Detailed information for compound 1777234

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 338.397 | Formula: C21H22O4
  • H donors: 0 H acceptors: 1 LogP: 4.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1Cc1cc2c(C)c(OC)c(c(c2oc1=O)C)C
  • InChi: 1S/C21H22O4/c1-12-13(2)20-17(14(3)19(12)24-5)11-16(21(22)25-20)10-15-8-6-7-9-18(15)23-4/h6-9,11H,10H2,1-5H3
  • InChiKey: OCIKJMOYJJXYOY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 2 (macrophage) Starlite/ChEMBL References
Homo sapiens G protein-coupled receptor 18 Starlite/ChEMBL References
Homo sapiens G protein-coupled receptor 55 Starlite/ChEMBL References
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0034 0.0305 0.0305
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0011 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0124 0.0368
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0027 0.0223 0.0844
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Brugia malayi Dopamine receptor protein 2 0.0017 0.0103 0.015
Entamoeba histolytica fatty acid elongase, putative 0.0087 0.0942 0.739
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0592 0.0592
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0207 0.238 0.238
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0013 0.0054 0.0108
Brugia malayi calcium ATPase 0.0015 0.0074 0.0107
Schistosoma mansoni bromodomain containing protein 0.0009 0.0004 0.0004
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0103
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0103
Plasmodium vivax copper-transporting ATPase, putative 0.0011 0.0025 0.0026
Entamoeba histolytica fatty acid elongase, putative 0.0087 0.0942 0.739
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0579 0.0699
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0124 0.0124
Plasmodium vivax P-type ATPase4, putative 0.0034 0.0305 0.0379
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1266 1
Schistosoma mansoni jun-related protein 0.0067 0.0698 0.0698
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0671 0.7951 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0027 0.0223 0.0223
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0011 0.0025 0.0166
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0027 0.0223 0.0223
Onchocerca volvulus 0.0017 0.0103 0.0271
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0103 0.0271
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0229 0.2639 1
Brugia malayi larval opioid receptor 0.0017 0.0103 0.015
Leishmania major copper-transporting ATPase-like protein, putative 0.0011 0.0025 0.0059
Onchocerca volvulus 0.0017 0.0103 0.0271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0107 0.0103
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.053 0.0798
Brugia malayi Dopamine receptor protein 1 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0207 0.238 0.3605
Brugia malayi DNA-directed RNA polymerase II second largest subunit, putative 0.0013 0.0054 0.0076
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0103
Onchocerca volvulus 0.0017 0.0103 0.0271
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0128 0.0128
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0256 0.2966 0.3621
Schistosoma mansoni zinc finger protein 0.0009 0.0004 0.0004
Schistosoma mansoni type V p-type atpase isoform 0.0011 0.0025 0.0025
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0034 0.0305 0.1123
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0229 0.2639 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0195 0.029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0052 0.0218
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0315 0.1074
Brugia malayi PXA domain containing protein 0.0019 0.0124 0.0183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0175
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0213
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0015 0.0074 0.0697
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0124 0.0183
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0052 0.0518 0.0781
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0256 0.2966 0.3711
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0438 0.153
Echinococcus multilocularis jun protein 0.0082 0.0883 0.0883
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0579 0.0873
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0103 0.0103
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0103
Schistosoma mansoni biogenic amine receptor 0.0017 0.0103 0.0103
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0103 0.015
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0124 0.0124
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0016 0.0092 0.0134
Echinococcus granulosus nervana 2 0.0127 0.1422 0.1422
Schistosoma mansoni transmemberane protein 0.0207 0.238 0.238
Echinococcus multilocularis serotonin receptor 0.0017 0.0103 0.0103
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0124 0.0124
Echinococcus multilocularis nervana 2 0.0207 0.238 0.238
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0991 0.3733
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0195 0.0214
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0052 0.0195
Loa Loa (eye worm) hypothetical protein 0.003 0.0259 0.0388
Brugia malayi DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide 0.0013 0.0054 0.0076
Brugia malayi AKH receptor 0.0017 0.0103 0.015
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0034 0.0305 0.1123
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0315 0.2338
Brugia malayi Cytochrome P450 family protein 0.0024 0.0185 0.0275
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0136 0.0201
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0034 0.0305 0.1123
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0103 0.0103
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni ap endonuclease 0.002 0.0136 0.0136
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0579 0.2167
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0011 0.0025 0.0059
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0027 0.0223 0.2177
Onchocerca volvulus 0.0017 0.0103 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0124 0.0368
Trichomonas vaginalis DNA-directed RNA polymerase III subunit, putative 0.0013 0.0054 0.0108
Onchocerca volvulus 0.0031 0.0263 0.0866
Plasmodium vivax SET domain protein, putative 0.003 0.0259 0.0321
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0671 0.7951 1
Plasmodium falciparum calcium-transporting ATPase 0.0027 0.0223 0.0269
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0107 0.0103
