0074	0.0815	0.0595
Onchocerca volvulus		0.0074	0.0815	0.1657
Brugia malayi	Cathepsin L-like precursor	0.0073	0.0799	0.0578
Brugia malayi	G-protein coupled receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Onchocerca volvulus		0.0237	0.3738	1
Echinococcus granulosus	g protein coupled receptor	0.0074	0.0815	0.0595
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.0815	0.0595
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0074	0.0815	0.0595
Giardia lamblia	Cathepsin L precursor	0.0057	0.0515	0.0618
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0799	0.0734
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0074	0.0815	0.0595
Echinococcus granulosus	neuropeptide FF receptor 2	0.0074	0.0815	0.0595
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.0815	0.0595
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Brugia malayi	Melatonin receptor type 1A	0.0074	0.0815	0.0595
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Giardia lamblia	Cathepsin L-like protease	0.0057	0.0515	0.0618
Trypanosoma cruzi	cysteine peptidase, putative	0.013	0.1822	0.1625
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0074	0.0815	0.0595
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Brugia malayi	AKH receptor	0.0074	0.0815	0.0595
Schistosoma mansoni	cathepsin F (C01 family)	0.0237	0.3738	0.3588
Onchocerca volvulus		0.0074	0.0815	0.1657
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0073	0.0799	0.0578
Plasmodium falciparum	peptide deformylase	0.0227	0.3558	0.5466
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0235	0.0493
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0237	0.3738	0.3694
Plasmodium vivax	unspecified product	0.013	0.1822	0.2347
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Giardia lamblia	Cathepsin B precursor	0.0221	0.3449	0.7091
Loa Loa (eye worm)	hypothetical protein	0.0208	0.3207	0.316
Trypanosoma brucei	histone deacetylase, putative	0.0369	0.6082	1
Brugia malayi	Cathepsin L-like precursor	0.0237	0.3738	0.3588
Echinococcus granulosus	cathepsin l1	0.0164	0.2432	0.225
Echinococcus granulosus	calpain A	0.0046	0.0312	0.0079
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0815	0.0751
Echinococcus multilocularis	neuropeptide receptor A26	0.0074	0.0815	0.0751
Toxoplasma gondii	histone deacetylase HDAC2	0.0295	0.4767	0.7638
Loa Loa (eye worm)	hypothetical protein	0.0171	0.2551	0.2498
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0057	0.0515	0.0618
Leishmania major	histone deacetylase, putative	0.0369	0.6082	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0164	0.2432	0.2378
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Echinococcus granulosus	cathepsin b	0.0588	1	1
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0515	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0515	0.0287
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0074	0.0815	0.0751
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Schistosoma mansoni	hypothetical protein	0.0074	0.0815	0.0595
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0221	0.3449	0.5497
Echinococcus multilocularis	cathepsin L	0.013	0.1822	0.1764
Trichomonas vaginalis	cyclins, putative	0.0042	0.0235	0.0493
Brugia malayi	G protein-coupled receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0074	0.0815	0.0595
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0074	0.0815	0.0595
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0074	0.0815	0.0751
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0057	0.0515	0.0618
Loa Loa (eye worm)	cysteine protease	0.0237	0.3738	0.3694
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0074	0.0815	0.0751
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0815	0.0751
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0074	0.0815	0.0751
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0815	0.0595
Brugia malayi	Histone deacetylase 1	0.0295	0.4767	0.4641
Echinococcus multilocularis	histone deacetylase 6	0.0369	0.6082	0.6054
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0074	0.0815	0.0595
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0057	0.0515	0.0287
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0074	0.0815	0.0751
Trichomonas vaginalis	histone deacetylase, putative	0.0295	0.4767	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0057	0.0515	0.0287
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0057	0.0515	0.0287
Leishmania major	cathepsin L-like protease	0.0237	0.3738	0.5992
Schistosoma mansoni	neuropeptide receptor	0.0074	0.0815	0.0595
Onchocerca volvulus		0.0074	0.0815	0.1657
Brugia malayi	Dopamine receptor	0.0074	0.0815	0.0595
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0074	0.0815	0.0595
Echinococcus multilocularis	serotonin receptor	0.0074	0.0815	0.0751
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.0515	0.0287
