Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | brahma associated protein 60 kDa | 0.0982 | 1 | 1 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0982 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0349 | 0.3246 | 0.3246 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus multilocularis | Zinc finger, RanBP2 type | 0.0349 | 0.3246 | 0.3246 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0982 | 1 | 0.5 |
Toxoplasma gondii | Zn-finger in Ran binding protein and others domain-containing protein | 0.0349 | 0.3246 | 0.3246 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Schistosoma mansoni | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0982 | 1 | 1 |
Onchocerca volvulus | 0.0349 | 0.3246 | 0.3246 | |
Onchocerca volvulus | 0.0349 | 0.3246 | 0.3246 | |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0982 | 1 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0982 | 1 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0982 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0982 | 1 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0982 | 1 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0349 | 0.3246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0349 | 0.3246 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0982 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.00000024917 | 0.00000024917 |
Schistosoma mansoni | RNA binding protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0982 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0982 | 1 | 1 |
Echinococcus granulosus | Nuclear pore complex protein Nup153 | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0349 | 0.3246 | 1 |
Toxoplasma gondii | ran binding protein | 0.0349 | 0.3246 | 0.3246 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0982 | 1 | 1 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0349 | 0.3246 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0349 | 0.3246 | 0.3246 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0982 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0982 | 1 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0349 | 0.3246 | 1 |
Echinococcus granulosus | ring and YY1 binding protein | 0.0349 | 0.3246 | 0.3246 |
Schistosoma mansoni | hypothetical protein | 0.0982 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Brugia malayi | olfactory channel protein osm-9 | 0.0045 | 0.00000024917 | 0.00000024917 |
Loa Loa (eye worm) | brahma associated protein | 0.0982 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0349 | 0.3246 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0349 | 0.3246 | 0.3246 |
Chlamydia trachomatis | SWIB complex protein | 0.0982 | 1 | 0.5 |
Echinococcus granulosus | zinc finger protein Ran binding | 0.0349 | 0.3246 | 0.3246 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.00000024917 | 0.00000024917 |
Schistosoma mansoni | hypothetical protein | 0.0982 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Onchocerca volvulus | 0.0982 | 1 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0982 | 1 | 0.5 |
Schistosoma mansoni | fusion | 0.0349 | 0.3246 | 0.3246 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0982 | 1 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0982 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.00000024917 | 0.00000024917 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0349 | 0.3246 | 1 |
Echinococcus multilocularis | Nuclear pore complex protein Nup153 | 0.0349 | 0.3246 | 0.3246 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0349 | 0.3246 | 0.3246 |
Onchocerca volvulus | 0.0349 | 0.3246 | 0.3246 | |
Onchocerca volvulus | 0.0349 | 0.3246 | 0.3246 | |
Schistosoma mansoni | transient receptor potential channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0349 | 0.3246 | 0.3246 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0349 | 0.3246 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0982 | 1 | 1 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0349 | 0.3246 | 1 |
Echinococcus granulosus | Zinc finger RanBP2 type | 0.0349 | 0.3246 | 0.3246 |
Schistosoma mansoni | transient receptor potential channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0349 | 0.3246 | 1 |
Echinococcus multilocularis | ring and YY1 binding protein | 0.0349 | 0.3246 | 0.3246 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0045 | 0.00000024917 | 0.00000024917 |
Echinococcus multilocularis | zinc finger protein Ran binding | 0.0349 | 0.3246 | 0.3246 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 1.85 uM | Apomorphine-induced inhibition of potassium evoked release of [3H]- acetylcholine from striatal slices of rat | ChEMBL. | 8230103 |
KB (ADMET) | = 3.9 uM | Calculated antagonist equilibrium dissociation constant of the compound | ChEMBL. | 8230103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.