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.8006 0.8006
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0611 0.7224 0.9082
Loa Loa (eye worm) acetyltransferase 0.0296 0.3449 0.5229
Trypanosoma brucei P-type H+-ATPase, putative 0.0022 0.0156 0.0557
Loa Loa (eye worm) hypothetical protein 0.0558 0.6594 1
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0023 0.0173 0.0188
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0034 0.0305 0.1123
Entamoeba histolytica DNA-directed RNA polymerase subunit, putative 0.0013 0.0054 0.0236
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0229 0.2639 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0124 0.0124
Loa Loa (eye worm) phosphofructokinase 0.0114 0.1266 0.1915
Onchocerca volvulus 0.0017 0.0103 0.0271
Schistosoma mansoni histamine h1 receptor 0.0017 0.0103 0.0103
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0076 0.0811 0.817
Trichomonas vaginalis cation-transporting ATPase, putative 0.0022 0.0156 0.0486
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0579 0.0579
Plasmodium vivax DNA-directed RNA polymerase III subunit, putative 0.0013 0.0054 0.0063
Echinococcus granulosus serotonin receptor 0.0017 0.0103 0.0103
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0183
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0103 0.0271
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0076 0.0811 0.0811
Brugia malayi putative neuropeptide receptor 0.0017 0.0103 0.015
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.053 0.0798
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Onchocerca volvulus 0.0017 0.0103 0.0271
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0315 0.1074
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0103 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0229 0.2639 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0229 0.2639 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0015 0.0074 0.028
Schistosoma mansoni opsin-like receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis copper transporting ATPase 1 0.0011 0.0025 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1266 0.4594
Echinococcus multilocularis cation transporting atpase worm 0.0011 0.0025 0.0025
Loa Loa (eye worm) DNA-directed RNA polymerase II second largest subunit 0.0013 0.0054 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0183
Leishmania major P-type H -ATPase, putative 0.0022 0.0156 0.0557
Giardia lamblia Kinase, PLK 0.0091 0.0991 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0296 0.3449 0.3449
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0103 0.0103
Echinococcus granulosus expressed protein 0.037 0.4343 0.4343
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0229 0.2639 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.238 0.3605
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0011 0.0025 0.0025
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0103 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0195 0.0214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Trypanosoma brucei DNA-directed RNA polymerase III, putative 0.0013 0.0054 0.017
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0136 0.0141
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0027 0.0223 0.0844
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1266 0.1266
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0941 0.3391
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0315 0.1162
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0034 0.0305 0.1153
Entamoeba histolytica hypothetical protein 0.0019 0.0124 0.08
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1266 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0579 0.0699
Onchocerca volvulus 0.0083 0.0893 0.3203
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1266 0.4594
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0991 0.3754
Schistosoma mansoni ATPase 0.0034 0.0305 0.0305
Brugia malayi Membrane calcium atpase protein 3 0.0027 0.0223 0.0333
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0103 0.015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0119 0.0119
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0128 0.0128
Schistosoma mansoni adenoreceptor 0.0017 0.0103 0.0103
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0027 0.0223 0.0223
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0266 0.0892
Echinococcus granulosus sex peptide receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis zinc finger protein 0.0009 0.0004 0.0004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0692 0.7326
Echinococcus granulosus DNA directed RNA polymerase II subunit RPB2 0.0013 0.0054 0.0054
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0103 0.0103
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0114 0.1266 0.4219
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0124 0.0183
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0119 0.0119
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0305 0.1036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus granulosus lamin 0.0053 0.053 0.053
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0052 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0991 0.1498
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0195 0.0704
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0103 0.0103
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0127 0.1422 0.1422
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0136 0.0167
Leishmania major calcium motive p-type ATPase, putative 0.0027 0.0223 0.0812
Giardia lamblia DNA-directed RNA polymerase RPB2 0.0013 0.0054 0.0455
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0229 0.2639 1
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0027 0.0223 0.0812
Echinococcus multilocularis serotonin receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Onchocerca volvulus 0.0021 0.0144 0.0426
Echinococcus granulosus neuropeptide receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0175
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0034 0.0305 0.0372
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0103
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0119 0.0145
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0027 0.0223 0.2294
Brugia malayi neuropeptide F receptor 0.0017 0.0103 0.015
Echinococcus granulosus cation transporting ATPase 13A3 0.0011 0.0025 0.0025
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0127 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0052 0.0195
Trichomonas vaginalis DNA-directed RNA polymerase I subunit, putative 0.0013 0.0054 0.0108
