Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0145 | 0.0694 | 0.9336 |
Echinococcus multilocularis | carbohydrate kinase, thermoresistant glucokinase | 0.0151 | 0.0743 | 1 |
Echinococcus granulosus | thermoresistant glucokinase family carbohydrate | 0.0151 | 0.0743 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0145 | 0.0694 | 0.9336 |
Mycobacterium ulcerans | shikimate kinase | 0.1145 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0071 | 0 | 0.5 |
Mycobacterium tuberculosis | Shikimate kinase AroK (SK) | 0.1145 | 1 | 0.5 |
Onchocerca volvulus | 0.0071 | 0 | 0.5 | |
Schistosoma mansoni | shikimate-kinase | 0.0151 | 0.0743 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0145 | 0.0694 | 0.9336 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0694 | 1 |
Echinococcus granulosus | carbohydrate kinase thermoresistant glucokinase | 0.0151 | 0.0743 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0145 | 0.0694 | 0.9336 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0694 | 1 |
Mycobacterium leprae | Shikimate kinase AroK (SK) | 0.1145 | 1 | 0.5 |
Trypanosoma cruzi | carbohydrate kinase, thermoresistant glucokinase, putative | 0.0151 | 0.0743 | 0.5 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0151 | 0.0743 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0071 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0151 | 0.0743 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.424 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.415 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.