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0515	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0164	0.2432	0.2378
Toxoplasma gondii	histone deacetylase HDAC3	0.0295	0.4767	0.7638
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Onchocerca volvulus		0.0237	0.3738	1
Echinococcus multilocularis	g-protein coupled receptor	0.0074	0.0815	0.0751
Echinococcus multilocularis	allatostatin A receptor	0.0209	0.3223	0.3176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Leishmania major	cathepsin L-like protease	0.0237	0.3738	0.5992
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0515	0.108
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0074	0.0815	0.0595
Echinococcus granulosus	neuropeptides capa receptor	0.0074	0.0815	0.0595
Trypanosoma cruzi	cysteine peptidase, putative	0.0237	0.3738	0.3588
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0072	0.0776	0.0711
Schistosoma mansoni	amine GPCR	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Toxoplasma gondii	histone deacetylase HDAC1	0.0369	0.6082	1
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0515	0.0448
Loa Loa (eye worm)	histone deacetylase 11	0.0332	0.5425	0.5393
Trypanosoma brucei	histone deacetylase 2	0.0161	0.2367	0.3646
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0227	0.3558	0.5
Echinococcus granulosus	serotonin receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0074	0.0815	0.0751
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0815	0.0751
Onchocerca volvulus		0.0074	0.0815	0.1657
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.013	0.1822	0.3822
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0309	0.5009	0.4889
Echinococcus multilocularis	histone deacetylase 1	0.0295	0.4767	0.473
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0588	1	1
Echinococcus granulosus	neuropeptide receptor	0.0074	0.0815	0.0595
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0087	0.1044	0.0828
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0161	0.2367	0.6085
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0046	0.0312	0.0079
Toxoplasma gondii	hypothetical protein	0.0227	0.3558	0.5466
Trypanosoma cruzi	histone deacetylase, putative	0.0369	0.6082	0.5987
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0515	0.108
Schistosoma mansoni	cathepsin S (C01 family)	0.0057	0.0515	0.0287
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0815	0.0751
Brugia malayi	histone deacetylase 11	0.0332	0.5425	0.5315
Echinococcus granulosus	histone deacetylase 7	0.0369	0.6082	0.5987
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0046	0.0312	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Echinococcus multilocularis	orexin receptor type 2	0.0074	0.0815	0.0751
Leishmania major	cathepsin L-like protease	0.0237	0.3738	0.5992
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0188	0.0119
Schistosoma mansoni	growth hormone secretagogue receptor	0.0074	0.0815	0.0595
Echinococcus multilocularis	nuclear receptor co repressor related (ncor)	0.0271	0.4338	0.4298
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Echinococcus multilocularis	dro:myosuppressin receptor	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0237	0.3738	0.3694
Echinococcus granulosus	7tm_1 domain containing protein	0.0074	0.0815	0.0595
Echinococcus multilocularis	cathepsin L	0.0057	0.0515	0.0448
Echinococcus multilocularis	neuropeptide receptor	0.0074	0.0815	0.0751
Echinococcus granulosus	cysteine protease	0.013	0.1822	0.1625
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.0815	0.0751
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0074	0.0815	0.0751
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Trypanosoma cruzi	cysteine proteinase, putative	0.013	0.1822	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Giardia lamblia	Hypothetical protein	0.0057	0.0515	0.0618
Trypanosoma cruzi	cysteine peptidase, putative	0.0237	0.3738	0.3588
Giardia lamblia	Cathepsin B precursor	0.0057	0.0515	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0237	0.3738	0.3694
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0227	0.3558	0.5
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0295	0.4767	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0074	0.0815	0.0595
Entamoeba histolytica	cysteine proteinase, putative	0.0237	0.3738	0.773
Schistosoma mansoni	neuropeptide receptor	0.0074	0.0815	0.0595
Giardia lamblia	Hypothetical protein	0.0057	0.0515	0.0618
Echinococcus multilocularis	somatostatin receptor	0.0074	0.0815	0.0751
Onchocerca volvulus	Cathepsin L homolog	0.0237	0.3738	1
Echinococcus granulosus	histone deacetylase 6	0.0369	0.6082	0.5987
Toxoplasma gondii	cathepsin B	0.0221	0.3449	0.527
Onchocerca volvulus		0.0237	0.3738	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0074	0.0815	0.0595