Trypanosoma cruzi DNA-directed RNA polymerase III, putative 0.0013 0.0054 0.0204
Echinococcus granulosus somatostatin receptor 0.0017 0.0103 0.0103
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0034 0.0305 0.1153
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0076 0.0811 0.0811
Brugia malayi G-protein coupled receptor 0.0017 0.0103 0.015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.1785 0.2703
Onchocerca volvulus 0.0017 0.0103 0.0271
Echinococcus multilocularis nervana 2 0.0207 0.238 0.238
Onchocerca volvulus 0.0207 0.238 0.8716
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0259 0.0259
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0027 0.0223 0.0223
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0259 0.0259
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0103 0.0103
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0083 0.0893 0.135
Schistosoma mansoni ATPase 0.0034 0.0305 0.0305
Brugia malayi G protein-coupled receptor 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.008 0.0856 0.1293
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0136 0.1292
Loa Loa (eye worm) DNA-directed RNA polymerase 0.0011 0.0026 0.0034
Brugia malayi hypothetical protein 0.0021 0.0144 0.0213
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0103 0.015
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0315 0.0315
Schistosoma mansoni lipoxygenase 0.0021 0.0144 0.0144
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0128 0.0188
Echinococcus multilocularis sex peptide receptor 0.0017 0.0103 0.0103
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.01
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0103 0.0103
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0207 0.238 0.238
Schistosoma mansoni alpha-glucosidase 0.0135 0.1522 0.1522
Onchocerca volvulus 0.0127 0.1422 0.5166
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0034 0.0305 0.2256
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0019 0.0126 0.0816
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0315 0.1074
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0027 0.0223 0.0223
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0991 0.3577
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0195 0.0214
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0256 0.2966 1
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0011 0.0025 0.0032
Schistosoma mansoni 6-phosphofructokinase 0.0114 0.1266 0.1266
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0128 0.0128
Schistosoma mansoni hypothetical protein 0.0067 0.0698 0.0698
Echinococcus granulosus nervana 2 0.0127 0.1422 0.1422
Leishmania major P-type H -ATPase, putative 0.0022 0.0156 0.0557
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1266 0.1915
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0207 0.238 0.238
Trypanosoma cruzi P-type H+-ATPase, putative 0.0022 0.0156 0.059
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0107
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0883 0.0883
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0175
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0052 0.0083
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0854 0.1063
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0052 0.0073
Echinococcus granulosus hypothetical protein 0.0017 0.0103 0.0103
Echinococcus multilocularis expressed protein 0.037 0.4343 0.4343
Brugia malayi hypothetical protein 0.0019 0.0124 0.0183
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0103 0.0103
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0124 0.0124
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.01
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0195 0.0577
Trypanosoma cruzi P-type H+-ATPase, putative 0.0022 0.0156 0.059
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0671 0.7951 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Echinococcus granulosus 6 phosphofructokinase 0.0114 0.1266 0.1266
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0611 0.7224 0.9082
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0103 0.015
Schistosoma mansoni cpg binding protein 0.0031 0.0263 0.0263
Plasmodium vivax DNA-directed RNA polymerase II subunit RPB2, putative 0.0013 0.0054 0.0063
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0266 0.033
Schistosoma mansoni hypothetical protein 0.0164 0.1861 0.1861
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0034 0.0305 0.1123
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0072 0.0762 0.1151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0103 0.0103
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0103 0.0103
Schistosoma mansoni bromodomain containing protein 0.0009 0.0004 0.0004
Onchocerca volvulus 0.0017 0.0103 0.0271
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0136 0.0482
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0103 0.0103
Trypanosoma brucei calpain-like protein, putative 0.0229 0.2639 1
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0991 0.0991
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0941 0.1179
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0491 0.5785 0.8773
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0127 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0053 0.053 0.0798
Giardia lamblia DNA-directed RNA polymerase subunit B 0.0013 0.0054 0.0455
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0185 0.0275
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0015 0.0074 0.0399
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0256 0.2966 0.3711
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0034 0.0305 0.3009
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Schistosoma mansoni neuropeptide receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0034 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0579 0.0579
Brugia malayi follicle stimulating hormone receptor 0.0491 0.5785 0.8773
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1266 0.4795
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0103 0.015
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0103 0.0103
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0103 0.015
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0103 0.015
Onchocerca volvulus 0.0017 0.0103 0.0271
Entamoeba histolytica fatty acid elongase, putative 0.0087 0.0942 0.739
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0315 0.1192
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0103 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1266 0.4594
