Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.122 | 0.122 |
Plasmodium vivax | unspecified product | 0.026 | 0.122 | 0.1058 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0663 | 0.3652 | 0.3652 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0834 | 0.4686 | 0.4686 |
Plasmodium vivax | vivapain-1 | 0.0452 | 0.2381 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0574 | 0.3115 | 0.5946 |
Onchocerca volvulus | 0.0834 | 0.4686 | 1 | |
Onchocerca volvulus | 0.0834 | 0.4686 | 1 | |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0452 | 0.2381 | 0.2381 |
Brugia malayi | Cathepsin L-like precursor | 0.0834 | 0.4686 | 0.4686 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0834 | 0.4686 | 1 |
Leishmania major | cathepsin L-like protease | 0.0834 | 0.4686 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0574 | 0.3115 | 0.3115 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0192 | 0.081 | 0.081 |
Onchocerca volvulus | 0.0834 | 0.4686 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0834 | 0.4686 | 0.4686 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0452 | 0.2381 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1713 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0452 | 0.2381 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0452 | 0.2381 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.081 | 0.081 |
Loa Loa (eye worm) | cysteine protease | 0.0834 | 0.4686 | 0.4686 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0663 | 0.3652 | 0.5513 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0834 | 0.4686 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0834 | 0.4686 | 0.4686 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 0.3115 | 0.3115 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0574 | 0.3115 | 0.5946 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0192 | 0.081 | 0.081 |
Onchocerca volvulus | 0.0574 | 0.3115 | 0.619 | |
Schistosoma mansoni | cathepsin s | 0.026 | 0.122 | 0.122 |
Giardia lamblia | Cathepsin B precursor | 0.0663 | 0.3652 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0192 | 0.081 | 0.081 |
Brugia malayi | Cathepsin L-like precursor | 0.0834 | 0.4686 | 0.4686 |
Trypanosoma cruzi | cysteine protease, putative | 0.0452 | 0.2381 | 0.171 |
Echinococcus multilocularis | cathepsin L | 0.0452 | 0.2381 | 0.2381 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0834 | 0.4686 | 0.4686 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.026 | 0.122 | 0.0446 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0663 | 0.3652 | 0.3093 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0192 | 0.081 | 0.081 |
Onchocerca volvulus | Cathepsin L homolog | 0.0834 | 0.4686 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0834 | 0.4686 | 0.4686 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.0673 | 0.0673 |
Echinococcus granulosus | cathepsin L | 0.0452 | 0.2381 | 0.2381 |
Brugia malayi | Cathepsin L-like precursor | 0.0574 | 0.3115 | 0.3115 |
Onchocerca volvulus | 0.0834 | 0.4686 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Echinococcus granulosus | cysteine protease | 0.0452 | 0.2381 | 0.2381 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Onchocerca volvulus | 0.0834 | 0.4686 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0663 | 0.3652 | 1 |
Leishmania major | cathepsin L-like protease | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0663 | 0.3652 | 0.7332 |
Brugia malayi | Cathepsin L-like precursor | 0.026 | 0.122 | 0.122 |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.0192 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0834 | 0.4686 | 0.4686 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0452 | 0.2381 | 0.171 |
Toxoplasma gondii | cathepsin CPL | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0834 | 0.4686 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0452 | 0.2381 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0192 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.122 | 0.122 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0834 | 0.4686 | 0.4686 |
Giardia lamblia | Cathepsin B precursor | 0.0663 | 0.3652 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0574 | 0.3115 | 0.3115 |
Schistosoma mansoni | cathepsin B (C01 family) | 0.0192 | 0.081 | 0.081 |
Brugia malayi | hypothetical protein | 0.0151 | 0.0562 | 0.0562 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.0192 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0562 | 0.0562 |
Leishmania major | cathepsin L-like protease | 0.0834 | 0.4686 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0834 | 0.4686 | 0.4218 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1713 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1713 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0452 | 0.2381 | 0.4054 |
Echinococcus multilocularis | cathepsin b | 0.1713 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0452 | 0.2381 | 0.171 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0574 | 0.3115 | 0.3115 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.081 | 0.081 |
Onchocerca volvulus | 0.0834 | 0.4686 | 1 | |
Echinococcus granulosus | cathepsin b | 0.1713 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0834 | 0.4686 | 1 |
Onchocerca volvulus | 0.0192 | 0.081 | 0.0601 | |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0192 | 0.081 | 0.081 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.026 | 0.122 | 0.0446 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0834 | 0.4686 | 0.4218 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Plasmodium vivax | vivapain-3 | 0.0452 | 0.2381 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0834 | 0.4686 | 0.4686 |
Brugia malayi | Cathepsin L-like precursor | 0.0834 | 0.4686 | 0.4686 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0834 | 0.4686 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0452 | 0.2381 | 0.2381 |
Echinococcus granulosus | cathepsin l1 | 0.0574 | 0.3115 | 0.3115 |
Loa Loa (eye worm) | cathepsin B | 0.0663 | 0.3652 | 0.3652 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0834 | 0.4686 | 0.4686 |