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Echinococcus granulosus	histone deacetylase 1	0.0295	0.4767	0.4641
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Onchocerca volvulus		0.0074	0.0815	0.1657
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.013	0.1822	0.1625
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0057	0.0515	0.108
Echinococcus granulosus	hypothetical protein	0.0074	0.0815	0.0595
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0046	0.0312	0.0079
Trypanosoma brucei	Peptide deformylase 2	0.0087	0.1044	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0515	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0799	0.0734
Trypanosoma brucei	histone deacetylase 1	0.0295	0.4767	0.7752
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0515	0.108
Entamoeba histolytica	cysteine proteinase, putative	0.013	0.1822	0.3502
Brugia malayi	Cathepsin L-like precursor	0.0164	0.2432	0.225
Echinococcus granulosus	sex peptide receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	neuropeptide F receptor	0.0074	0.0815	0.0751
Giardia lamblia	Cathepsin L-like protease	0.0057	0.0515	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0057	0.0515	0.0448
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.013	0.1822	0.2714
Loa Loa (eye worm)	hypothetical protein	0.0164	0.2432	0.2378
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0057	0.0515	0.0287
Giardia lamblia	Cathepsin B precursor	0.0221	0.3449	0.7091
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0221	0.3449	0.3291
Trypanosoma cruzi	histone deacetylase 1, putative	0.0295	0.4767	0.4641
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.0515	0.0287
Onchocerca volvulus		0.0237	0.3738	1
Treponema pallidum	polypeptide deformylase (def)	0.0227	0.3558	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Schistosoma mansoni	opsin-like receptor	0.0074	0.0815	0.0595
Trypanosoma cruzi	cysteine proteinase, putative	0.013	0.1822	0.1625
Brugia malayi	Papain family cysteine protease containing protein	0.013	0.1822	0.1625
Echinococcus multilocularis	cathepsin b	0.0588	1	1
Trichomonas vaginalis	histone deacetylase, putative	0.0295	0.4767	1
Echinococcus granulosus	neuropeptide receptor A26	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0515	0.0448
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0074	0.0815	0.0751
Echinococcus multilocularis	neuropeptide receptor	0.0074	0.0815	0.0751
Echinococcus granulosus	g protein coupled receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0073	0.0799	0.0734
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0235	0.0493
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0515	0.0618
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0074	0.0815	0.0595
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0237	0.3738	0.579
Schistosoma mansoni	histone deacetylase hda2	0.0161	0.2367	0.2183
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Loa Loa (eye worm)	neuropeptide F receptor	0.0074	0.0815	0.0751
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0072	0.0776	0.0554
Schistosoma mansoni	voltage-gated potassium channel	0.0078	0.0894	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0515	0.0448
Schistosoma mansoni	cathepsin F (C01 family)	0.0164	0.2432	0.225
Schistosoma mansoni	histone deacetylase 4 5	0.0369	0.6082	0.5987
Echinococcus multilocularis	G protein coupled receptor 139	0.0074	0.0815	0.0751
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Onchocerca volvulus		0.0074	0.0815	0.1657
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0074	0.0815	0.0595
Entamoeba histolytica	cysteine proteinase, putative	0.0164	0.2432	0.4847
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0588	1	1
Schistosoma mansoni	myosin xvIII	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0209	0.3223	0.3176
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Schistosoma mansoni	neuropeptide F-like receptor	0.0074	0.0815	0.0595
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0588	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0072	0.0776	0.0554
Leishmania major	polypeptide deformylase-like protein, putative	0.0087	0.1044	0.1383
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0074	0.0815	0.0595
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0057	0.0515	0.0287
Plasmodium falciparum	histone deacetylase 2	0.0369	0.6082	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0815	0.0751
Loa Loa (eye worm)	histone deacetylase 1	0.0295	0.4767	0.473
Brugia malayi	RE15519p	0.0074	0.0815	0.0595
Schistosoma mansoni	histone deacetylase hda2	0.0375	0.619	0.6098
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Trypanosoma brucei	Polypeptide deformylase 1	0.0087	0.1044	0.1383
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Echinococcus granulosus	fmrfamide receptor	0.0074	0.0815	0.0595