Onchocerca volvulus 0.0025 0.0195 0.0612
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0305 0.2256
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0671 0.7951 1
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0063 0.0646 0.0784
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0266 0.0323
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0027 0.0223 0.0223
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0315 0.3281
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0103 0.0103
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0671 0.7951 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0124 0.0368
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0103 0.0103
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0124 0.0368
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0073
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0229 0.2639 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0124 0.0124
Schistosoma mansoni DNA-directed rna polymerase II subunit 0.0013 0.0054 0.0054
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0103 0.0103
Plasmodium falciparum DNA-directed RNA polymerase III subunit RPC2, putative 0.0013 0.0054 0.0056
Brugia malayi Na,K-ATPase alpha subunit 0.0083 0.0893 0.135
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0229 0.2639 1
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Brugia malayi bZIP transcription factor family protein 0.0082 0.0883 0.1334
Schistosoma mansoni neuropeptide receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0061 0.0633 0.0955
Schistosoma mansoni kinase 0.0046 0.0452 0.0452
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0671 0.7951 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0136 0.0898
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0114 0.1266 0.1566
Brugia malayi ORL1-like opioid receptor 0.0017 0.0103 0.015
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0103 0.0103
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0034 0.0305 0.3171
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0128 0.0188
Brugia malayi calcium ATPase 0.0012 0.0044 0.0062
Echinococcus multilocularis RUN 0.0021 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0103 0.015
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0235 0.0351
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0052 0.01
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0202 0.0202
Echinococcus multilocularis dnaJ subfamily B 0.0842 1 1
Brugia malayi Pre-SET motif family protein 0.003 0.0259 0.0388
Leishmania major calcium-translocating P-type ATPase 0.0034 0.0305 0.1123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Plasmodium vivax cation transporting ATPase, putative 0.0011 0.0025 0.0026
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0103 0.0103
Onchocerca volvulus 0.0017 0.0103 0.0271
Schistosoma mansoni cpg binding protein 0.0032 0.0284 0.0284
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0195 0.0214
Schistosoma mansoni biogenic amine receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis DNA directed RNA polymerase III subunit RPC2 0.0013 0.0054 0.0054
Echinococcus granulosus DNA directed RNA polymerase I subunit RPA2 0.0013 0.0054 0.0054
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0305 0.2256
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0438 0.153
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0027 0.0223 0.0333
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0305 0.1036
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0124 0.0124
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0052 0.0162
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0124 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0229 0.2639 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0144 0.0144
Echinococcus granulosus cation transporting atpase worm 0.0011 0.0025 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0195 0.0214
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0103 0.0103
Brugia malayi 6-phosphofructokinase 0.0114 0.1266 0.1915
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0533 0.0803
Brugia malayi hypothetical protein 0.0065 0.0671 0.1012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0195 0.1368
Schistosoma mansoni hypothetical protein 0.0164 0.1861 0.1861
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0103 0.0103
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0991 0.3566
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0305 0.1036
Echinococcus granulosus g protein coupled receptor 0.0017 0.0103 0.0103
Trypanosoma brucei cation-transporting ATPase, putative 0.0011 0.0025 0.0059
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0103 0.0103
Echinococcus granulosus microtubule associated protein 2 0.0676 0.8006 0.8006
Toxoplasma gondii DNA-directed RNA polymerase II RPB2 0.0013 0.0054 0.048
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0136 0.0141
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0124 0.0183
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0883 0.0883
Brugia malayi Serotonin receptor 0.0017 0.0103 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0991 0.3577
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0124 0.0124
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0991 0.1498
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0103 0.0103
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0266 0.2754
Brugia malayi PXA domain containing protein 0.0019 0.0124 0.0183
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0016 0.0092 0.0134
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0103 0.0103
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0238 0.0238
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0671 0.7951 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0103 0.0103
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1785 0.1785
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0175
Loa Loa (eye worm) intermediate filament protein 0.0053 0.053 0.0798
Echinococcus multilocularis lamin dm0 0.0053 0.053 0.053
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0256 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.0175
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Brugia malayi hypothetical protein 0.0021 0.0144 0.0213
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0103 0.0103
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0023 0.0173 0.0188
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0034 0.0305 0.1036
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0266 0.2754
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0124 0.0124
