Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2912 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2912 | 1 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.2912 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2912 | 1 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.2912 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Functional [35S]-GTP-gammaS, binding for human ORL1 receptor carried out in CHO cell membranes. | ChEMBL. | 12372523 | |
Activity (functional) | 0 | Functional [35S]-GTP-gammaS, binding for human ORL1 receptor carried out in CHO cell membranes. | ChEMBL. | 12372523 |
Ki (binding) | = 37 nM | Binding affinity at human ORL1 receptor was determined by using [125I]-Nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a concentration of 23 pM | ChEMBL. | 12372523 |
Ki (binding) | = 37 nM | Binding affinity at human ORL1 receptor was determined by using [125I]-Nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a concentration of 23 pM | ChEMBL. | 12372523 |
Ki (binding) | = 1232 nM | Binding affinity at human opioid receptor kappa 1 was determined by using [3H]-diprenorphine radioligand in CHO cell membranes at a concentration of 0.31 nM | ChEMBL. | 12372523 |
Ki (binding) | = 1232 nM | Binding affinity at human opioid receptor kappa 1 was determined by using [3H]-diprenorphine radioligand in CHO cell membranes at a concentration of 0.31 nM | ChEMBL. | 12372523 |
Ki (binding) | = 1654 nM | Binding affinity at human opioid receptor mu 1 was determined by using [3H]-diprenorphine radioligand in CHO cell membranes at a concentration of 0.12 nM | ChEMBL. | 12372523 |
Ki (binding) | = 1654 nM | Binding affinity at human opioid receptor mu 1 was determined by using [3H]-diprenorphine radioligand in CHO cell membranes at a concentration of 0.12 nM | ChEMBL. | 12372523 |
Ki (binding) | = 8344 nM | Binding affinity at human opioid receptor delta 1 was determined by using [3H]-diprenorphine radioligand in CHO cell membranes at a concentration of 0.8 nM | ChEMBL. | 12372523 |
Ki (binding) | = 8344 nM | Binding affinity at human opioid receptor delta 1 was determined by using [3H]-diprenorphine radioligand in CHO cell membranes at a concentration of 0.8 nM | ChEMBL. | 12372523 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.