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0074	0.0815	0.0595
Echinococcus granulosus	cathepsin L cysteine protease	0.013	0.1822	0.1625
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0057	0.0515	0.0618
Trypanosoma brucei	histone deacetylase 3	0.0369	0.6082	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0074	0.0815	0.0595
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0074	0.0815	0.0751
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0057	0.0515	0.108
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0237	0.3738	0.3588
Echinococcus granulosus	g-protein coupled receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	cyclin A, putative	0.0042	0.0235	0.0493
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0057	0.0515	0.0618
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0164	0.2432	0.5101
Echinococcus granulosus	histone deacetylase 6	0.0375	0.619	0.6098
Echinococcus granulosus	cathepsin l1	0.0237	0.3738	0.3588
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0074	0.0815	0.0595
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	cyclins, putative	0.0042	0.0235	0.0493
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0799	0.0578
Schistosoma mansoni	hypothetical protein	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0515	0.108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Plasmodium falciparum	histone deacetylase 1	0.0295	0.4767	0.7638
Echinococcus granulosus	neuropeptide receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0515	0.0448
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0515	0.0287
Giardia lamblia	Cysteine protease	0.0057	0.0515	0.0618
Brugia malayi	Cathepsin L-like precursor	0.0237	0.3738	0.3588
Giardia lamblia	Histone deacetylase	0.0295	0.4767	1
Brugia malayi	Papain family cysteine protease containing protein	0.0237	0.3738	0.3588
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Echinococcus multilocularis	histone deacetylase 7	0.0369	0.6082	0.6054
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0057	0.0515	0.0448
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.013	0.1822	0.1625
Schistosoma mansoni	neuropeptide receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0277	0.0208
Brugia malayi	Cathepsin L-like precursor	0.0237	0.3738	0.3588
Plasmodium falciparum	histone deacetylase, putative	0.0369	0.6082	1
Toxoplasma gondii	histone deacetylase HDAC5	0.0161	0.2367	0.3326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Loa Loa (eye worm)	hypothetical protein	0.0588	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0057	0.0515	0.0287
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0087	0.1044	0.0828
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0295	0.4767	1
Echinococcus multilocularis	histone deacetylase 8	0.0161	0.2367	0.2313
Echinococcus granulosus	allatostatin A receptor	0.0209	0.3223	0.306
Brugia malayi	fibroinase precursor	0.0057	0.0515	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0588	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0815	0.0595
Onchocerca volvulus		0.0164	0.2432	0.627
Brugia malayi	GnHR receptor homolog	0.0074	0.0815	0.0595
Leishmania major	cathepsin L-like protease	0.0237	0.3738	0.5992
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.0515	0.108
Plasmodium vivax	histone deacetylase 2, putative	0.0369	0.6082	1
Trichomonas vaginalis	histone deacetylase, putative	0.0295	0.4767	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Echinococcus granulosus	orexin receptor type 2	0.0074	0.0815	0.0595
Brugia malayi	Cathepsin L-like precursor	0.0164	0.2432	0.225
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0074	0.0815	0.0595
Onchocerca volvulus		0.0057	0.0515	0.08
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Schistosoma mansoni	biogenic amine receptor	0.0074	0.0815	0.0595
Brugia malayi	Dopamine receptor protein 1	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Echinococcus multilocularis	histone deacetylase 6	0.0369	0.6082	0.6054
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0087	0.1044	0.0828
Echinococcus multilocularis	neuropeptides capa receptor	0.0074	0.0815	0.0751
Loa Loa (eye worm)	ctsf protein	0.0237	0.3738	0.3694
Echinococcus granulosus	biogenic amine 5HT receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0237	0.3738	0.7842
Brugia malayi	larval opioid receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0237	0.3738	0.3694
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0067	0.0692	0.1451
Schistosoma mansoni	cathepsin B (C01 family)	0.0057	0.0515	0.0287
Echinococcus multilocularis	serotonin receptor	0.0074	0.0815	0.0751
Echinococcus granulosus	neuropeptide s receptor	0.0074	0.0815	0.0595
Schistosoma mansoni	neuropeptide receptor	0.0074	0.0815	0.0595
Plasmodium vivax	vivapain-2	0.0237	0.3738	0.579
Echinococcus multilocularis	fmrfamide receptor	0.0074	0.0815	0.0751
