Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipase, hormone-sensitive | Starlite/ChEMBL | References |
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0057 | 0.052 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0053 | 0.0425 | 0.089 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0252 | 0.4633 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0057 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.4782 | 0.4782 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0142 | 0.0142 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0057 | 0.052 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0057 | 0.052 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0259 | 0.4782 | 0.4782 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0142 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0142 | 0.0142 |
Onchocerca volvulus | 0.0053 | 0.0425 | 0.0888 | |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.0142 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0142 | 0.0142 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0142 | 0.5 |
Brugia malayi | hypothetical protein | 0.0259 | 0.4782 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.052 | 0.0812 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0259 | 0.4782 | 0.4782 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0142 | 0.0142 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0057 | 0.052 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0142 | 0.0142 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.052 | 0.0812 |
Brugia malayi | MAP kinase sur-1 | 0.0057 | 0.052 | 0.1087 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0142 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0057 | 0.052 | 0.052 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0057 | 0.052 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0142 | 0.0142 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.0142 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0228 | 0.4126 | 0.8628 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0142 | 0.0142 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0142 | 0.0298 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.0142 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0506 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0057 | 0.052 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.026 | 0.4792 | 1 |
Onchocerca volvulus | 0.0039 | 0.0142 | 0.0297 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.052 | 0.0812 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0142 | 0.0142 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0057 | 0.052 | 0.052 |
Onchocerca volvulus | 0.026 | 0.4792 | 1 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0057 | 0.052 | 0.052 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0142 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0506 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0142 | 0.0142 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0057 | 0.052 | 0.052 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.0142 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0057 | 0.052 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.052 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0142 | 0.2739 |
Onchocerca volvulus | 0.0039 | 0.0142 | 0.0297 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0142 | 0.0142 |
Schistosoma mansoni | survival motor neuron protein | 0.0053 | 0.0425 | 0.0425 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.052 | 0.0812 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0228 | 0.4126 | 0.4126 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.052 | 1 |
Onchocerca volvulus | 0.0039 | 0.0142 | 0.0297 | |
Trypanosoma brucei | protein kinase, putative | 0.0057 | 0.052 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0425 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0142 | 0.0142 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0142 | 0.0298 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0142 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0142 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0057 | 0.052 | 0.052 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | = 5 nM | Inhibition of human recombinant hormone sensitive lipase (HSL) | ChEMBL. | 15149665 |
IC50 (binding) | = 5 nM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
IC50 (functional) | = 90 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
IC50 (functional) | = 90 nM | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | ChEMBL. | 15149665 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.