Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 0.0149 | 0.057 | 0.0394 | |
Schistosoma mansoni | tyrosine kinase | 0.0129 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0531 | 0.4374 | 0.4374 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1097 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.016 | 0.0683 | 0.0683 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0487 | 0.3929 | 0.3929 |
Schistosoma mansoni | tyrosine kinase | 0.0255 | 0.163 | 0.163 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0129 | 0.0377 | 0.0197 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1097 | 1 | 1 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0129 | 0.0377 | 0.0197 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0531 | 0.4374 | 1 |
Echinococcus multilocularis | insulin receptor | 0.016 | 0.0683 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0183 | 0.0183 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0129 | 0.0377 | 0.0377 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0264 | 0.1722 | 0.1722 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0487 | 0.3929 | 0.3929 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0487 | 0.3929 | 0.3816 |
Brugia malayi | Protein kinase domain containing protein | 0.016 | 0.0683 | 0.0323 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.016 | 0.0683 | 0.0683 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0129 | 0.0377 | 0.0377 |
Echinococcus granulosus | roundabout 2 | 0.011 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | TK protein kinase | 0.0148 | 0.056 | 0.056 |
Echinococcus granulosus | insulin receptor | 0.016 | 0.0683 | 0.0683 |
Schistosoma mansoni | tyrosine kinase | 0.0255 | 0.163 | 0.163 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0264 | 0.1722 | 0.1568 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.016 | 0.0683 | 0.051 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 0.1722 | 0.1722 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0264 | 0.1722 | 0.1722 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.1097 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.016 | 0.0683 | 0.0683 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.016 | 0.0683 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0183 | 0.0183 |
Schistosoma mansoni | tyrosine kinase | 0.0487 | 0.3929 | 0.3929 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0487 | 0.3929 | 0.8834 |
Schistosoma mansoni | tyrosine kinase | 0.0264 | 0.1722 | 0.1722 |
Echinococcus multilocularis | hormone sensitive lipase | 0.1097 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0459 | 0.3651 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0255 | 0.163 | 0.163 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 37.5 mg kg-1 | Anticonvulsant activity against N-sulfamoylhexahydrozepine (10 mice were used per dose, ip) | ChEMBL. | 3965710 |
ED50 (functional) | > 37.5 mg kg-1 | Anticonvulsant activity against N-sulfamoylhexahydrozepine (10 mice were used per dose, ip) | ChEMBL. | 3965710 |
ED50 (functional) | > 50 mg kg-1 | Effective dose against Mice ataxia, ip administration | ChEMBL. | 3965710 |
ED50 (functional) | > 50 mg kg-1 | Effective dose against Mice docility, ip administration | ChEMBL. | 3965710 |
ED50 (functional) | > 50 mg kg-1 | Effective dose against loss of righting reflex in mice (10 mice per dose, ip) | ChEMBL. | 3965710 |
ED50 (functional) | > 50 mg kg-1 | Effective dose against Mice ataxia, ip administration | ChEMBL. | 3965710 |
ED50 (functional) | > 50 mg kg-1 | Effective dose against Mice docility, ip administration | ChEMBL. | 3965710 |
ED50 (functional) | > 50 mg kg-1 | Effective dose against loss of righting reflex in mice (10 mice per dose, ip) | ChEMBL. | 3965710 |
LD50 (ADMET) | > 400 mg kg-1 | Lethal dose was obtained by 2-h post administration (ip), using four male Royal Hart Wistar rats | ChEMBL. | 3965710 |
ND50 (functional) | > 37.5 mg kg-1 | Ability to produce neurological deficit in the rotorod test (10 mice were used per dose, ip) | ChEMBL. | 3965710 |
ND50 (functional) | > 37.5 mg kg-1 | Ability to produce neurological deficit in the rotorod test (10 mice were used per dose, ip) | ChEMBL. | 3965710 |
RD50 (functional) | > 37.5 mg kg-1 | Ability to reinduce anesthesia (70 mg/kg, iv) following recovery of loss of righting reflex obtained with hexobarbital. | ChEMBL. | 3965710 |
RD50 (functional) | > 37.5 mg kg-1 | Ability to reinduce anesthesia (70 mg/kg, iv) following recovery of loss of righting reflex obtained with hexobarbital. | ChEMBL. | 3965710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.