Onchocerca volvulus	Cathepsin F homolog	0.0237	0.3738	1
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0227	0.3558	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0815	0.0595
Entamoeba histolytica	histone deacetylase, putative	0.0295	0.4767	1
Schistosoma mansoni	hypothetical protein	0.0074	0.0815	0.0595
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0164	0.2432	0.225
Onchocerca volvulus		0.0074	0.0815	0.1657
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0209	0.3223	0.306
Echinococcus multilocularis	cathepsin L cysteine protease	0.0237	0.3738	0.3694
Plasmodium vivax	unspecified product	0.0073	0.0799	0.051
Loa Loa (eye worm)	G-protein coupled receptor	0.0074	0.0815	0.0751
Brugia malayi	G-protein coupled receptor	0.0074	0.0815	0.0595
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Echinococcus multilocularis	calpain A	0.0046	0.0312	0.0244
Echinococcus multilocularis	cysteine protease	0.0237	0.3738	0.3694
Brugia malayi	follicle stimulating hormone receptor	0.0074	0.0815	0.0595
Brugia malayi	Cathepsin L-like precursor	0.0237	0.3738	0.3588
Giardia lamblia	Cathepsin L precursor	0.0057	0.0515	0.0618
Echinococcus multilocularis	histone deacetylase 6	0.0375	0.619	0.6163
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.0815	0.0751
Echinococcus multilocularis	histone deacetylase	0.0369	0.6082	0.6054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0237	0.3738	0.7842
Loa Loa (eye worm)	histone deacetylase 7A	0.0369	0.6082	0.6054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0815	0.0595
Entamoeba histolytica	cysteine proteinase, putative	0.013	0.1822	0.3502
Schistosoma mansoni	histamine h1 receptor	0.0074	0.0815	0.0595
Brugia malayi	cathepsin F-like cysteine proteinase	0.0057	0.0515	0.0287
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0295	0.4767	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Schistosoma mansoni	histone deacetylase 4 5	0.0369	0.6082	0.5987
Echinococcus granulosus	rhodopsin orphan GPCR	0.0074	0.0815	0.0595
Brugia malayi	putative neuropeptide receptor	0.0074	0.0815	0.0595
Echinococcus multilocularis	g protein coupled receptor	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Leishmania major	cathepsin L-like protease	0.0237	0.3738	0.5992
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0815	0.0751
Brugia malayi	cathepsin F-like cysteine proteinase	0.0073	0.0799	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Onchocerca volvulus		0.0074	0.0815	0.1657
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0074	0.0815	0.0751
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.013	0.1822	0.2714
Brugia malayi	histone deacetylase 3 (HD3)	0.0295	0.4767	0.4641
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0237	0.3738	0.3588
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0515	0.108
Schistosoma mansoni	adenoreceptor	0.0074	0.0815	0.0595
Schistosoma mansoni	biogenic amine receptor	0.0074	0.0815	0.0595
Trichomonas vaginalis	histone deacetylase, putative	0.0295	0.4767	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0221	0.3449	0.3291
Echinococcus granulosus	G protein coupled receptor 139	0.0074	0.0815	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Schistosoma mansoni	histone deacetylase	0.0295	0.4767	0.4641
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0074	0.0815	0.1657
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0221	0.3449	0.7234
Entamoeba histolytica	cysteine proteinase 1, putative	0.013	0.1822	0.3502
Brugia malayi	sulfakinin receptor protein	0.0074	0.0815	0.0595
Brugia malayi	Cathepsin L-like precursor	0.0237	0.3738	0.3588
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Brugia malayi	Histone deacetylase family protein	0.0369	0.6082	0.5987
Trypanosoma cruzi	histone deacetylase, putative	0.0369	0.6082	0.5987
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Onchocerca volvulus		0.0237	0.3738	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Loa Loa (eye worm)	hypothetical protein	0.0214	0.3316	0.3269
Giardia lamblia	Cysteine protease	0.0057	0.0515	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Giardia lamblia	Cathepsin B precursor	0.0221	0.3449	0.7091
Onchocerca volvulus		0.0074	0.0815	0.1657
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0237	0.3738	0.579
Trichomonas vaginalis	cyclin B, putative	0.0042	0.0235	0.0493
Echinococcus granulosus	tm gpcr rhodopsin	0.0074	0.0815	0.0595
Brugia malayi	Dopamine receptor protein 2	0.0074	0.0815	0.0595
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0515	0.0618
Giardia lamblia	Cathepsin L precursor	0.0057	0.0515	0.0618
Trichomonas vaginalis	cyclins, putative	0.0042	0.0235	0.0493
Plasmodium vivax	peptide deformylase, putative	0.0227	0.3558	0.5466
Plasmodium falciparum	cysteine proteinase falcipain 1	0.013	0.1822	0.2347