Toxoplasma gondii P-type ATPase4, putative 0.0034 0.0305 0.3171
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0235 0.0351
Leishmania major DNA-directed RNA polymerase polypeptide, putative 0.0013 0.0054 0.017
Schistosoma mansoni lamin 0.0053 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0103 0.0103
Echinococcus granulosus jun protein 0.0082 0.0883 0.0883
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0124 0.0183
Echinococcus granulosus copper transporting ATPase 1 0.0011 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0124 0.0368
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0305 0.1036
Trichomonas vaginalis phosphofructokinase, putative 0.0114 0.1266 0.4594
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0136 0.016
Trypanosoma cruzi P-type H+-ATPase, putative 0.0015 0.0074 0.028
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0124 0.0124
Echinococcus granulosus g protein coupled receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0035
Echinococcus multilocularis DNA directed RNA polymerase I subunit RPA2 0.0013 0.0054 0.0054
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0229 0.2639 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni myosin xvIII 0.0017 0.0103 0.0103
Brugia malayi intermediate filament protein 0.0053 0.053 0.0798
Plasmodium falciparum copper-transporting ATPase 0.0011 0.0025 0.0019
Leishmania major P-type ATPase, putative 0.0027 0.0223 0.0812
Echinococcus multilocularis somatostatin receptor 0.0017 0.0103 0.0103
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0128 0.0188
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0136 0.0136
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2726 1
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0103 0.0103
Onchocerca volvulus 0.0091 0.0988 0.3556
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0103
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0103 0.0103
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0103 0.0103
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0266 0.0304
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0183
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0144 0.0144
Plasmodium falciparum DNA-directed RNA polymerase II subunit RPB2, putative 0.0013 0.0054 0.0056
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0011 0.0025 0.0025
Echinococcus multilocularis musashi 0.0053 0.053 0.053
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0592 0.0592
Brugia malayi sulfakinin receptor protein 0.0017 0.0103 0.015
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0136 0.0413
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0103 0.0103
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0207 0.238 0.238
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0305 0.1036
Onchocerca volvulus 0.0017 0.0103 0.0271
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0034 0.0305 0.0305
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.0305 0.1036
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0315 0.1074
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0195 0.0214
Brugia malayi Pre-SET motif family protein 0.0207 0.2383 0.3611
Onchocerca volvulus 0.0017 0.0103 0.0271
Trypanosoma cruzi RNA polymerase I second largest subunit, putative 0.0009 0.0009 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0144 0.0213
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0103 0.0103
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0011 0.0025 0.0157
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0315 0.0472
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0124 0.0124
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0266 0.2613
Schistosoma mansoni opsin-like receptor 0.0017 0.0103 0.0103
Brugia malayi acetyltransferase, GNAT family protein 0.0296 0.3449 0.5229
Brugia malayi CXXC zinc finger family protein 0.0031 0.0263 0.0393
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0103 0.0103
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0266 0.0304
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0011 0.0025 0.0032
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0315 0.1074
Trypanosoma brucei P-type H+-ATPase, putative 0.0022 0.0156 0.0557
Schistosoma mansoni alpha-glucosidase 0.0135 0.1522 0.1522
Loa Loa (eye worm) hypothetical protein 0.0025 0.019 0.0283
Leishmania major calcium-transporting ATPase, putative 0.0027 0.0223 0.0812
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.007 0.073 0.0908
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0579 0.0579
Echinococcus multilocularis nervana 2 0.0127 0.1422 0.1422
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Giardia lamblia Copper-transporting P-type ATPase 0.0011 0.0025 0.0157
Onchocerca volvulus 0.0017 0.0103 0.0271
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0034 0.0305 0.1153
Trypanosoma brucei calcium-transporting ATPase, putative 0.0016 0.0092 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni lipoxygenase 0.0058 0.0592 0.0592
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.029
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.8006 0.8006
Entamoeba histolytica fatty acid elongase, putative 0.0087 0.0942 0.739
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0027 0.0223 0.0734
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0266 0.0892
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0136 0.0482
Brugia malayi Dopamine receptor 0.0017 0.0103 0.015
Trypanosoma brucei hypothetical protein 0.0229 0.2639 1
Toxoplasma gondii P-type ATPase PMA1 0.0022 0.0156 0.1574
Brugia malayi Doublecortin family protein 0.0021 0.0144 0.0213
Trypanosoma brucei DNA-directed RNA polymerase II subunit 2, putative 0.0013 0.0054 0.017
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0019 0.0126 0.0816
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0259 0.0259
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0124 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0991 0.3577
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0103 0.0103
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0103 0.0103
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis nervana 2 0.0127 0.1422 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0124 0.0368
Schistosoma mansoni rab6-interacting 0.0021 0.0144 0.0144
Trypanosoma cruzi cation-transporting ATPase, putative 0.0011 0.0025 0.0093
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0034 0.0305 0.0305
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0103 0.0103
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0195 0.0577
