Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | indoleamine 2,3-dioxygenase | 0.2328 | 1 | 1 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.036 | 0.141 | 0.141 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0678 | 0.2798 | 0.2798 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.1293 | 0.5482 | 1 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.015 | 0.0492 | 0.0669 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0093 | 0.0245 | 0.0413 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1459 | 0.1422 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0093 | 0.0245 | 0.0413 |
Echinococcus multilocularis | carbonic anhydrase | 0.0371 | 0.1459 | 0.1459 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.019 | 0.0665 | 0.4004 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0047 | 0.0043 | 0.0043 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.036 | 0.141 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0678 | 0.2798 | 0.2767 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0678 | 0.2798 | 0.2798 |
Leishmania major | farnesyltransferase beta subunit | 0.019 | 0.0665 | 0.199 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.019 | 0.0665 | 0.0625 |
Toxoplasma gondii | hypothetical protein | 0.0267 | 0.1002 | 0.6551 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0371 | 0.1459 | 0.1459 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0093 | 0.0245 | 0.0413 |
Schistosoma mansoni | hypothetical protein | 0.0371 | 0.1459 | 0.1459 |
Echinococcus multilocularis | indoleamine 2,3 dioxygenase 2 | 0.2328 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0371 | 0.1459 | 0.1459 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.019 | 0.0665 | 0.4157 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0585 | 0.2393 | 0.375 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.019 | 0.0665 | 0.0665 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0371 | 0.1459 | 0.1459 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0876 | 0.366 | 0.6348 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0371 | 0.1459 | 0.1459 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0196 | 0.0695 | 0.0695 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0196 | 0.0695 | 0.4391 |
Schistosoma mansoni | hypothetical protein | 0.2328 | 1 | 1 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.0068 | 0.0135 | 0.0135 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0765 | 0.3179 | 0.3179 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0093 | 0.0245 | 0.0413 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0196 | 0.0695 | 0.0695 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.019 | 0.0665 | 0.0665 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.036 | 0.141 | 0.141 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.036 | 0.141 | 1 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.019 | 0.0665 | 0.199 |
Toxoplasma gondii | hypothetical protein | 0.0371 | 0.1459 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0371 | 0.1459 | 0.1459 |
Entamoeba histolytica | Rab geranylgeranyltransferase beta subunit, putative | 0.0068 | 0.0135 | 0.0956 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.019 | 0.0665 | 0.4157 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0585 | 0.2393 | 0.3809 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.019 | 0.0665 | 0.4716 |
Plasmodium falciparum | carbonic anhydrase | 0.0371 | 0.1459 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0093 | 0.0245 | 0.0413 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0093 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0196 | 0.0695 | 0.0655 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.019 | 0.0665 | 0.4004 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0876 | 0.366 | 0.6592 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1459 | 0.1422 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0371 | 0.1459 | 0.1459 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0196 | 0.0695 | 0.0695 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.019 | 0.0665 | 0.4157 |
Toxoplasma gondii | hypothetical protein | 0.0093 | 0.0245 | 0.0832 |
Echinococcus multilocularis | carbonic anhydrase | 0.0371 | 0.1459 | 0.1459 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.1311 | 0.556 | 1 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.036 | 0.141 | 1 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0093 | 0.0245 | 0.0864 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0678 | 0.2798 | 1 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.019 | 0.0665 | 0.4157 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0093 | 0.0245 | 0.0413 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0196 | 0.0695 | 0.0695 |
Echinococcus granulosus | carbonic anhydrase | 0.0371 | 0.1459 | 0.1459 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.019 | 0.0665 | 0.199 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0093 | 0.0245 | 0.0245 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0196 | 0.0695 | 0.0695 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.019 | 0.0665 | 0.199 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0093 | 0.0245 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0135 | 0.0093 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.1293 | 0.5482 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0135 | 0.0093 |
Onchocerca volvulus | 0.0093 | 0.0245 | 0.5 | |
Echinococcus granulosus | carbonic anhydrase II | 0.0678 | 0.2798 | 0.2798 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0678 | 0.2798 | 0.2767 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0196 | 0.0695 | 0.4927 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.0068 | 0.0135 | 0.0135 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0371 | 0.1459 | 0.1459 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.036 | 0.141 | 1 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0093 | 0.0245 | 0.0245 |
Trichomonas vaginalis | conserved hypothetical protein | 0.015 | 0.0492 | 0.2805 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.1311 | 0.556 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0678 | 0.2798 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0876 | 0.366 | 0.6348 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0371 | 0.1459 | 0.1459 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0093 | 0.0245 | 0.0413 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0371 | 0.1459 | 0.1459 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0267 | 0.1002 | 0.6802 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.036 | 0.141 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.1293 | 0.5482 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0093 | 0.0245 | 0.0413 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0678 | 0.2798 | 1 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.019 | 0.0665 | 0.0665 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.141 | 0.1373 |
Giardia lamblia | Prenyltransferase | 0.019 | 0.0665 | 0.4157 |
Echinococcus granulosus | carbonic anhydrase | 0.0371 | 0.1459 | 0.1459 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0093 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.1459 | 0.1422 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0093 | 0.0245 | 0.0245 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0678 | 0.2798 | 0.2798 |
Leishmania major | carbonic anhydrase-like protein | 0.0678 | 0.2798 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0678 | 0.2798 | 0.2798 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.019 | 0.0665 | 0.4157 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.019 | 0.0665 | 0.4157 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0371 | 0.1459 | 0.1459 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.036 | 0.141 | 0.141 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0047 | 0.0043 | 0.0043 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0093 | 0.0245 | 0.0245 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.036 | 0.141 | 0.141 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0093 | 0.0245 | 0.1737 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0093 | 0.0245 | 0.0203 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0093 | 0.0245 | 0.0864 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.036 | 0.141 | 1 |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.0068 | 0.0135 | 0.0135 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.036 | 0.141 | 0.9631 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0093 | 0.0245 | 0.0413 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0678 | 0.2798 | 0.2798 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.019 | 0.0665 | 0.0665 |
Schistosoma mansoni | hypothetical protein | 0.2328 | 1 | 1 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.036 | 0.141 | 0.1373 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0093 | 0.0245 | 0.0832 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.019 | 0.0665 | 0.4157 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0121 | 0.0367 | 0.1823 |
Echinococcus granulosus | indoleamine 23 dioxygenase 2 | 0.2328 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0371 | 0.1459 | 0.1422 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0093 | 0.0245 | 0.0413 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.1311 | 0.556 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0371 | 0.1459 | 0.1459 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.