Brugia malayi | Cathepsin L-like precursor | 0.0834 | 0.4686 | 0.4686 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0834 | 0.4686 | 0.4686 |
Loa Loa (eye worm) | fibroinase | 0.0834 | 0.4686 | 0.4686 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Schistosoma mansoni | cathepsin C | 0.0192 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 0.3115 | 0.3115 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0834 | 0.4686 | 0.4686 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0452 | 0.2381 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Schistosoma mansoni | cathepsin S (C01 family) | 0.0192 | 0.081 | 0.081 |
Leishmania major | cathepsin L-like protease | 0.0834 | 0.4686 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0452 | 0.2381 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Echinococcus multilocularis | cathepsin L | 0.0192 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.081 | 0.081 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1713 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.0673 | 0.0673 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0834 | 0.4686 | 0.4218 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1713 | 1 | 1 |
Brugia malayi | cathepsin L precursor | 0.0192 | 0.081 | 0.081 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0452 | 0.2381 | 0.2381 |
Echinococcus granulosus | cathepsin L | 0.0192 | 0.081 | 0.081 |
Onchocerca volvulus | 0.0834 | 0.4686 | 1 | |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0452 | 0.2381 | 0.171 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0834 | 0.4686 | 0.4686 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0834 | 0.4686 | 0.4686 |
Brugia malayi | Cathepsin L-like precursor | 0.0834 | 0.4686 | 0.4686 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0202 | 0.0866 | 0.0866 |
Leishmania major | cathepsin L-like protease | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0452 | 0.2381 | 0.171 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.026 | 0.122 | 0.122 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0834 | 0.4686 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0834 | 0.4686 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0834 | 0.4686 | 0.4686 |
Brugia malayi | Cathepsin L-like precursor | 0.0834 | 0.4686 | 0.4686 |
Echinococcus multilocularis | cysteine protease | 0.0834 | 0.4686 | 0.4686 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1713 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0452 | 0.2381 | 0.2381 |
Toxoplasma gondii | cathepsin B | 0.0663 | 0.3652 | 0.7332 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0192 | 0.081 | 0.081 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.081 | 0.081 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0834 | 0.4686 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0834 | 0.4686 | 0.4218 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0192 | 0.081 | 0.081 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0192 | 0.081 | 0.081 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0192 | 0.081 | 0.081 |
Leishmania major | cathepsin L-like protease | 0.0834 | 0.4686 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1527 | 0.1527 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0574 | 0.3115 | 0.5946 |
Onchocerca volvulus | Cathepsin L homolog | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0834 | 0.4686 | 0.4686 |
Plasmodium vivax | vivapain-2 | 0.0834 | 0.4686 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0452 | 0.2381 | 0.2381 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0202 | 0.0866 | 0.0866 |
Plasmodium vivax | unspecified product | 0.0452 | 0.2381 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0574 | 0.3115 | 0.2508 |
Schistosoma mansoni | subfamily C1A non-peptidase homologue (C01 family) | 0.0192 | 0.081 | 0.081 |
Echinococcus granulosus | geminin | 0.017 | 0.0673 | 0.0673 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0192 | 0.081 | 0.081 |
Echinococcus multilocularis | geminin | 0.017 | 0.0673 | 0.0673 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0192 | 0.081 | 0.081 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0452 | 0.2381 | 0.2381 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0192 | 0.081 | 0.081 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0192 | 0.081 | 0.081 |
Brugia malayi | fibroinase precursor | 0.0192 | 0.081 | 0.081 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.026 | 0.122 | 0.122 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0192 | 0.081 | 0.081 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0834 | 0.4686 | 0.4218 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0452 | 0.2381 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.026 | 0.122 | 0.122 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.081 | 0.081 |
Entamoeba histolytica | cysteine protease, putative | 0.0452 | 0.2381 | 0.4054 |
Onchocerca volvulus | Cathepsin L homolog | 0.0192 | 0.081 | 0.0601 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0574 | 0.3115 | 0.3115 |
Onchocerca volvulus | Cathepsin F homolog | 0.0834 | 0.4686 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0834 | 0.4686 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0452 | 0.2381 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0574 | 0.3115 | 0.3115 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0192 | 0.081 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.1713 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0834 | 0.4686 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1713 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.122 | 0.122 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0834 | 0.4686 | 1 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0192 | 0.081 | 0.081 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 50 % | Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 release at 10 uM incubated for 2 hrs prior to LPS challenge measured after 22 hrs by ELISA relative to LPS-treated control | ChEMBL. | 23644212 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.