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0103 0.0103
Entamoeba histolytica hypothetical protein 0.0019 0.0124 0.08
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0025 0.019 0.0283
Echinococcus multilocularis geminin 0.0164 0.1861 0.1861
Echinococcus granulosus g protein coupled receptor 0.0017 0.0103 0.0103
Echinococcus granulosus cpg binding protein 0.0032 0.0284 0.0284
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Echinococcus granulosus histone acetyltransferase KAT2B 0.0288 0.335 0.335
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0941 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0103 0.015
Plasmodium vivax calcium-transporting ATPase, putative 0.0034 0.0305 0.0379
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0263 0.0393
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0991 0.7786
Echinococcus granulosus neuropeptide receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.0092 0.0134
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0315 0.1074
Brugia malayi E1-E2 ATPase family protein 0.0011 0.0025 0.0032
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0027 0.0223 0.0223
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0034 0.0305 0.2256
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0136 0.0413
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0259 0.0259
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.1785 0.2703
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0124 0.0124
Toxoplasma gondii DNA-directed RNA polymerase III RPC2 0.0013 0.0054 0.048
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0127 0.1422 0.1422
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0124 0.0124
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0027 0.0223 0.0223
Echinococcus multilocularis lamin 0.0053 0.053 0.053
Brugia malayi neuropeptide F receptor 0.0017 0.0103 0.015
Brugia malayi NC domain containing protein 0.0041 0.0382 0.0574
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0941 1
Schistosoma mansoni neuropeptide receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0124 0.0124
Echinococcus granulosus allatostatin A receptor 0.0017 0.0103 0.0103
Schistosoma mansoni DNA-directed RNA polymerase I subunit 0.0009 0.0009 0.0009
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0114 0.1266 0.4219
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0266 0.1942
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.01
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0266 0.0323
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni cation-transporting atpase worm 0.0011 0.0025 0.0025
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0103 0.0103
Schistosoma mansoni rab6-interacting 0.0021 0.0144 0.0144
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0144 0.0177
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0103 0.015
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0195 0.1368
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0072 0.0762 0.2506
Echinococcus granulosus nervana 2 0.0207 0.238 0.238
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0991 0.3577
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0124 0.0124
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0103 0.0103
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0103 0.0103
Schistosoma mansoni loxhd1 0.0021 0.0144 0.0144
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0034 0.0305 0.0305
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0124 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Onchocerca volvulus 0.0017 0.0103 0.0271
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0103 0.0103
Brugia malayi Melatonin receptor type 1A 0.0017 0.0103 0.015
Schistosoma mansoni hypothetical protein 0.0842 1 1
Brugia malayi hypothetical protein 0.0121 0.1346 0.2037
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0315 0.1074
Echinococcus multilocularis calcium transporting atpase 0.0027 0.0223 0.0223
Schistosoma mansoni biogenic amine receptor 0.0017 0.0103 0.0103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0259 0.0259
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0103 0.0103
Brugia malayi phosphofructokinase 0.0114 0.1266 0.1915
Echinococcus multilocularis cpg binding protein 0.0032 0.0284 0.0284
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0195 0.1368
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0315 0.2338
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0195 0.0214
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0124 0.0183
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0052 0.01
Schistosoma mansoni cation-transporting atpase worm 0.0011 0.0025 0.0025
Echinococcus granulosus cation transporting ATPase 13A1 0.0011 0.0025 0.0025
Echinococcus multilocularis DNA directed RNA polymerase II subunit RPB2 0.0013 0.0054 0.0054
Brugia malayi Serotonin receptor 0.0017 0.0103 0.015
Onchocerca volvulus 0.0065 0.0671 0.2378
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0103 0.0103
Schistosoma mansoni opsin-like receptor 0.0017 0.0103 0.0103
Onchocerca volvulus 0.0017 0.0103 0.0271
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0315 0.1074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0107 0.0103
Trypanosoma brucei calpain, putative 0.0229 0.2639 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0114 0.1266 0.1566
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0259 0.0259
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0009 0.0004 0.0004
Echinococcus granulosus geminin 0.0164 0.1861 0.1861
Schistosoma mansoni lamin 0.0053 0.053 0.053
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0017 0.0103 0.0103
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0103 0.0103
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0103 0.015
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.01
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0103 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Brugia malayi DNA-directed RNA polymerase, beta subunit family protein 0.0013 0.0054 0.0076
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0019 0.0126 0.0186
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0195 0.0214
Brugia malayi GnHR receptor homolog 0.0017 0.0103 0.015
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0052 0.0162
Loa Loa (eye worm) E1-E2 ATPase 0.0022 0.0156 0.0231
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0136 0.0201
Entamoeba histolytica fatty acid elongase, putative 0.0087 0.0942 0.739
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0579 0.0699
