TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 514.4 | Formula: C26H25Cl2N3O4
H donors: 1 H acceptors: 3 LogP: 6.4 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: CO/C=C(\c1ccccc1COc1nc(nc2c1CCCC2)Nc1cccc(c1Cl)Cl)/C(=O)OC
InChi: 1S/C26H25Cl2N3O4/c1-33-15-19(25(32)34-2)17-9-4-3-8-16(17)14-35-24-18-10-5-6-12-21(18)29-26(31-24)30-22-13-7-11-20(27)23(22)28/h3-4,7-9,11,13,15H,5-6,10,12,14H2,1-2H3,(H,29,30,31)/b19-15+
InChiKey: JMPRYEXMGOWJBW-XDJHFCHBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0385	0.0681
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0385	0.0244
Plasmodium vivax	vivapain-2	0.0053	0.0982	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0385	0.0244
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Loa Loa (eye worm)	calpain family protein 1	0.0033	0.0195	0.0195
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0053	0.0982	0.085
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0385	0.0244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Toxoplasma gondii	cathepsin B	0.01	0.2798	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0385	0.0244
Loa Loa (eye worm)	cathepsin B	0.01	0.2798	0.2798
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Loa Loa (eye worm)	cysteine protease	0.0053	0.0982	0.0982
Onchocerca volvulus		0.0038	0.0385	0.0681
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.0982	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0982	0.0982
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0385	0.0244
Brugia malayi	AKH receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Echinococcus multilocularis	calpain family protein 1, d	0.0033	0.0195	0.0051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Onchocerca volvulus		0.0038	0.0385	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0385	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.0982	1
Onchocerca volvulus		0.0038	0.0385	0.0681
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0286	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0385	0.0244
Brugia malayi	GnHR receptor homolog	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	hypothetical protein	0.0038	0.0385	0.0244
Brugia malayi	calpain family protein 1	0.0044	0.0647	0.051
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0385	0.0244
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.0982	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Brugia malayi	G protein-coupled receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0385	0.0244
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Brugia malayi	larval opioid receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	cathepsin l1	0.0053	0.0982	0.085
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.0982	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0411	0.1005
Onchocerca volvulus		0.0038	0.0385	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Brugia malayi	cathepsin L-like precursor	0.0038	0.0411	0.0271
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0411	0.0271
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0385	0.0244
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0385	0.0244
Onchocerca volvulus		0.0038	0.0385	0.0681
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.01	0.2798	0.2692
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Trypanosoma brucei	cysteine peptidase C (CPC)	0.01	0.2798	1
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0385	0.0244
Onchocerca volvulus		0.0038	0.0385	0.0681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0038	0.0411	0.1005
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Onchocerca volvulus		0.0053	0.0982	0.1738
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0174	0.5652	0.5588
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Onchocerca volvulus		0.0038	0.0385	0.0681
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.0982	0.085
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0982	0.085
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0053	0.0982	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0385	0.0244
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0385	0.0244
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0385	0.0244
Brugia malayi	G-protein coupled receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0385	0.0244
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.01	0.2798	0.2692
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0982	0.085
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0046	0.0725	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Onchocerca volvulus		0.0038	0.0385	0.0681
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0453	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0982	0.085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0046	0.0725	0.0589
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0385	0.0244
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0982	0.085
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0046	0.0725	0.0589
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0385	0.0385
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.0982	0.085
Loa Loa (eye worm)	ctsf protein	0.0053	0.0982	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.0982	0.085
Onchocerca volvulus	Cathepsin F homolog	0.0053	0.0982	0.1738
Onchocerca volvulus		0.0053	0.0982	0.1738
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	fibroinase	0.0053	0.0982	0.0982
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0046	0.0725	0.0589
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	calpain A	0.0046	0.0725	0.0589
Entamoeba histolytica	cysteine proteinase, putative	0.0038	0.0411	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0385	0.0244
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0982	0.085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0385	0.0244
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0385	0.0244
Onchocerca volvulus		0.0053	0.0982	0.1738
Schistosoma mansoni	hypothetical protein	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0385	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Brugia malayi	Dopamine receptor protein 1	0.0038	0.0385	0.0244
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0385	0.0244
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0286	1	1
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Schistosoma mansoni	amine GPCR	0.0038	0.0385	0.0244
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0411
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Schistosoma mansoni	cathepsin F (C01 family)	0.0038	0.0411	0.0271
Schistosoma mansoni	amine GPCR	0.0038	0.0385	0.0244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Schistosoma mansoni	myosin xvIII	0.0038	0.0385	0.0244
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0385	0.0244
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.0982	0.085
Loa Loa (eye worm)	hypothetical protein	0.0286	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0385	0.0244
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0385	0.0244
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0385	0.0244
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0411	0.0411
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Plasmodium vivax	vivapain-2	0.0053	0.0982	1
Giardia lamblia	Cathepsin B precursor	0.01	0.2798	0.5
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.01	0.2798	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0385	0.0385
Echinococcus multilocularis	cysteine protease	0.0053	0.0982	0.085
Schistosoma mansoni	amine GPCR	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0385	0.0244
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.0982	0.1738
