Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (ADMET) | = 1.9258 uM | Cytotoxicity against human BJ cells after 72 hrs by celltiter-glo assay | ChEMBL. | 23747806 |
EC50 (functional) | = 15.015 uM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in O-positive erythrocytes assessed as parasite growth inhibition after 72 hrs by DNA staining-based assay | ChEMBL. | 23747806 |
EC50 (ADMET) | = 26.0417 uM | Cytotoxicity against human Raji cells after 72 hrs by celltiter-glo assay | ChEMBL. | 23747806 |
PPB (ADMET) | = 74 % | Plasma protein binding in mouse | ChEMBL. | 23747806 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23747806 | |
Plasmodium falciparum | ChEMBL23 | 23747806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.