Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0442 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0442 | 0.5 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0442 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0442 | 0.5 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0442 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | 0 | ChEMBL. | 11720857 | |
EC50 (functional) | nM | In vitro agonistic activity against cAMP accumulation level in CHO cells expressing human beta-AR receptor; In active | ChEMBL. | 11720857 |
EC50 (functional) | 0 nM | In vitro agonistic activity against cAMP accumulation level in CHO cells expressing human beta-AR receptor; In active | ChEMBL. | 11720857 |
EC50 (functional) | = 8 nM | In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta3-AR receptor | ChEMBL. | 11720857 |
EC50 (functional) | = 8 nM | In vitro agonistic activity assessed by measurement of cAMP accumulation level in CHO cells expressing human beta3-AR receptor | ChEMBL. | 11720857 |
EC50 (functional) | = 610 nM | In vitro agonistic activity of the compound assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor | ChEMBL. | 11720857 |
EC50 (functional) | = 610 nM | In vitro agonistic activity of the compound assessed by measurement of cAMP accumulation level in CHO cells expressing human beta1-AR receptor | ChEMBL. | 11720857 |
Intrinsic activity (functional) | % | In vitro intrinsic activity is given as percentage of maximal stimulation relative to isoproterenol; In active | ChEMBL. | 11720857 |
Intrinsic activity (functional) | 0 % | In vitro intrinsic activity is given as percentage of maximal stimulation relative to isoproterenol; In active | ChEMBL. | 11720857 |
Intrinsic activity (functional) | = 53 % | In vitro intrinsic activity is given as percentage of maximal stimulation relative to isoproterenol | ChEMBL. | 11720857 |
Intrinsic activity (functional) | = 53 % | In vitro intrinsic activity is given as percentage of maximal stimulation relative to isoproterenol | ChEMBL. | 11720857 |
Intrinsic activity (functional) | > 100 % | In vitro intrinsic activity is given as percentage of maximal stimulation relative to isoproterenol | ChEMBL. | 11720857 |
Intrinsic activity (functional) | > 100 % | In vitro intrinsic activity is given as percentage of maximal stimulation relative to isoproterenol | ChEMBL. | 11720857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.