Onchocerca volvulus		0.0053	0.0982	0.1738
Echinococcus multilocularis	cathepsin b	0.0286	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Schistosoma mansoni	amine GPCR	0.0038	0.0385	0.0244
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Giardia lamblia	Cathepsin B precursor	0.01	0.2798	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Schistosoma mansoni	amine GPCR	0.0038	0.0385	0.0244
Giardia lamblia	Cathepsin B precursor	0.01	0.2798	0.5
Schistosoma mansoni	hypothetical protein	0.0038	0.0385	0.0244
Brugia malayi	putative neuropeptide receptor	0.0038	0.0385	0.0244
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0982	0.085
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0053	0.0982	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0385	0.0244
Schistosoma mansoni	opsin-like receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0385	0.0244
Brugia malayi	Serotonin receptor	0.0038	0.0385	0.0244
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0385	0.0244
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0286	1	1
Echinococcus granulosus	hypothetical protein	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0385	0.0244
Brugia malayi	Cathepsin L-like precursor	0.0038	0.0411	0.0271
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0286	1	1
Onchocerca volvulus		0.0038	0.0385	0.0681
Schistosoma mansoni	opsin-like receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	adenoreceptor	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0038	0.0411	0.0271
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Echinococcus granulosus	cathepsin l1	0.0038	0.0411	0.0271
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Onchocerca volvulus		0.0174	0.5652	1
Echinococcus multilocularis	serotonin receptor	0.0038	0.0385	0.0244
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0385	0.0244
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0385	0.0385
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0385	0.0244
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0385	0.0244
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0385	0.0244
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.0982	0.1738
Echinococcus granulosus	serotonin receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0385	0.0385
Brugia malayi	calpain family protein 1	0.0044	0.0647	0.051
Echinococcus granulosus	cathepsin b	0.0286	1	1
Onchocerca volvulus		0.0038	0.0385	0.0681
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Onchocerca volvulus		0.0038	0.0385	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0385	0.0244
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0385	0.0385
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0385	0.0244
Onchocerca volvulus		0.0038	0.0385	0.0681
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0038	0.0411	0.0271
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	hypothetical protein	0.0038	0.0385	0.0244
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.0647	0.0647
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0174	0.5652	0.5652
Brugia malayi	G-protein coupled receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0385	0.0385
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0385	0.0244
Onchocerca volvulus		0.0038	0.0385	0.0681
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0053	0.0982	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0385	0.0244
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0053	0.0982	0.0982
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0385	0.0244
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0385	0.0244
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0385	0.0244
Echinococcus granulosus	sex peptide receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0647	0.0647
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0982	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0385	0.0244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus granulosus	calpain A	0.0046	0.0725	0.0589
Brugia malayi	neuropeptide F receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0647	0.051
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0385	0.0244
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0982	0.0982
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0385	0.0244
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.0982	0.085
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0053	0.0982	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0385	0.0244
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0385	0.0244
Schistosoma mansoni	opsin-like receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0385	0.0244
Echinococcus multilocularis	cathepsin b	0.0286	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0385	0.0244
Brugia malayi	Serotonin receptor	0.0038	0.0385	0.0244
Onchocerca volvulus		0.0038	0.0385	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Onchocerca volvulus		0.0053	0.0982	0.1738
Brugia malayi	neuropeptide F receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0385	0.0244
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0385	0.0244
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.0982	0.085
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Echinococcus multilocularis	cysteine protease	0.0053	0.0982	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.01	0.2798	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0053	0.0982	0.3158
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0385	0.0385
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0982	0.085
Brugia malayi	sulfakinin receptor protein	0.0038	0.0385	0.0244
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	serotonin receptor	0.0038	0.0385	0.0244
Brugia malayi	RE15519p	0.0038	0.0385	0.0244
Onchocerca volvulus		0.0053	0.0982	0.1738
Onchocerca volvulus		0.0038	0.0385	0.0681
Trypanosoma cruzi	cruzipain precursor, putative	0.0053	0.0982	0.085
Onchocerca volvulus		0.0038	0.0385	0.0681
Echinococcus multilocularis	allatostatin A receptor	0.0174	0.5652	0.5588
Onchocerca volvulus		0.0038	0.0411	0.0727
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0385	0.0244
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0286	1	1
Onchocerca volvulus		0.0053	0.0982	0.1738
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0385	0.0244
Echinococcus granulosus	cathepsin b	0.0286	1	1
Brugia malayi	hypothetical protein	0.0038	0.0385	0.0244
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0385	0.0385
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0385	0.0244
Echinococcus granulosus	allatostatin A receptor	0.0174	0.5652	0.5588
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0385	0.0244
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0385	0.0244
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.0982	0.085
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0385	0.0244
Brugia malayi	Dopamine receptor	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus granulosus	somatostatin receptor	0.0038	0.0385	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0195	0.0195
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0385	0.0244
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0982	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0385	0.0385
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.0982	0.085

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 1.1 uM	Cytotoxicity against human HL60 cells assessed as growth inhibition by MTT assay	ChEMBL.	23664877

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23664877

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2392681

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1777386