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0027 0.0223 0.0223
Loa Loa (eye worm) RNA polymerase III 128kD subunit-PA 0.0013 0.0054 0.0076
Echinococcus granulosus orexin receptor type 2 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0183
Brugia malayi E1-E2 ATPase family protein 0.0022 0.0156 0.0231
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2383 0.3611
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0103 0.0103
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0124 0.0124
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0136 0.0515
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0103 0.0103
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0484 0.0729
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0315 0.0472
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0015 0.0074 0.0107
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0229 0.2639 1
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0266 0.2754
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0119 0.0119
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0015 0.0074 0.028
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0671 0.7951 1
Brugia malayi RE15519p 0.0017 0.0103 0.015
Onchocerca volvulus 0.0053 0.053 0.1855
Echinococcus granulosus nervana 2 0.0207 0.238 0.238
Echinococcus granulosus zinc finger protein 0.0009 0.0004 0.0004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0229 0.2639 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0259 0.2684
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0144 0.0144
Loa Loa (eye worm) calcium ATPase 0.0019 0.0126 0.0186
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0022
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0124 0.0124
Onchocerca volvulus 0.0021 0.0144 0.0426
Schistosoma mansoni ap endonuclease 0.002 0.0136 0.0136
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0136 0.0379
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0266 0.0892
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0207 0.238 0.238
Schistosoma mansoni copper ABC transporter ATPase 0.0011 0.0025 0.0025
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0144 0.0213
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0114 0.1266 0.4777
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0941 0.0941
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0136 0.0515
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0991 0.0991
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0991 0.0991
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0103 0.015
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0011 0.0025 0.0093
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1785 0.1785
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0124 0.0124
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0259 0.0259
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0124 0.0124
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0103 0.0103
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0103 0.0103
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0103 0.0103
Echinococcus granulosus RUN 0.0021 0.0144 0.0144
Onchocerca volvulus 0.0236 0.2726 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.3675 0.5571
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0034 0.0305 0.3171
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0124 0.0124
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0016 0.0092 0.0347
Loa Loa (eye worm) hypothetical protein 0.0034 0.0305 0.0457
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0022 0.0028
Echinococcus multilocularis 6 phosphofructokinase 0.0114 0.1266 0.1266
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0011 0.0025 0.0093
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0025 0.0202 0.03
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0305 0.1036
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0103 0.0103
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0083 0.0893 0.1095
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0011 0.0025 0.0166
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0207 0.238 0.238
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0083 0.0893 0.0893
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0195 0.0704
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0013 0.0054 0.0054
Toxoplasma gondii hypothetical protein 0.0041 0.0382 0.3999
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0107 0.0103
Loa Loa (eye worm) hypothetical protein 0.006 0.0613 0.0925
Schistosoma mansoni cation-transporting ATPase 0.0011 0.0025 0.0025
Schistosoma mansoni alpha glucosidase 0.0035 0.0315 0.0315
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0128 0.0128
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0266 0.0892
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Leishmania major ATP-dependent phosphofructokinase 0.0114 0.1266 0.4777
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0083 0.0893 0.135
Schistosoma mansoni hypothetical protein 0.0021 0.0144 0.0144
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0315 0.0315
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0991 0.3577
Brugia malayi hypothetical protein 0.0017 0.0103 0.015
Brugia malayi small heat shock protein 0.0558 0.6594 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0195 0.029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0688 0.0688
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0991 0.3754
Brugia malayi G-protein coupled receptor 0.0017 0.0103 0.015
Trypanosoma brucei glucosidase, putative 0.0035 0.0315 0.1162
Plasmodium vivax DNA-directed RNA polymerase I subunit RPA2, putative 0.0009 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus multilocularis cation transporting ATPase 13A1 0.0011 0.0025 0.0025
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0103 0.015
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0015 0.0074 0.0107
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0144 0.017
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0103 0.0103
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0266 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0124 0.0368
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0124 0.0124
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0124 0.0183
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0103 0.0103
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0315 0.1074
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0103 0.0103
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0124 0.0124
Brugia malayi 6-phosphofructokinase 0.0114 0.1266 0.1915