Echinococcus granulosus	neuropeptide Y receptor	0.0074	0.0815	0.0595
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.0515	0.0287
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0074	0.0815	0.0595
Schistosoma mansoni	cathepsin F (C01 family)	0.0237	0.3738	0.3588
Echinococcus granulosus	dro:myosuppressin receptor	0.0074	0.0815	0.0595
Brugia malayi	hypothetical protein	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0057	0.0515	0.108
Echinococcus granulosus	biogenic amine 5HT receptor	0.0074	0.0815	0.0595
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.0515	0.108
Trichomonas vaginalis	histone deacetylase, putative	0.0295	0.4767	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0074	0.0815	0.0595
Schistosoma mansoni	opsin-like receptor	0.0074	0.0815	0.0595
Echinococcus multilocularis	neuropeptide Y receptor	0.0074	0.0815	0.0751
Trypanosoma cruzi	histone deacetylase, putative	0.0161	0.2367	0.2183
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0067	0.0692	0.1451
Onchocerca volvulus		0.0074	0.0815	0.1657
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Leishmania major	cathepsin L-like protease	0.0237	0.3738	0.5992
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Brugia malayi	Papain family cysteine protease containing protein	0.013	0.1822	0.1625
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Echinococcus granulosus	neuropeptides capa receptor	0.0074	0.0815	0.0595
Echinococcus multilocularis	cathepsin b	0.0588	1	1
Schistosoma mansoni	amine GPCR	0.0074	0.0815	0.0595
Loa Loa (eye worm)	TYRA-2 protein	0.0074	0.0815	0.0751
Trypanosoma cruzi	cysteine peptidase, putative	0.0237	0.3738	0.3588
Plasmodium vivax	histone deacetylase, putative	0.0369	0.6082	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Leishmania major	cathepsin L-like protease	0.0237	0.3738	0.5992
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Plasmodium vivax	histone deacetylase 1, putative	0.0295	0.4767	0.7638
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0237	0.3738	0.7842
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0515	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Trichomonas vaginalis	cyclins, putative	0.0042	0.0235	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0815	0.0751
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0057	0.0515	0.0618
Brugia malayi	calpain family protein 1	0.0044	0.0277	0.0043
Brugia malayi	Cathepsin L-like precursor	0.0237	0.3738	0.3588
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0074	0.0815	0.0751
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0309	0.5009	0.4889
Entamoeba histolytica	cysteine protease, putative	0.0237	0.3738	0.773
Entamoeba histolytica	cysteine protease, putative	0.013	0.1822	0.3502
Brugia malayi	neuropeptide F receptor	0.0074	0.0815	0.0595
Giardia lamblia	Cysteine protease	0.0057	0.0515	0.0618
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0164	0.2432	0.5101
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0074	0.0815	0.1657
Echinococcus multilocularis	neuropeptides capa receptor	0.0074	0.0815	0.0751
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0237	0.3738	0.5992
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4767	0.473
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0237	0.3738	0.579
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0515	0.0287
Onchocerca volvulus		0.0074	0.0815	0.1657
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0057	0.0515	0.108
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.0515	0.0287
Echinococcus granulosus	neuropeptide Y receptor	0.0074	0.0815	0.0595
Loa Loa (eye worm)	histone deacetylase 3	0.0295	0.4767	0.473
Brugia malayi	putative neuropeptide receptor NPR1	0.0074	0.0815	0.0595
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0237	0.3738	0.7842
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.013	0.1822	0.1625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0074	0.0815	0.0595
Giardia lamblia	Cysteine protease	0.0057	0.0515	0.0618
Plasmodium vivax	vivapain-1	0.013	0.1822	0.2347
Brugia malayi	histone deacetylase 1 (HD1)	0.0295	0.4767	0.4641
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0074	0.0815	0.0751
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0515	0.108
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0057	0.0515	0.0287
Onchocerca volvulus		0.0237	0.3738	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0221	0.3449	0.5497
Toxoplasma gondii	cathepsin CPL	0.0237	0.3738	0.579

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 43.3 %	Inhibition of Mycobacterium tuberculosis N-terminal His-6-tagged recombinant CysK1 expressed in Escherichia coli BL21 (DE3) at 500 nM after 20 mins by spectrophotometric analysis	ChEMBL.	23879381

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2418509

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1767788