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0103 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0991 0.3577
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.01
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0124 0.0124
Echinococcus granulosus calcium transporting atpase 0.0027 0.0223 0.0223
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0266 0.0892
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0103 0.0103
Schistosoma mansoni intermediate filament proteins 0.0053 0.053 0.053
Echinococcus multilocularis cation transporting ATPase 13A3 0.0011 0.0025 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0315 0.1192
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0103 0.015
Echinococcus granulosus DNA directed RNA polymerase III subunit RPC2 0.0013 0.0054 0.0054
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0195 0.0214
Entamoeba histolytica DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide, putative 0.0013 0.0054 0.0236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0296 0.3449 0.3449
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0103 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Onchocerca volvulus UPF0528 protein homolog 0.0041 0.0382 0.1307
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0266 0.0892
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0207 0.238 0.238
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0124 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0266 0.0892
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0035
Onchocerca volvulus 0.003 0.0259 0.0853
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0034 0.0305 0.0305
Schistosoma mansoni amine GPCR 0.0017 0.0103 0.0103
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0103 0.0103
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0144 0.0144
Trypanosoma brucei calcium-translocating P-type ATPase 0.0027 0.0223 0.0812
Echinococcus granulosus Na:K ATPase alpha subunit 0.0076 0.0811 0.0811
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0195 0.029
Schistosoma mansoni neuropeptide receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0183
Entamoeba histolytica DNA-directed RNA polymerase subunit, putative 0.0013 0.0054 0.0236
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0103 0.0103
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0136 0.0136
Leishmania major proton motive ATPase, putative 0.0011 0.0025 0.0059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Trypanosoma brucei polo-like protein kinase 0.0091 0.0991 0.3733
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0266 0.033
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0034 0.0305 0.0353
Entamoeba histolytica hypothetical protein 0.0019 0.0124 0.08
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0034 0.0305 0.1036
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0103 0.0103
Toxoplasma gondii exonuclease III APE 0.002 0.0136 0.1362
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0854 0.8601
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0229 0.2639 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0041 0.0382 0.0574
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0124 0.0124
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0229 0.2639 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.0183
Echinococcus granulosus lamin dm0 0.0053 0.053 0.053
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0124 0.0183
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0119 0.0138
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0854 0.6679
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0991 0.3577
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0021 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0032
Mycobacterium ulcerans hypothetical protein 0.0025 0.0195 0.0214
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0072 0.0762 0.1151
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0103 0.0103
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0103 0.0103
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.1785 0.1785
Onchocerca volvulus 0.0017 0.0103 0.0271
Brugia malayi hypothetical protein 0.0019 0.0124 0.0183
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0012 0.0044 0.0167
Loa Loa (eye worm) hypothetical protein 0.0025 0.0195 0.029
Schistosoma mansoni DNA-directed RNA polymerase III subunit 0.0013 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Onchocerca volvulus 0.0017 0.0103 0.0271
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0103 0.0103
Loa Loa (eye worm) 6-phosphofructokinase 0.0114 0.1266 0.1915
Echinococcus granulosus intermediate filament protein 0.0053 0.053 0.053
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0207 0.238 0.238
Onchocerca volvulus 0.0053 0.053 0.1855
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0103 0.0103
Echinococcus granulosus fmrfamide receptor 0.0017 0.0103 0.0103
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0941 0.3391
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0195 0.0704
Schistosoma mansoni cpg binding protein 0.0032 0.0284 0.0284
Entamoeba histolytica phosphofructokinase, putative 0.0114 0.1266 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0103 0.015
Schistosoma mansoni polycystin 1-related 0.0021 0.0144 0.0144
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0103 0.015
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0144 0.0144

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 27 % Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment at 10 uM incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay ChEMBL. 23679955
IC50 (binding) = 0.981 uM Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by beta-arrestin translocation assay ChEMBL. 23679955
IC50 (binding) > 10 uM Antagonist activity at human GPR18 transfected in CHO cells assessed as delta9-THC-induced beta-arrestin recruitment incubated 60 mins prior to delta9-THC addition by beta-arrestin translocation assay ChEMBL. 23679955
Kb (binding) = 1.87 uM Antagonist activity at human GPR55 transfected in CHO cells assessed as inhibition of LPI-induced beta-arrestin recruitment incubated 60 mins prior to LPI addition by Schild regression method ChEMBL. 23679955
Ki (binding) = 0.338 uM Displacement of [3H]-CP55,940 from human CB2 receptor transfected in CHOK1 cells ChEMBL. 23679955
Ki (binding) = 3.66 uM Displacement of [3H]-CP55,940 from human CB1 receptor transfected in CHOK1 cells ChEMBL. 23679955

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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